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TOCILIZUMAB (Actemra) is a recombinant humanized anti-human interleukin-6 (IL-6) receptor monoclonal antibody of the immunoglobulin IgG1κ subclass. Two heavy chain and two light chain polypeptides are linked by intra- and inter-molecular disulfide bonds. Endogenous IL-6 is induced by inflammatory stimuli and mediates a variety of immunological responses. Inhibition of IL-6 receptors by tocilizumab leads to a reduction in cytokine and acute phase reactant production.
Patient Medication Guide
Full Prescribing Information
Tocilizumab is indicated for:
Rheumatoid Arthritis (RA)
Polyarticular Juvenile Idiopathic Arthritis (PJIA)
Systemic Juvenile Arthritis
Most common adverse reactions (>5%): upper respiratory tract infections, nasopharyngitis, headache, hypertension, increased ALT and injection site reactions.
If the answer is yes to any of these questions, notify the ordering provider before initiating the infusion therapy.
Updated January 2017 - ARHP Practice Committee
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