Glossary

Looking for rheumatic disease types, treatments, and associated rheumatology definitions? From abatacept to WOMAC, learn about common terms related to arthritis and rheumatic and musculoskeletal diseases. Looking for information about MACRA? See MACRA terms and definitions.


T

Tumor necrosis factor (TNF)

Polypeptide cytokine, produced by endotoxin-activated macrophages, that has the ability to modulate adipocyte metabolism, lyse tumor cells in vitro, and induce hemorrhagic necrosis of certain transplantable tumors in vivo. Used worldwide to treat inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, inflammatory bowel disease (Crohn’s and ulcerative colitis), ankylosing spondylitis, and psoriasis.

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Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)

Condition characterized by recurrent episodes of fever. These fevers typically last about 3 weeks, but can last from a few days to a few months. Additional signs and symptoms include abdominal and muscle pain and a spreading skin rash, typically found on the limbs. Affected individuals may also experience puffiness or swelling in the skin around the eyes (periorbital edema), joint pain, and inflammation in various areas of the body, including the eyes, heart muscle, certain joints, throat, or mucous membranes, such as the moist lining of the mouth and digestive tract.

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