Anakinra is a biologic drug that helps to decrease inflammation in rheumatoid arthritis and other inflammatory diseases. A biologic drug is man-made through genetic-engineering techniques and closely mimics a protein that occurs naturally in the body.
Anakinra is FDA approved to treat rheumatoid arthritis, deficiency of interleukin-1 antagonist, and neonatal-onset multisystem inflammatory disease (NOMID). Although not an FDA-approved indication, anakinra is sometimes used to treat systemic juvenile idiopathic arthritis (SJIA), Adult-Onset Still’s Disease (AOSD), gout, and other auto-inflammatory syndromes.
For rheumatoid arthritis, the standard dose is 100mg per day injected under the skin. In children with neonatal-onset multisystem inflammatory disease (NOMID) and other auto inflammatory diseases, the dose is adjusted for patient weight. In children, the starting dose is 1-2mg/kg daily. The dose can be taken every other day in patients with decreased kidney function. Anakinra is effective by itself. In the case of rheumatoid arthritis, anakinra can be taken with methotrexate.
Anakinra must be stored in a refrigerator and warmed to room temperature before use. A nurse or physician can teach patients how to give themselves the injections. It often helps to bring a spouse or friend along to learn how to do the injections. Anakinra can be injected in the front of the thigh or abdomen. Injection sites should be rotated so that the same site is not used repeatedly.
Anakinra relieved symptoms in four – six weeks in the clinical trials for rheumatoid arthritis. In neonatal-onset multisystem inflammatory disease, systemic juvenile idiopathic arthritis, Adult-Onset Still’s Disease, gout, and other autoinflammatory disorders, anakinra may begin to relieve symptoms within hours.
The most common side effects are injection site reactions such as redness, itching, rash, and pain. Bruising or bleeding also can occur, but it is rare. These effects usually stop after one – two weeks. Headaches and low white blood cell counts also can occur, but these are very rare. Anakinra can increase the risk of infections. Periodic blood tests and monitoring for infection by a doctor is recommended. Patients taking anakinra should notify their doctors immediately if they develop fevers or other infection symptoms.
Anakinra has no known interactions with other medications. Anakinra should not be used at the same time as other biologics [e.g., etanercept (Enbrel), adalimumab (Humira), infliximab (Remicade), certolizumab (Cimzia), golimumab (Simponi), abatacept (Orencia), or tocilizumab (Actemra), or Rituximab (Rituxan and MabThera) This is because all biologics increase the risk for infection.
Anakinra can increase your risk of infection. See your rheumatology provider if you are not feeling well or if you develop a fever. Your rheumatology provider can stop anakinra and start antibiotics, if needed. Anakinra blocks one of the pathways that cause inflammation—this pathway is also used to fight infections. Patients taking anakinra should not receive live vaccines, such as certain forms of the influenza vaccine and yellow fever. Please consult your rheumatology provider beforehand.
Updated February 2022 by Ali Duarte Garcia, MD, and reviewed by the American College of Rheumatology Committee on Communications and Marketing.
This patient fact sheet is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of a medical or health condition.