2701

Editorial: Can We Accurately Predict the Development of Rheumatoid Arthritis in the Preclinical Phase? 

Darcy S. Majka and V. Michael Holers

2706 

Editorial: Guidelines for Monitoring of Methotrexate Therapy: ''Evidence-Based Medicine'' Outside of Clinical Trials 

Theodore Pincus

2710

Editorial: On the Track of Neuropsychiatric Lupus 

Betty Diamond and Bruce Volpe

2713

Review: The Multiple Facets of Premature Aging in Rheumatoid Arthritis

Rainer H. Straub, Jurgen Scholmerich, and Maurizio Cutolo

2722

Review: Extracellular Nucleotide Metabolism and Signaling in the Pathophysiology of Articular Cartilage

Maryse Picher, Ronald D. Graff, and Greta M. Lee

2737

Winners of the 2002 American College of Rheumatology Annual Slide Competition 

Marc L. Miller and the ACR Audiovisual Aids Subcommittee

2739

In Memoriam: Currier McEwen, MD, 1902-2003 

Martha Marston Block and Sidney R. Block

2741

Antibodies Against Cyclic Citrullinated Peptide and IgA Rheumatoid Factor Predict the Development of Rheumatoid Arthritis 

Solbritt Rantapaa-Dahlqvist, Ben A. W. de Jong, Ewa Berglin, Goran Hallmans, Goran Wadell, Hans Stenlund, Ulf Sundin, and Walther J. van Venrooij

2750

Direct Medical Costs and Their Predictors in Patients With Rheumatoid Arthritis: A Three-Year Study of 7,527 Patients 

Kaleb Michaud, Jodi Messer, Hyon K. Choi, and Frederick Wolfe

2763

Tacrolimus in Rheumatoid Arthritis Patients Receiving Concomitant Methotrexate: A Six-Month, Open-Label Study 

Joel M. Kremer, Joseph S. Habros, Karen S. Kolba, Jeffrey L. Kaine, Mary Ann Borton, Laurel J. Mengle-Gaw, Benjamin D. Schwartz, Wayne Wisemandle, and Qais A. Mekki, for the Tacrolimus-Methotrexate Rheumatoid Arthritis Study Group

2769 

Monitoring by Rheumatologists for Methotrexate-, Etanercept-, Infliximab-, and Anakinra-Associated Adverse Events 

Yusuf Yazici, Doruk Erkan, and Stephen A. Paget

2773

Polymorphisms in the Interferon-[gg]/Interleukin-26 Gene Region Contribute to Sex Bias in Susceptibility to Rheumatoid Arthritis 

K. Vandenbroeck, S. Cunningham, A. Goris, I. Alloza, S. Heggarty, C. Graham, A. Bell, and M. Rooney

2779

Differential Expression of HLA Class II Genes Associated With Disease Susceptibility and Progression in Rheumatoid Arthritis 

Christian Heldt, Joachim Listing, Osman Sozeri, Franca Blasing, Stefan Frischbutter, and Brigitte Muller

2788

Galectin 3 and Its Binding Protein in Rheumatoid Arthritis

Shiro Ohshima, Stefan Kuchen, Christian A. Seemayer, Diego Kyburz, Astrid Hirt, Stephanie Klinzing, Beat A. Michel, Renate E. Gay, Fu-Tong Liu, Steffen Gay, and Michel Neidhart

2796

Synovial Fluid Neutrophils Transcribe and Express Class II Major Histocompatibility Complex Molecules in Rheumatoid Arthritis 

Andrew Cross, Roger C. Bucknall, Marco A. Cassatella, Steven W. Edwards, and Robert J. Moots

2807

Bone Morphogenetic Proteins 2 and 6, Expressed in Arthritic Synovium, Are Regulated by Proinflammatory Cytokines and Differentially Modulate Fibroblast-Like Synoviocyte Apoptosis 

Rik J. U. Lories, Inge Derese, Jan L. Ceuppens, and Frank P. Luyten

2819

Prostaglandin E2 Is an Enhancer of Interleukin-1[gb]-Induced Expression of Membrane-Associated Prostaglandin E Synthase in Rheumatoid Synovial Fibroblasts 

Fumiaki Kojima, Hiroaki Naraba, Yasuharu Sasaki, Moroe Beppu, Haruhito Aoki, and Shinichi Kawai

2829

Feasibility of T and Z Scores From Magnetic Resonance Imaging Data for Quantification of Cartilage Loss in Osteoarthritis

R. Burgkart, C. Glaser, S. Hinterwimmer, M. Hudelmaier, K.-H. Englmeier, M. Reiser, and F. Eckstein

2836

Periarticular Lesions Detected on Magnetic Resonance Imaging: Prevalence in Knees With and Without Symptoms

Catherine L. Hill, Daniel R. Gale, Christine E. Chaisson, Katherine Skinner, Lewis Kazis, M. Elon Gale, and David T. Felson

2845

Tumor Necrosis Factor [ga] Activation of the Apoptotic Cascade in Murine Articular Chondrocytes Is Associated With the Induction of Metalloproteinases and Specific Pro-Resorptive Factors 

Tae-Joon Cho, Wolfgang Lehmann, Cory Edgar, Cameron Sadeghi, Andrew Hou, Thomas A. Einhorn, and Louis C. Gerstenfeld

2855

Endothelin 1 Promotes Osteoarthritic Cartilage Degradation Via Matrix Metalloprotease 1 and Matrix Metalloprotease 13 Induction 

Marjolaine Roy-Beaudry, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Khatija Nait M'Barek, Stephan Christgau, Fazool Shipkolye, and Florina Moldovan

2865

Hydrostatic Pressure Modulates Proteoglycan Metabolism in Chondrocytes Seeded in Agarose 

Takashi Toyoda, Bahaa B. Seedhom, Jian Q. Yao, Jennifer Kirkham, Steven Brookes, and William A. Bonass

2873

Accelerated, Aging-Dependent Development of Osteoarthritis in [ga]1 Integrin-Deficient Mice 

Michihisa Zemmyo, E. John Meharra, Klaus Kuhn, Lilo Creighton-Achermann, and Martin Lotz

2881

Neuronal and Astrocytic Damage in Systemic Lupus Erythematosus Patients With Central Nervous System Involvement 

Estelle Trysberg, Karin Nylen, Lars E. Rosengren, and Andrej Tarkowski

2888

Increased Apoptotic Neutrophils and Macrophages and Impaired Macrophage Phagocytic Clearance of Apoptotic Neutrophils in Systemic Lupus Erythematosus 

Yi Ren, Jinling Tang, M. Y. Mok, Albert W. K. Chan, Adrian Wu, and C. S. Lau

2898

Investigation of the Role of ANKH in Ankylosing Spondylitis 

A. E. Timms, Y. Zhang, L. Bradbury, B. P. Wordsworth, and M. A. Brown

2903

Experimental Immunity to the G1 Domain of the Proteoglycan Versican Induces Spondylitis and Sacroiliitis, of a Kind Seen in Human Spondylarthropathies

Shuiliang Shi, Cristina Ciurli, Annie Cartman, Isabelle Pidoux, A. Robin Poole, and Yiping Zhang

2916 

Subgrouping of Fibromyalgia Patients on the Basis of Pressure-Pain Thresholds and Psychological Factors 

Thorsten Giesecke, David A. Williams, Richard E. Harris, Thomas R. Cupps, Xiaoming Tian, Thomas X. Tian, Richard H. Gracely, and Daniel J. Clauw

2923 

Temperament and Stress Response in Children With Juvenile Primary Fibromyalgia Syndrome 

Paola M. Conte, Gary A. Walco, and Yukiko Kimura

2931

Inhibition of Monosodium Urate Monohydrate Crystal-Induced Acute Inflammation by Retrovirally Transfected Prostaglandin D Synthase 

Yousuke Murakami, Tohru Akahoshi, Izumi Hayashi, Hirahito Endo, Atsushi Hashimoto, Shizuka Kono, Hirobumi Kondo, Shinichi Kawai, Matsuhisa Inoue, and Hidero Kitasato

2942

Urinary Type II Collagen Neoepitope as an Outcome Measure for Relapsing Polychondritis 

Virginia B. Kraus, Thomas Stabler, Elizabeth T. Le, Mary Saltarelli, and Nancy B. Allen

2949

Effectiveness of the Soluble Form of the Interleukin-1 Receptor Accessory Protein as an Inhibitor of Interleukin-1 in Collagen-Induced Arthritis 

R. L. Smeets, F. A. J. van de Loo, L. A. B. Joosten, O. J. Arntz, M. B. Bennink, W. A. Loesberg, I. P. Dmitriev, D. T. Curiel, M. U. Martin, and W. B. van den Berg

2959

Induction of Arthritis in SCID Mice by T Cells Specific for the ``Shared Epitope'' Sequence in the G3 Domain of Human Cartilage Proteoglycan 

Anita Hanyecz, Tamas Bardos, Suzanne E. Berlo, Edit Buzas, Andrew B. Nesterovitch, Katalin Mikecz, and Tibor T. Glant

2974

Reduction of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice by Passive Administration of Antiphospholipid Antibody 

Danielle Nicolo, Bruce I. Goldman, and Marc Monestier

2979

The Energy Cost of Adjuvant-Induced Arthritis in Rats 

Tara Goodson, Sarah L. Morgan, Jodelle R. Carlee, and Joseph E. Baggott

2983

Dependence on Interferon-[gg] for the Spontaneous Occurrence of Arthritis in DBA/1 Mice 

Patrick Matthys, Rik J. Lories, Bert De Klerck, Hubertine Heremans, Frank P. Luyten, and Alfons Billiau

2989

Lack of Association Between Birth Order and Juvenile Idiopathic Arthritis 

Sampath Prahalad, Alison M. Fraser, Elizabeth O'Brien, Richard A. Kerber, Geraldine P. Mineau, and John F. Bohnsack

2990

Ecotropic Murine Leukemia Viruses and Exogenous Mouse Mammary Tumor Viruses Are Not Essential for Pristane-Induced Lupus

Jun Akaogi, Dina C. Nacionales, Yoshiki Kuroda, Westley H. Reeves, and Minoru Satoh

2992

Role of the H-2 Haplotype in Fas-Intact Lupus-Prone MRL Mice: Association With Autoantibodies but Not Renal Disease 

Philip L. Kong, Tongping Zhu, Michael P. Madaio, and Joseph Craft

2995

Terminology in Article by Aganna et al (Arthritis Rheum, September 2003)

2996

Early Changes in Bone Metabolism in Rheumatoid Arthritis Patients Treated With Infliximab 

M. Vis, GJ. Wolbink, M. C. Lodder, P. J. Kostense, R. J. van de Stadt, M. H. M. T. de Koning, B. A. C. Dijkmans, and W. F. Lems

2997

Correlation Between Clinical Response to Treatment and Radiographic Progression: Comment on the Article by Strand and Sharp 

Rolf Rau

2998

Reply 

Vibeke Strand and John Sharp

2999

Shrinking Lung Syndrome in Systemic Sclerosis

Carlo Alberto Scire, Roberto Caporali, Marinella Zanierato, Francesco Mojoli, Antonio Braschi, and Carlomaurizio Montecucco

3000

Pseudoleukocytosis in cryoglobulinemia 

Jefferson R. Roberts and David R. Finger

 Cover image: The figure on the cover (from Cross et al, page 2802) illustrates fluorescence imaging of class II major histocompatibility complex molecule expression on cultured synovial fluid neutrophils. The superimposed image depicts the class II MHC molecule in green and the nucleus in red. The presence of class II MHC molecules on neutrophils suggests a possible interaction with T cells, which could be relevant in the pathogenesis of rheumatoid arthritis.