3001 

Editorial: Means, Responders, and Meaning: Evaluation of Clinical Trials in Osteoarthritis 

Thomas J. Schnitzer

3004 

Editorial: New Approaches to Prevention of Thrombosis in the Antiphospholipid Syndrome: Hopes, Trials, and Tribulations 

Robert A. S. Roubey

3009 

Editorial: Systemic and Local Regulation of Articular Cartilage Metabolism: Where Does Leptin Fit in the Puzzle? 

Richard F. Loeser

3013 

Review: Infections and Anti-Tumor Necrosis Factor [ga] Therapy 

Todd Ellerin, Robert H. Rubin, and Michael E. Weinblatt

3023 

Review: Raynaud's Phenomenon and the Role of Capillaroscopy 

Maurizio Cutolo, Walter Grassi, and Marco Matucci Cerinic

3031 

Comparison of Rheumatoid Arthritis Clinical Trial Outcome Measures: A Simulation Study 

Jennifer J. Anderson, James A. Bolognese, and David T. Felson

3039 

Prognostic Factors in a Large Cohort of Patients With Early Undifferentiated Inflammatory Arthritis After Application of a Structured Management Protocol 

Mark A. Quinn, Michael J. Green, Helena Marzo-Ortega, Susanna Proudman, Zunaid Karim, Richard J. Wakefield, Philip G. Conaghan, and Paul Emery

3046 

Association Between Etanercept Use and Employment Outcomes Among Patients With Rheumatoid Arthritis 

Edward Yelin, Laura Trupin, Patricia Katz, Deborah Lubeck, Stephanie Rush, and Lee Wanke

3055 

Coffee Consumption and Risk of Rheumatoid Arthritis 

Elizabeth W. Karlson, Lisa A. Mandl, Gideon N. Aweh, and Francine Grodstein

3061 

Inflammation and Bone Resorption as Independent Factors of Accelerated Arterial Wall Thickening in Patients With Rheumatoid Arthritis 

Mayumi Nagata-Sakurai, Masaaki Inaba, Hitoshi Goto, Yasuro Kumeda, Yutaka Furumitsu, Kentaro Inui, Hidenori Koyama, Masanori Emoto, Eiji Ishimura, Tetsuo Shoji, and Yoshiki Nishizawa

3068 

Tumor Necrosis Factor [ga], Its Soluble Receptor I, and [minus]308 Gene Promoter Polymorphism in Patients With Rheumatoid Arthritis With or Without Amyloidosis: Implications for the Pathogenesis of Nephropathy and Anemia of Chronic Disease in Reactive Amyloidosis 

C. P. J. Maury, M. Liljestrom, K. Laiho, S. Tiitinen, K. Kaarela, and M. Hurme

3077 

Use of Positron Emission Tomography With Methyl-11C-Choline and 2-18F-Fluoro-2-Deoxy-d-Glucose in Comparison With Magnetic Resonance Imaging for the Assessment of Inflammatory Proliferation of Synovium 

Anne Roivainen, Riitta Parkkola, Timo Yli-Kerttula, Pertti Lehikoinen, Tapio Viljanen, Timo Mottonen, Pirjo Nuutila, and Heikki Minn

3085 

Turnover of Type II Collagen and Aggrecan in Cartilage Matrix at the Onset of Inflammatory Arthritis in Humans: Relationship to Mediators of Systemic and Local Inflammation 

Alexander Fraser, Ursula Fearon, R. Clark Billinghurst, Mirela Ionescu, Richard Reece, Thomas Barwick, Paul Emery, A. Robin Poole, and Douglas J. Veale

3096 

Rheumatoid Arthritis Synovial Fluid Macrophages Express Decreased Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand R2 and Increased Decoy Receptor Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand R3 

Harris Perlman, Nadine Nguyen, Hongtao Liu, Joy Eslick, Sybille Esser, Kenneth Walsh, Terry L. Moore, and Richard M. Pope

3102 

Comparing the Efficacy of Cyclooxygenase 2-Specific Inhibitors in Treating Osteoarthritis: Appropriate Trial Design Considerations and Results of a Randomized, Placebo-Controlled Trial 

Allan Gibofsky, Gary W. Williams, Frank McKenna, and John G. Fort

3112 

Risk Factors for Progression of Lumbar Spine Disc Degeneration: The Chingford Study 

G. Hassett, D. J. Hart, N. J. Manek, D. V. Doyle, and T. D. Spector

3118 

Evidence for a Key Role of Leptin in Osteoarthritis 

Helene Dumond, Nathalie Presle, Bernard Terlain, Didier Mainard, Damien Loeuille, Patrick Netter, and Pascale Pottie

3130 

The Release of Crosslinked Peptides From Type II Collagen Into Human Synovial Fluid Is Increased Soon After Joint Injury and in Osteoarthritis 

L. Stefan Lohmander, Lynne M. Atley, Terri A. Pietka, and David R. Eyre

3140 

Nitrite-Mediated Protection Against Hypochlorous Acid-Induced Chondrocyte Toxicity: A Novel Cytoprotective Role of Nitric Oxide in the Inflamed Joint? 

Matthew Whiteman, Peter Rose, Jia Ling Siau, and Barry Halliwell

3151 

Cyclic Tensile Stretch Loaded on Bovine Chondrocytes Causes Depolymerization of Hyaluronan: Involvement of Reactive Oxygen Species 

K. Yamazaki, K. Fukuda, M. Matsukawa, F. Hara, T. Matsushita, N. Yamamoto, K. Yoshida, H. Munakata, and C. Hamanishi

3159 

Risk Factors for Coronary Heart Disease in Women With Systemic Lupus Erythematosus: The Toronto Risk Factor Study 

Ian N. Bruce, Murray B. Urowitz, Dafna D. Gladman, Dominique Ibanez, and George Steiner

3168 

Coronary Artery Angiography in Systemic Lupus Erythematosus Patients With Abnormal Myocardial Perfusion Scintigraphy 

E. M. C. Sella, E. I. Sato, and A. Barbieri

3176 

Triplets With Systemic Lupus Erythematosus 

Sona S. Kamat, Peri H. Pepmueller, and Terry L. Moore

3181 

Extrasalivary Lymphoma Development in Sjogren's Syndrome: Clonal Evolution From Parotid Gland Lymphoproliferation and Role of Local Triggering 

Daniela Gasparotto, Salvatore De Vita, Valli De Re, Alessandra Marzotto, Ginevra De Marchi, Cathryn Ann Scott, Annunziata Gloghini, Gianfranco Ferraccioli, and Mauro Boiocchi

3187 

Cellular Basis of Ectopic Germinal Center Formation and Autoantibody Production in the Target Organ of Patients With Sjogren's Syndrome 

Stina Salomonsson, Malin V. Jonsson, Kathrine Skarstein, Karl A. Brokstad, Peter Hjelmstrom, Marie Wahren-Herlenius, and Roland Jonsson

3202 

The [minus]174G Allele of the Interleukin-6 Gene Confers Susceptibility to Systemic Arthritis in Children: A Multicenter Study Using Simplex and Multiplex Juvenile Idiopathic Arthritis Families 

Emma M. Ogilvie, Mark S. Fife, Susan D. Thompson, Natalie Twine, Monica Tsoras, Marta Moroldo, Sheila A. Fisher, Cathryn M. Lewis, Anne-Marie Prieur, David N. Glass, and Patricia Woo

3207 

Safety of Hydroxychloroquine in Pregnant Patients With Connective Tissue Diseases: A Study of One Hundred Thirty-Three Cases Compared With a Control Group 

Nathalie Costedoat-Chalumeau, Zahir Amoura, Pierre Duhaut, Du Le Thi Huong, Djamel Sebbough, Bertrand Wechsler, Daniele Vauthier, Isabelle Denjoy, Jean-Marc Lupoglazoff, and Jean-Charles Piette

3212 

Reduction of Job Loss in Persons With Rheumatic Diseases Receiving Vocational Rehabilitation: A Randomized Controlled Trial 

Saralynn H. Allaire, Wei Li, and Michael P. LaValley

3219 

Endothelial Nitric Oxide Synthase Gene Polymorphisms in Giant Cell Arteritis 

Carlo Salvarani, Bruno Casali, Davide Nicoli, Enrico Farnetti, Pierluigi Macchioni, Maria Grazia Catanoso, Qingquan Chen, GianLuigi Bajocchi, and Luigi Boiardi

3224 

Bone Density Threshold and Other Predictors of Vertebral Fracture in Patients Receiving Oral Glucocorticoid Therapy 

T. P. Van Staa, R. F. Laan, I. P. Barton, S. Cohen, D. M. Reid, and C. Cooper

3230 

Recombinant Human Tumor Necrosis Factor Receptor (Etanercept) for Treating Ankylosing Spondylitis: A Randomized, Controlled Trial 

John C. Davis, Jr., Desiree van der Heijde, Jurgen Braun, Maxime Dougados, John Cush, Daniel O. Clegg, Alan Kivitz, Roy Fleischmann, Robert Inman, and Wayne Tsuji, for the Enbrel Ankylosing Spondylitis Study Group

3237 

The Influence of Fetal Loss on the Presence of Fetal Cell Microchimerism: A Systematic Review 

Kiarash Khosrotehrani, Kirby L. Johnson, Joseph Lau, Alain Dupuy, Dong Hyun Cha, and Diana W. Bianchi

3242 

A Novel Polymorphism in the Fc[gg] Receptor IIB (CD32B) Transmembrane Region Alters Receptor Signaling 

Xiaoli Li, Jianming Wu, Robert H. Carter, Jeffrey C. Edberg, Kaihong Su, Glinda S. Cooper, and Robert P. Kimberly

3253 

Generation and Characterization of LymphoStat-B, a Human Monoclonal Antibody That Antagonizes the Bioactivities of B Lymphocyte Stimulator 

Kevin P. Baker, Bryan M. Edwards, Sarah H. Main, Gil H. Choi, Ruth E. Wager, Wendy G. Halpern, Patrick B. Lappin, Todd Riccobene, Donara Abramian, Les Sekut, Bonnie Sturm, Carol Poortman, Ralph R. Minter, Claire L. Dobson, Elizabeth Williams, Sara Carmen, Rodger Smith, Viktor Roschke, David M. Hilbert, Tristan J. Vaughan, and Vivian R. Albert

3266 

Articular, Monoclonal [gg]3 Heavy-Chain Deposition Disease: Characterization of a Partially Deleted Heavy-Chain Gene and Its Protein Product Synthesized In Vivo and In Vitro 

Keith M. Thompson, Knut Sletten, Per Brandtzaeg, Eva Kallberg, Tale Norbye Wien, and Gunnar Husby

3272 

Inhibition of the Thrombogenic and Inflammatory Properties of Antiphospholipid Antibodies by Fluvastatin in an In Vivo Animal Model 

Dardo E. Ferrara, Xiaowei Liu, Ricardo G. Espinola, Pier Luigi Meroni, Imad Abukhalaf, E. Nigel Harris, and Silvia S. Pierangeli

3280 

Acceleration of the Onset of Collagen-Induced Arthritis by a Deficiency of Platelet Endothelial Cell Adhesion Molecule 1 

Yoshifumi Tada, Syuichi Koarada, Fumitaka Morito, Osamu Ushiyama, Yoshio Haruta, Futoshi Kanegae, Akihide Ohta, Alexandra Ho, Tak W. Mak, and Kohei Nagasawa

3291 

Expression and Localization of Opioid Receptors in Muscle Satellite Cells: No Difference Between Fibromyalgia Patients and Healthy Subjects 

Souzan Salemi, Andre Aeschlimann, Renate E. Gay, Beat A. Michel, Steffen Gay, Lorenzo Kaeser, and Haiko Sprott

3293 

Humoral Immunity to Ro52 Is Not Associated With the Ro52 9571 C/T Polymorphism in Australian Patients With Primary Sjogren's Syndrome 

Sue Lester, Debashish Danda, Dana Cavill, Kevin Pile, Sarah Downie-Doyle, and Maureen Rischmueller

3295 

Examination of the Possible Role of Biologically Relevant Genes Around FBN1 in Systemic Sclerosis in the Choctaw Population 

Filemon K. Tan, Gina M. Tercero, Frank C. Arnett, Ning Wang, and Ranajit Chakraborty

3296 

Cytomegalovirus Infection and Antiphospholipid Syndrome in Humans 

J. Orts, J. Colomina, A. Zuniga, and A. Guerrero

3297 

The A/T Mutation in Exon 2 of the DNASE1 Gene Is Not Present in Tunisian Patients With Systemic Lupus Erythematosus or in Healthy Subjects 

Pampa Chakraborty, Hassen Hadj Kacem, Kauothar Makni-Karray, Faical Jarraya, Jamil Hachicha, and Hammadi Ayadi

3298 

Long-Term Followup Needed to Define Role of Infliximab in Treatment of Renal Amyloidosis: Comment on the Case Report by Elkayam et al 

Nurit Tweezer-Zaks, Pnina Langevitz, and Avi Livneh

3299 

Treatment of Renal Amyloidosis in Rheumatoid Arthritis Requires Further Investigation: Comment on the Case Report by Elkayam et al 

Gianfranco Ciboddo and Cristina Idone

3299

Ori Elkayam, Philip N. Hawkins, Helen Lachmann, and Dan Caspi

3300

Error in Table 3 of Article by Raynauld et al (Arthritis Rheum, February 2003)

12A

 Cover image: The figure on the cover (from Cutolo et al, page 3026) illustrates microvascular morphology as determined by capillaroscopy. This technique remains useful in defining vascular abnormalities in Raynaud's phenomenon and systemic sclerosis, for both diagnosis and investigation into pathogenesis.