1171

Editorial: Macrophage Migration Inhibitory Factor, MIF Alleles, and the Genetics of Inflammatory Disorders: Incorporating Disease Outcome Into the Definition of Phenotype 

Peter K. Gregersen and Richard Bucala

1177

Review: The Role of the Interleukin-6 Family of Cytokines in Inflammatory Arthritis and Bone Turnover 

Peter K. K. Wong, Ian K. Campbell, Paul J. Egan, Matthias Ernst, and Ian P. Wicks

1190

Review: Endothelin and Endothelin Receptor Antagonists in Systemic Rheumatic Disease 

Maureen D. Mayes

1200

Meta-Analysis of Four Rheumatoid Arthritis Genome-Wide Linkage Studies: Confirmation of a Susceptibility Locus on Chromosome 16 

S. A. Fisher, J. S. Lanchbury, and C. M. Lewis

1207

Dynamic Gadolinium-Enhanced Magnetic Resonance Imaging of the Wrist in Patients With Rheumatoid Arthritis Can Discriminate Active From Inactive Disease

Marco A. Cimmino, Stefania Innocenti, Fabrizio Livrone, Francesca Magnaguagno, Enzo Silvestri, and Giacomo Garlaschi

1214

Role of Metacarpophalangeal Joint Anatomic Factors in the Distribution of Synovitis and Bone Erosion in Early Rheumatoid Arthritis 

Ai Lyn Tan, Steven F. Tanner, Philip G. Conaghan, Aleksandra Radjenovic, Philip O'Connor, Andrew K. Brown, Paul Emery, and Dennis McGonagle

1223

Epstein-Barr Virus Load in the Peripheral Blood of Patients With Rheumatoid Arthritis: Accurate Quantification Using Real-Time Polymerase Chain Reaction 

Nathalie Balandraud, Jean Baptiste Meynard, Isabelle Auger, Helene Sovran, Benedicte Mugnier, Denis Reviron, Jean Roudier, and Chantal Roudier

1229

Selective Elimination of Synovial Inflammatory Macrophages in Rheumatoid Arthritis by an Fc[gg] Receptor I-Directed Immunotoxin 

Joel A. G. van Roon, Anneke J. van Vuuren, Siska Wijngaarden, Kim M. G. Jacobs, Johannes W. J. Bijlsma, Floris P. J. G. Lafeber, Theo Thepen, and Jan G. J. van de Winkel

1239

[gb]1 Integrin-Mediated Signaling Induces Intercellular Adhesion Molecule 1 and Fas on Rheumatoid Synovial Cells and Fas-Mediated Apoptosis 

Shingo Nakayamada, Kazuyoshi Saito, Koichi Fujii, Manabu Yasuda, Masahito Tamura, and Yoshiya Tanaka

1249

Responses to the Proinflammatory Cytokines Interleukin-1 and Tumor Necrosis Factor [ga] in Cells Derived From Rheumatoid Synovium and Other Joint Tissues Involve Nuclear Factor [gk]B-Mediated Induction of the Ets Transcription Factor ESE-1 

Franck Grall, Xuesong Gu, Lujian Tan, Je-Yoel Cho, Mehmet Sait Inan, Allison R. Pettit, Usanee Thamrongsak, Bob K. Choy, Cathy Manning, Yasmin Akbarali, Luiz Zerbini, Susan Rudders, Steven R. Goldring, Ellen M. Gravallese, Peter Oettgen, Mary B. Goldring, and Towia A. Libermann

1261

The Pathobiology of Focal Lesion Development in Aging Human Articular Cartilage and Molecular Matrix Changes Characteristic of Osteoarthritis 

Ginette R. Squires, Sharon Okouneff, Mirela Ionescu, and A. Robin Poole

1271

Involvement of CD44 in Induction of Matrix Metalloproteinases by a COOH-Terminal Heparin-Binding Fragment of Fibronectin in Human Articular Cartilage in Culture 

Tadashi Yasuda, A. Robin Poole, Makoto Shimizu, Takefumi Nakagawa, Sohel M. Julovi, Hirokazu Tamamura, Nobutaka Fujii, and Takashi Nakamura

1281

Insulin-Like Growth Factor 1-Induced Interleukin-1 Receptor II Overrides the Activity of Interleukin-1 and Controls the Homeostasis of the Extracellular Matrix of Cartilage 

Jun Wang, Dirk Elewaut, Eric M. Veys, and Gust Verbruggen

1292

Proteoglycan Degradation After Injurious Compression of Bovine and Human Articular Cartilage In Vitro: Interaction With Exogenous Cytokines  

Parth Patwari, Michael N. Cook, Michael A. DiMicco, Simon M. Blake, Ian E. James, Sanjay Kumar, Ada A. Cole, Michael W. Lark, and Alan J. Grodzinsky

1302

One of Two Chondrocyte-Expressed Isoforms of Cartilage Intermediate-Layer Protein Functions as an Insulin-Like Growth Factor 1 Antagonist 

Kristen Johnson, David Farley, Shou-Ih Hu, and Robert Terkeltaub

1315

Plasticity of Clonal Populations of Dedifferentiated Adult Human Articular Chondrocytes

Andrea Barbero, Sabine Ploegert, Michael Heberer, and Ivan Martin

1326

Inflammatory Cytokine Gene Expression in the Urinary Sediment of Patients With Lupus Nephritis 

Rebecca Wing-Yan Chan, Lai-Shan Tam, Edmund Kwok-Ming Li, Fernand Mac-Moune Lai, Kai-Ming Chow, Ka-Bik Lai, Philip Kam-Tao Li, and Cheuk-Chun Szeto

1332

Correlation Between Circulating CD27high Plasma Cells and Disease Activity in Patients With Systemic Lupus Erythematosus 

Annett M. Jacobi, Marcus Odendahl, Karin Reiter, Anne Bruns, Gerd R. Burmester, Andreas Radbruch, Gunter Valet, Peter E. Lipsky, and Thomas Dorner

1343

Increased Ubiquitination and Reduced Expression of LCK in T Lymphocytes From Patients With Systemic Lupus Erythematosus 

Elizabeth C. Jury, Panagiotis S. Kabouridis, Amina Abba, Rizgar A. Mageed, and David A. Isenberg

1355

Deposition of Nucleosomal Antigens (Histones and DNA) in the Epidermal Basement Membrane in Human Lupus Nephritis 

Cecile Grootscholten, Mieke C. J. van Bruggen, Johan W. van der Pijl, Elke M. G. J. de Jong, Gerry Ligtenberg, Ronald H. W. M. Derksen, and Jo H. M. Berden, for the Dutch Working Party on Systemic Lupus Erythematosus

1363

Correlation of Serum Anti-DNA Topoisomerase I Antibody Levels With Disease Severity and Activity in Systemic Sclerosis 

Paul Q. Hu, Noreen Fertig, Thomas A. Medsger, Jr., and Timothy M. Wright

1374

Anatomic Structures Involved in Early- and Late-Stage Sacroiliitis in Spondylarthritis: A Detailed Analysis by Contrast-Enhanced Magnetic Resonance Imaging

B. Muche, M. Bollow, R. J. Francois, J. Sieper, B. Hamm, and J. Braun

1385

Two Distinctive HLA Haplotypes Harbor the B27 Alleles Negatively or Positively Associated With Ankylosing Spondylitis in Sardinia: Implications for Disease Pathogenesis 

Maria Teresa Fiorillo, Alberto Cauli, Carlo Carcassi, Pier Paolo Bitti, Alessandra Vacca, Giuseppe Passiu, Francesca Bettosini, Alessandro Mathieu, and Rosa Sorrentino

1390

Daily Pain and Symptoms in Children With Polyarticular Arthritis 

Laura E. Schanberg, Kelly K. Anthony, Karen M. Gil, and Elana C. Maurin

1398

Functional and Prognostic Relevance of the [minus]173 Polymorphism of the Macrophage Migration Inhibitory Factor Gene in Systemic-Onset Juvenile Idiopathic Arthritis 

Fabrizio De Benedetti, Cristina Meazza, Marina Vivarelli, Federica Rossi, Angela Pistorio, Rebecca Lamb, Mark Lunt, Wendy Thomson, the British Paediatric Rheumatology Study Group, Angelo Ravelli, Rachelle Donn, and Alberto Martini

1408

Cytokine Gene Polymorphisms: Association With Psoriatic Arthritis Susceptibility and Severity 

Joanna Balding, David Kane, Wendy Livingstone, Lesley Mynett-Johnson, Barry Bresnihan, Owen Smith, and Oliver FitzGerald

1414

Intravertebral Clefts in Osteoporotic Vertebral Compression Fractures 

Fergus McKiernan and Tom Faciszewski

1420

Neurophysiologic Evidence for a Central Sensitization in Patients With Fibromyalgia

J. A. Desmeules, C. Cedraschi, E. Rapiti, E. Baumgartner, A. Finckh, P. Cohen, P. Dayer, and T. L. Vischer

1430

Amyloid-Enhancing Factor Mediates Amyloid Formation on Fibroblasts via a Nidus/Template Mechanism 

Nadine Magy, Juris J. Liepnieks, Merrill D. Benson, and Barbara Kluve-Beckerman

1438

Nonsteroidal Antiinflammatory Drugs and a Selective Cyclooxygenase 2 Inhibitor Uncouple Mitochondria in Intact Cells 

Manja M. Krause, Martin D. Brand, Stefan Krauss, Christian Meisel, Hartmut Vergin, Gerd-Rudiger Burmester, and Frank Buttgereit

1445

Genetic Basis of Tissue Specificity of Vasculitis in MRL/lpr Mice

Akihiro Yamada, Tatsuhiko Miyazaki, Ling-Min Lu, Masao Ono, Mitsuko R. Ito, Miho Terada, Shiro Mori, Kazuya Hata, Yoshimi Nozaki, Shuichi Nakatsuru, Yusuke Nakamura, Morikazu Onji, and Masato Nose

1452

CD25+ Cell Depletion Hastens the Onset of Severe Disease in Collagen-Induced Arthritis 

Mary E. Morgan, Roger P. M. Sutmuller, Hendrik J. Witteveen, Leonie M. van Duivenvoorde, Eric Zanelli, Cornelis J. M. Melief, Alies Snijders, Rienk Offringa, Rene R. P. de Vries, and Rene E. M. Toes

1461

Genetic Linkage of Primary Hip Osteoarthritis With Restricted Areas on Chromosome 11q: Comment on the Article by Chapman et al 

Paul Dieppe

1461

Reply

John Loughlin, Kay Chapman, and Andrew Carr

1462

Increased Mortality in Early Inflammatory Polyarthritis: Comment on the Article by Goodson et al 

Cathrin N. Slettjord and Hans C. Nossent

1462

Reply

N. J. Goodson, A. J. Silman, and D. P. M. Symmons

1463

High-Dose Cyclophosphamide Therapy Without Stem Cell Rescue for Severe Refractory Autoimmune Illnesses: Comment on the Article by Moore et al 

Ann A. Prestrud, Susan Hoch, Isadore Brodsky, and Douglas E. Gladstone

1463

CD34-Selected Versus Unmanipulated Grafts for Severe Rheumatoid Arthritis: Comment on the Article by Moore et al 

Jacob M. van Laar and Steven Z. Pavletic

1464

Reply

John Moore, Sam Milliken, David Ma, Jim Biggs, Peter Brooks, and John Snowden

1466

Efficacy of Low-Dose Versus High-Dose Cyclophosphamide in Lupus Nephritis: Comment on the Article by Houssiau et al 

Joel A. Block

1466

Reply

Frederic A. Houssiau, Carlos Vasconcelos, David D'Cruz, and Ricard Cervera, for the Euro-Lupus Nephritis Trial Group

1467

Persistent Efficacy of Tumor Necrosis Factor [ga] Blockage Therapy in SAPHO Syndrome: Comment on the Article by Wagner et al 

Ignazio Olivieri, Angela Padula, Giovanni Cianc|fio, Carlo Salvarani, Laura Niccoli, and Fabrizio Cantini

1467

Reply

A. D. Wagner, J. Andresen, M. C. Jendro, J. L. Hulsemann, and H. Zeidler

1468

Thrombotic Thrombocytopenic Purpura in a Patient With Behcet's Disease 

Fadi I. Jabr, Ali Shamseddine, Imad Uthman, Aref Chehal, and Ali Taher

1469

Reply

Hermine I. Brunner and Earl D. Silverman

1469

Some Anti-Proinflammatory Musings: Proinflammatory Is Inflammatory 

James T. Rosenbaum

Cover image: The figure on the cover (from Tan et al, page 1216) is a color representation of a magnetic resonance image of the metacarpophalangeal joints of a patient with rheumatoid arthritis. This technique allows assessment of the volume of synovitis and the location of erosions. The information can be used to delineate anatomic and biomechanical factors underlying the pathogenesis of joint damage in rheumatoid arthritis.