869

ACR Presidential Address: If I Am Not for Myself, Who Will Be for Me? 

Allan Gibofsky

873

Editorial: New Policy on Disclosure of Interest for American College of Rheumatology Journals 

David S. Pisetsky, Gene G. Hunder, and Ellen M. Gravallese

876

Editorial: High Mobility Group Box Chromosomal Protein 1 as a Nuclear Protein, Cytokine, and Potential Therapeutic Target in Arthritis 

Luis Ulloa, Franak M. Batliwalla, Ulf Andersson, Peter K. Gregersen, and Kevin J. Tracey

882

Editorial: A Role for BLyS in Tissue Inflammation? 

Robert H. Carter

886

Review: Specificities, Properties, and Clinical Significance of Antiprothrombin Antibodies 

Olga Amengual, Tatsuya Atsumi, and Takao Koike

896

Conference Summary: Report on the Second International Enthesitis Workshop 

Dennis McGonagle, Helena Marzo-Ortega, Michael Benjamin, and Paul Emery

906

Screening the Genome for Rheumatoid Arthritis Susceptibility Genes: A Replication Study and Combined Analysis of 512 Multicase Families 

Damini Jawaheer, Michael F. Seldin, Christopher I. Amos, Wei V. Chen, Russell Shigeta, Carol Etzel, Aarti Damle, Xiangli Xiao, Dong Chen, Raymond F. Lum, Joanita Monteiro, Marlene Kern, Lindsey A. Criswell, Salvatore Albani, J. Lee Nelson, Daniel O. Clegg, Richard Pope, Harry W. Schroeder, Jr., S. Louis Bridges, Jr., David S. Pisetsky, Ryk Ward, Daniel L. Kastner, Ronald L. Wilder, Theodore Pincus, Leigh F. Callahan, Donald Flemming, Mark H. Wener, and Peter K. Gregersen, for the North American Rheumatoid Arthritis Consortium

917

Prevalence of Rheumatoid Arthritis in Persons 60 Years of Age and Older in the United States: Effect of Different Methods of Case Classification 

Elizabeth K. Rasch, Rosemarie Hirsch, Ryne Paulose-Ram, and Marc C. Hochberg

927

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist (r-metHuIL-1ra), in Patients With Rheumatoid Arthritis: A Large, International, Multicenter, Placebo-Controlled Trial 

Roy M. Fleischmann, Joy Schechtman, Ralph Bennett, Malcolm L. Handel, Gerd-Rudiger Burmester, John Tesser, Dennis Modafferi, Jennifer Poulakos, and Gordon Sun, for the 990757 Study Group

935

Development of an Instrument to Measure Disability in Parenting Activity Among Women With Rheumatoid Arthritis 

Patricia P. Katz, Lauri A. Pasch, and Belinda Wong

944

Low Prevalence of Antibodies to Glucose-6-Phosphate Isomerase in Patients With Rheumatoid Arthritis and a Spectrum of Other Chronic Autoimmune Disorders 

Isao Matsumoto, David M. Lee, Raphaela Goldbach-Mansky, Takayuki Sumida, Carol A. Hitchon, Peter H. Schur, Ronald J. Anderson, Jonathan S. Coblyn, Michael E. Weinblatt, Michael Brenner, Bernard Duclos, Jean-Louis Pasquali, Hani El-Gabalawy, Diane Mathis, and Christophe Benoist

955

Interobserver Agreement in Ultrasonography of the Finger and Toe Joints in Rheumatoid Arthritis 

Marcin Szkudlarek, Michel Court-Payen, S\oren Jacobsen, Mette Klarlund, Henrik S. Thomsen, and Mikkel \Ostergaard

963

Risk of Malignant Lymphomas in Patients With Rheumatoid Arthritis and in Their First-Degree Relatives 

Karin Ekstrom, Henrik Hjalgrim, Lena Brandt, Eva Baecklund, Lars Klareskog, Anders Ekbom, and Johan Askling

971

High Mobility Group Box Chromosomal Protein 1 Plays a Role in the Pathogenesis of Rheumatoid Arthritis as a Novel Cytokine 

Noboru Taniguchi, Ko-ichi Kawahara, Kazunori Yone, Teruto Hashiguchi, Munekazu Yamakuchi, Masamichi Goto, Keiichi Inoue, Shingo Yamada, Kosei Ijiri, Shunji Matsunaga, Toshihiro Nakajima, Setsuro Komiya, and Ikuro Maruyama

982

Local Production of B Lymphocyte Stimulator Protein and APRIL in Arthritic Joints of Patients With Inflammatory Arthritis 

Soon-Min Tan, Dong Xu, Viktor Roschke, James W. Perry, Daniel G. Arkfeld, Glenn R. Ehresmann, Thi-Sau Migone, David M. Hilbert, and William Stohl

993

T Cells Regulate the Expression of Matrix Metalloproteinase in Human Osteoblasts via a Dual Mitogen-Activated Protein Kinase Mechanism  

Leonard Rifas and Sophia Arackal

1002

Increased Expression of Fc[gg] Receptors II and III on Macrophages of Rheumatoid Arthritis Patients Results in Higher Production of Tumor Necrosis Factor [ga] and Matrix Metalloproteinase 

Arjen B. Blom, Timothy R. D. J. Radstake, Astrid E. M. Holthuysen, Annet W. Sloetjes, Gerard J. Pesman, Fred G. J. Sweep, Fons A. J. van de Loo, L. A. B. Joosten, Pilar Barrera, Peter L. E. M. van Lent, and Wim B. van den Berg

1015

Antinuclear Antibodies Following Infliximab Treatment in Patients With Rheumatoid Arthritis or Spondylarthropathy 

Leen De Rycke, Elli Kruithof, Nancy Van Damme, Ilse E. A. Hoffman, Nancy Van den Bossche, Filip Van den Bosch, Eric M. Veys, and Filip De Keyser

1024

The Association of Body Mass Index and Osteoarthritis of the Knee Joint: An Examination of Genetic and Environmental Influences 

Nisha J. Manek, Deborah Hart, Timothy D. Spector, and Alexander J. MacGregor

1030

Weight From Birth to 53 Years: A Longitudinal Study of the Influence on Clinical Hand Osteoarthritis 

A. Aihie Sayer, J. Poole, V. Cox, D. Kuh, R. Hardy, M. Wadsworth, and C. Cooper

1034

Lower Prevalence of Hand Osteoarthritis Among Chinese Subjects in Beijing Compared With White Subjects in the United States: The Beijing Osteoarthritis Study 

Yuqing Zhang, Ling Xu, Michael C. Nevitt, Jingbo Niu, Joyce P. Goggins, Piran Aliabadi, Wei Yu, Li-Yung Lui, and David T. Felson

1041

Age and Sex Differences in Hip Joint Space Among Asymptomatic Subjects Without Structural Change: Implications for Epidemiologic Studies 

Peter Lanyon, Kenneth Muir, Sally Doherty, and Michael Doherty

1047

Matrix Fixed-Charge Density as Determined by Magnetic Resonance Microscopy of Bioreactor-Derived Hyaline Cartilage Correlates With Biochemical and Biomechanical Properties 

Chih-Tung Chen, Kenneth W. Fishbein, Peter A. Torzilli, Amy Hilger, Richard G. S. Spencer, and Walter E. Horton, Jr.

1057

Inhibition of Furin-Like Enzymes Blocks Interleukin-1[ga]/Oncostatin M-Stimulated Cartilage Degradation 

J. M. Milner, A. D. Rowan, S.-F. Elliott, and T. E. Cawston

1067

Treatment of Systemic Lupus Erythematosus-Associated Type B Insulin Resistance Syndrome With Cyclophosphamide and Mycophenolate Mofetil 

Anil Gehi, Allison Webb, Martha Nolte, and John Davis, Jr.

1071

Pathogenic T Cells in Murine Lupus Exhibit Spontaneous Signaling Activity Through Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways

Florin Niculescu, Phuong Nguyen, Teodora Niculescu, Horea Rus, Violeta Rus, and Charles S. Via

1080

Enhanced Susceptibility to End-Organ Disease in the Lupus-Facilitating NZW Mouse Strain 

Chun Xie, Xin J. Zhou, Xuebin Liu, and Chandra Mohan

1093

Efficacy of Etanercept for the Treatment of Juvenile Idiopathic Arthritis According to the Onset Type 

Pierre Quartier, Pierre Taupin, Franck Bourdeaut, Irene Lemelle, Pascal Pillet, Michel Bost, Jean Sibilia, Isabelle Kone-Paut, Sylvie Gandon-Laloum, Marc LeBideau, Brigitte Bader-Meunier, Richard Mouy, Marianne Debre, Paul Landais, and Anne-Marie Prieur

1102

Changes in Bone Mineral Density Following Discontinuation or Continuation of Alendronate Therapy in Glucocorticoid-Treated Patients: A Retrospective, Observational Study 

Ronald Emkey, Pierre D. Delmas, Stefan Goemaere, Uri A. Liberman, Patrice E. Poubelle, Anastasia G. Daifotis, Nadia Verbruggen, Antonio Lombardi, and Michelle Czachur

1109

Cellular Microchimerism as a Lifelong Physiologic Status in Parous Women: An Immunologic Basis for its Amplification in Patients With Systemic Sclerosis

Samuele E. Burastero, Silvia Galbiati, Antonia Vassallo, Maria Grazia Sabbadini, Matteo Bellone, Lucia Marchionni, Maddalena Smid, Elisabetta Ferrero, Augusto Ferrari, Maurizio Ferrari, and Laura Cremonesi

1117

Disruption of Tumor Necrosis Factor Receptor p55 Impairs Collagen Turnover in Experimentally Induced Sclerodermic Skin Fibroblasts 

Hiroyuki Murota, Youichiro Hamasaki, Tomoki Nakashima, Kazuo Yamamoto, Ichiro Katayama, and Toshifumi Matsuyama

1126

Magnetic Resonance Imaging Examinations of the Spine in Patients With Ankylosing Spondylitis, Before and After Successful Therapy With Infliximab: Evaluation of a New Scoring System 

J. Braun, X. Baraliakos, W. Golder, J. Brandt, M. Rudwaleit, J. Listing, M. Bollow, J. Sieper, and D. van der Heijde

1137

Crystal-Induced Neutrophil Activation. VIII. Immediate Production of Prostaglandin E2 Mediated by Constitutive Cyclooxygenase 2 in Human Neutrophils Stimulated by Urate Crystals 

Caroline Gilbert, Patrice E. Poubelle, Pierre Borgeat, Marc Pouliot, and Paul H. Naccache

1149

The Contribution of Genotypes at the MEFV and SAA1 Loci to Amyloidosis and Disease Severity in Patients With Familial Mediterranean Fever 

Ruth Gershoni-Baruch, Riva Brik, Nurit Zacks, Maruan Shinawi, Merav Lidar, and Avi Livneh

1156

Erysipelothrix rhusiopathiae Septic Arthritis 

Maria E. Ruiz, J. Steuart Richards, Gail S. Kerr, and Virginia L. Kan

1158

Disparate Results in Studies of Methotrexate Plus Corticosteroids in the Treatment of Giant Cell Arteritis: Comment on the Article by Hoffman et al 

Juan Angel Jover, Cesar Hernandez-Garcia, Inmaculada C. Morado, Emilio Vargas, Antonio Banares, and Benjamin Fernandez-Gutierrez

1159

Vision Loss in Giant Cell Arteritis Patients Treated With Alternate-Day Corticosteroids: Comment on the Article by Hoffman et al 

Robert F. Spiera, Mark Kupersmith, Stephen Paget, and Harry Spiera

1160

Reply

Gary S. Hoffman and John H. Stone

1161

Does Concomitant Osteoarthritis Affect Histopathologic Changes in Patients With Rheumatoid Arthritis? Comment on the Article by Kraan et al 

Nathan Wei

1162

Reply

Maarten C. Kraan, Richard J. Reece, Tom J. M. Smeets, Douglas J. Veale, Paul Emery, and Paul P. Tak

1162

Possible Role of Shared Epitope Status in the Relationship Between Matrix Metalloproteinase 3 Genotype and Radiographic Progression of Rheumatoid Arthritis: Comment on the Article by Constantin et al 

Niek de Vries and Paul P. Tak

1163

Reply

Alain Cantagrel, Valerie Lauwers-Cances, and Arnaud Constantin

1164

Anti-Glomerular Basement Membrane Antibody-Associated Renal Failure in a Patient With Leflunomide-Treated Rheumatoid Arthritis 

G. A. W. Bruyn, R. P. Veenstra, C. Halma, and J. Grond

1165

Etanercept-Induced Lupus-Like Syndrome in a Patient With Rheumatoid Arthritis 

Elise Carlson and Naomi Rothfield

1166

Reply

David S. Pisetsky

1166

Chondrocyte Apoptosis in Osteoarthritis: Comment on the Letter by Kouri and Abbud-Lozoya

Thomas Aigner

1167

Aquaporins in Primary Sjogren's Syndrome: Comment on the Articles by Steinfeld et al 

Sally A. Waterman, Dimitra Beroukas, Jenny Hiscock, Roland Jonsson, and Tom P. Gordon

1168

Use of an Artificial Neural Network to Predict Cancer Development in Patients With Inflammatory Myopathy: Comment on the Letter by Selva O'Callaghan et al 

Roland Linder, Eva Reinhold-Keller, and Wolfgang L. Gross

1169

Reply

Albert Selva-O'Callaghan, Enrique Romero-Merino, Jose M. Sopena-Sisquella, Tilman Mijares-Boeckh-Behrens, Roser Solans-Laque, Moises Labrador-Horrillo, and Miquel Vilardell-Tarres

1170

Neuropathic Joint in a Patient With Calcium Pyrophosphate Deposition Disease 

Paola Caramaschi, Domenico Biasi, Giuliano Villa, Antonio Carletto, and Lisa Maria Bambara

25A

Cover image: The figure on the cover (from Xie et al, page 1085) shows periodic acid-Schiff staining of a kidney section from a mouse injected with a rabbit anti-glomerular nephrotoxic serum. This model allows assessment of intrinsic susceptibility to kidney disease, enabling further delineation of genes contributing to glomerulonephritis in murine models of systemic lupus erythematosus.