3115

Editorial: Missed Opportunities in Physician Management of Glucocorticoid-Induced Osteoporosis?

Rosalind Ramsey-Goldman

3121

Review: Osteoprotegerin, an Endogenous Antiosteoclast Factor for Protecting Bone in Rheumatoid Arthritis

Brad Bolon, Victoria Shalhoub, Paul J. Kostenuik, Giuseppe Campagnuolo, Sean Morony, William J. Boyle, Debra Zack, and Ulrich Feige

3136

Management of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatoid Arthritis: Rates and Predictors of Care in an Academic Rheumatology Practice

Daniel H. Solomon, Jeffrey N. Katz, Jonathan P. Jacobs, Alison M. La Tourette, and Jonathan Coblyn

3143

Therapeutic Benefit of Blocking Interleukin-6 Activity With an Anti-Interleukin-6 Receptor Monoclonal Antibody in Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial

E. H. S. Choy, D. A. Isenberg, T. Garrood, S. Farrow, Y. Ioannou, H. Bird, N. Cheung, B. Williams, B. Hazleman, R. Price, K. Yoshizaki, N. Nishimoto, T. Kishimoto, and G. S. Panayi

3151

Tumor Necrosis Factor Antagonist Therapy and Lymphoma Development: Twenty-Six Cases Reported to the Food and Drug Administration

S. Lori Brown, Mark H. Greene, Sharon K. Gershon, Evelyne T. Edwards, and M. Miles Braun

3159

Induction of Apoptosis in Rheumatoid Synovial Fibroblasts by Celecoxib, but Not by Other Selective Cyclooxygenase 2 Inhibitors

Natsuko Kusunoki, Ryuta Yamazaki, and Shinichi Kawai

3168

The Geometric Architecture of the Subtalar and Midtarsal Joints in Rheumatoid Arthritis Based on Magnetic Resonance Imaging

James Woodburn, Jayaram K. Udupa, Bruce E. Hirsch, Richard J. Wakefield, Philip S. Helliwell, Naomi Reay, Philip O'Connor, Adam Budgen, and Paul Emery

3178

Evidence for Increased Bone Resorption in Patients With Progressive Knee Osteoarthritis: Longitudinal Results From the Chingford Study

Paolo Bettica, Gary Cline, Deborah J. Hart, Joan Meyer, and Tim D. Spector

3185

Nonrandom Evolution of End-Stage Osteoarthritis of the Lower Limbs

Najia Shakoor, Joel A. Block, Susan Shott, and John P. Case

3190

Functional Replacement of Oxygen by Other Oxidants in Articular Cartilage

Robert B. Lee and Jill P. G. Urban

3201

Growth-Related Oncogene [alpha] Induction of Apoptosis in Osteoarthritis Chondrocytes

Rosa Maria Borzi, Ilaria Mazzetti, Giorgia Magagnoli, Samantha Paoletti, Mariagrazia Uguccioni, Rita Gatti, Guido Orlandini, Luca Cattini, and Andrea Facchini

3212

Induction of Advanced Glycation End Products and Alterations of the Tensile Properties of Articular Cartilage

Albert C. Chen, Michele M. Temple, Darren M. Ng, Nicole Verzijl, Jeroen DeGroot, Johan M. TeKoppele, and Robert L. Sah

3218

Up-Regulated Expression of Cartilage Intermediate-Layer Protein and ANK in Articular Hyaline Cartilage From Patients With Calcium Pyrophosphate Dihydrate Crystal Deposition Disease

Jun Hirose, Lawrence M. Ryan, and Ikuko Masuda

3230

Bcl-3 Is an Interleukin-1-Responsive Gene in Chondrocytes and Synovial Fibroblasts That Activates Transcription of the Matrix Metalloproteinase 1 Gene

Sarah F. Elliott, Charles I. Coon, Ezra Hays, Terrance A. Stadheim, and Matthew P. Vincenti

3240

Expression of Matrix Metalloproteinases in Articular Cartilage of Temporomandibular and Knee Joints of Mice During Growth, Maturation, and Aging

Amira Gepstein, Sarah Shapiro, Gil Arbel, Nitza Lahat, and Erella Livne

3251

Treatment of Systemic Lupus Erythematosus by Inhibition of T Cell Costimulation With Anti-CD154: A Randomized, Double-Blind, Placebo-Controlled Trial

Kenneth C. Kalunian, John C. Davis, Jr., Joan T. Merrill, Mark C. Totoritis, and David Wofsy, for the IDEC-131 Lupus Study Group

3259

RP105-Lacking B Cells From Lupus Patients Are Responsible for the Production of Immunoglobulins and Autoantibodies

Yuji Kikuchi, Syuichi Koarada, Yoshifumi Tada, Osamu Ushiyama, Fumitaka Morito, Noriaki Suzuki, Akihide Ohta, Kensuke Miyake, Masao Kimoto, Takahiko Horiuchi, and Kohei Nagasawa

3266

Identity of the RNase MRP- and RNase P-Associated Th/To Autoantigen

Hans van Eenennaam, Judith H. P. Vogelzangs, Dorien Lugtenberg, Frank H. J. van den Hoogen, Walther J. van Venrooij, and Ger J. M. Pruijn

3273

A New Conformational Epitope Generated by the Binding of Recombinant 70-kd Protein and U1 RNA to Anti-U1 RNP Autoantibodies in Sera From Patients With Mixed Connective Tissue Disease

Akihiro Murakami, Kazuo Kojima, Kazuhiko Ohya, Koji Imamura, and Yoshinari Takasaki

3283

Effects of [beta]2-Glycoprotein I and Monoclonal Anticardiolipin Antibodies in Platelet Interaction With Subendothelium Under Flow Conditions

Josep Font, Gerard Espinosa, Dolors Tassies, Marc Pino, Munther A. Khamashta, Teresa Gallart, Ricard Cervera, Gines Escolar, Graham R. V. Hughes, Miguel Ingelmo, Antoni Ordinas, and Joan-Carles Reverter

3290

Induction of Cell Death by Sera From Patients With Acute Brain Injury as a Mechanism of Production of Autoantibodies

Herminio Lopez-Escribano, Eduardo Minambres, Moises Labrador, Maria Jose Bartolome, and Marcos Lopez-Hoyos

3301

Infliximab in Primary Sjogren's Syndrome: One-Year Followup

Serge D. Steinfeld, Paul Demols, and Thierry Appelboom

3304

Linkage and Association Studies of Single-Nucleotide Polymorphism-Tagged Tumor Necrosis Factor Haplotypes in Juvenile Oligoarthritis

Eleftheria Zeggini, Wendy Thomson, Dominic Kwiatkowski, Anna Richardson, William Ollier, Rachelle Donn, and The British Paediatric Rheumatology Study Group

3312

Cigarette Smoking as a Significant Risk Factor for Digital Vascular Disease in Patients With Systemic Sclerosis

Beverley J. Harrison, Alan J. Silman, Samantha L. Hider, and Ariane L. Herrick

3317

Interferon-[alpha] and Ribavirin Treatment in Patients With Hepatitis C Virus-Related Systemic Vasculitis

Patrice Cacoub, Olivier Lidove, Thierry Maisonobe, Pierre Duhaut, Vincent Thibault, Pascale Ghillani, Robert P. Myers, Jean Marc Leger, Jerome Servan, and Jean-Charles Piette

3327

Timing of Total Joint Replacement Affects Clinical Outcomes Among Patients With Osteoarthritis of the Hip or Knee

Paul R. Fortin, John R. Penrod, Ann E. Clarke, Yvan St-Pierre, Lawrence Joseph, Patrick Belisle, Matthew H. Liang, Diane Ferland, Charlotte B. Phillips, Nizar Mahomed, Michael Tanzer, Clement Sledge, Anne H. Fossel, and Jeffrey N. Katz

3331

The Effect of Education and Income on Need and Willingness to Undergo Total Joint Arthroplasty

Gillian A. Hawker, James G. Wright, Richard H. Glazier, Peter C. Coyte, Bart Harvey, J. Ivan Williams, and Elizabeth M. Badley

3340

De Novo CIAS1 Mutations, Cytokine Activation, and Evidence for Genetic Heterogeneity in Patients With Neonatal-Onset Multisystem Inflammatory Disease (NOMID): A New Member of the Expanding Family of Pyrin-Associated Autoinflammatory Diseases

Ivona Aksentijevich, Miroslawa Nowak, Mustapha Mallah, Jae Jin Chae, Wendy T. Watford, Sigrun R. Hofmann, Leonard Stein, Ricardo Russo, Donald Goldsmith, Peter Dent, Helene F. Rosenberg, Frances Austin, Elaine F. Remmers, James E. Balow, Jr., Sergio Rosenzweig, Hirsh Komarow, Nitza G. Shoham, Geryl Wood, Janet Jones, Nadira Mangra, Hector Carrero, Barbara S. Adams, Terry L. Moore, Kenneth Schikler, Hal Hoffman, Daniel J. Lovell, Robert Lipnick, Karyl Barron, John J. O'Shea, Daniel L. Kastner, and Raphaela Goldbach-Mansky

3349

Isolation and Characterization of Bone Marrow Multipotential Mesenchymal Progenitor Cells

Elena A. Jones, Sally E. Kinsey, Anne English, Richard A. Jones, Liz Straszynski, David M. Meredith, Alex F. Markham, Andrew Jack, Paul Emery, and Dennis McGonagle

3361

Inhibition of Adjuvant-Induced Arthritis by Systemic Tissue Inhibitor of Metalloproteinases 4 Gene Delivery

Mahmut Y. Celiker, Nungavaram Ramamurthy, Jin-Wen Xu, Mingsheng Wang, Yangfu Jiang, Robert Greenwald, and Y. Eric Shi

3369

Peptide-Induced Suppression of Collagen-Induced Arthritis in HLA-DR1 Transgenic Mice

Linda K. Myers, Yoshihiko Sakurai, B. Tang, Xiaowen He, Edward F. Rosloniec, John M. Stuart, and Andrew H. Kang

3378

Relief of Inflammatory Pain in Rats by Local Use of the Selective P2X7 ATP Receptor Inhibitor, Oxidized ATP

Giacomo Dell'Antonio, Angelo Quattrini, Elena Dal Cin, Alessandro Fulgenzi, and Maria Elena Ferrero

3386

Investigation of Linkage on Chromosome 2q and Hand and Knee Osteoarthritis

Emma Gillaspy, Kristian Spreckley, Gillian Wallis, Michael Doherty, and Tim D. Spector

3388

Humanized Monoclonal Anti-Interleukin-6 Receptor Antibody for Treatment of Intractable Adult-Onset Still's Disease

Masahiro Iwamoto, Hiroyuki Nara, Daisuke Hirata, Seiji Minota, Norihiro Nishimoto, and Kazuyuki Yoshizaki

3390

The Value of Rheumatologists to Patients With Fibromyalgia: Comment on the Presidential Address by Weinblatt

Andrew J. Holman

3390

Reply

Michael E. Weinblatt

3390

Increased Osteoprotegerin and Decreased Pyridinoline Levels in Patients With Ankylosing Spondylitis: Comment on the Article by Gratacos et al

Ricardo Prado Golmia, Branca Dias Batista Sousa, and Morton Aaron Scheinberg

3392

Reply

Jordi Gratacos and Raimon Sanmarti

3392

Increased Cutaneous Reactions to Hydroxychloroquine (Plaquenil) Possibly Associated With Formulation Change: Comment on the Letter by Alarcon

M. Salido, B. Joven, D. P. D'Cruz, M. A. Khamashta, and G. R. V. Hughes

3396

Efficacy of Tumor Necrosis Factor [alpha] Blockade for Enthesitis in Spondylarthropathy: Comment on the Article by Marzo-Ortega et al

Ignazio Olivieri, Angela Padula, and Enrico Scarano

3398

Reply

Helena Marzo-Ortega, Dennis McGonagle, and Paul Emery

3398

Erratum

3398

Author's Name Omitted From Article by Aganna et al (Arthritis Rheum, September 2002)

3399

Second-Year Fellow Abstracts and Late Breaking Abstracts, American College of Rheumatology 2002 Annual Scientific Meeting

3422

Reviewers

3427

Contents, Volume 46, 2002

3461

Indexes

Cover image: The figure on the cover (from Kusunoki et al, page  3164) demonstrates the occurrence of apoptosis in rheumatoid synovial  fibroblasts treated with celecoxib. The brown cells are apoptotic as shown by TUNEL staining. This finding suggests an action of celecoxib  that is not dependent on cyclooxygenase 2 inhibition and may be relevant to the activity of this drug in the treatment of rheumatoid arthritis.