2831

Editorial: Et Tu, Acetaminophen?

Steven B. Abramson

2836

Editorial: Predictors and Outcomes of Scleroderma Renal Crisis: Data From the High-Dose Versus Low-Dose D-Penicillamine in Early Diffuse Systemic Sclerosis Trial

Vibeke Strand

2838

Long-Term Safety and Maintenance of Clinical Improvement Following Treatment With Anakinra (Recombinant Human Interleukin-1 Receptor Antagonist) in Patients With Rheumatoid Arthritis: Extension Phase of a Randomized, Double-Blind, Placebo-Controlled Trial

George Nuki, Barry Bresnihan, Moraye B. Bear, and Dorothy McCabe, for the European Group of Clinical Investigators

2847

Association of Baseline Levels of Markers of Bone and Cartilage Degradation With Long-Term Progression of Joint Damage in Patients With Early Rheumatoid Arthritis: The COBRA Study

Patrick Garnero, Robert Landewe, Maarten Boers, Arco Verhoeven, Sjef van der Linden, Stephan Christgau, Desiree van der Heijde, Annelies Boonen, and Piet Geusens

2857

Cell-Derived Microparticles in Synovial Fluid From Inflamed Arthritic Joints Support Coagulation Exclusively Via a Factor VII-Dependent Mechanism

Rene J. Berckmans, Rienk Nieuwland, Paul Peter Tak, Anita N. Boing, Fred P. H. T. M. Romijn, Maarten C. Kraan, Ferdinand C. Breedveld, C. Erik Hack, and Augueste Sturk

2867

Regulation of Fibronectin and Metalloproteinase Expression by Wnt Signaling in Rheumatoid Arthritis Synoviocytes

Malini Sen, Jack Reifert, Kevin Lauterbach, Vladimir Wolf, Jeffrey S. Rubin, Maripat Corr, and Dennis A. Carson

2878

Migration of CX3CR1-Positive T Cells Producing Type 1 Cytokines and Cytotoxic Molecules Into the Synovium of Patients With Rheumatoid Arthritis

Toshihiro Nanki, Toshio Imai, Kenji Nagasaka, Yasuyo Urasaki, Yoshinori Nonomura, Ken Taniguchi, Kenji Hayashida, Jun Hasegawa, Osamu Yoshie, and Nobuyuki Miyasaka

2884

Risk Factors for Progressive Cartilage Loss in the Knee: A Longitudinal Magnetic Resonance Imaging Study in Forty-Three Patients

Sandip Biswal, Trevor Hastie, Thomas P. Andriacchi, Gabrielle A. Bergman, Michael F. Dillingham, and Philipp Lang

2893

Clinical Benefit of Joint Distraction in the Treatment of Severe Osteoarthritis of the Ankle: Proof of Concept in an Open Prospective Study and in a Randomized Controlled Study

Anne C. A. Marijnissen, Peter M. van Roermund, Jan van Melkebeek, Willem Schenk, Abraham J. Verbout, Johannes W. J. Bijlsma, and Floris P. J. G. Lafeber

2903

Matrix Homeostasis in Aging Normal Human Ankle Cartilage

Matthias Aurich, A. Robin Poole, Agnes Reiner, Christine Mollenhauer, Arkady Margulis, Klaus E. Kuettner, and Ada A. Cole

2911

Replicative Aging of Human Articular Chondrocytes During Ex Vivo Expansion

Dominik Parsch, Tim H. Brummendorf, Wiltrud Richter, and J|f-rg Fellenberg

2917

Hematopoietic Stem Cell Transplantation for Severe and Refractory Lupus: Analysis After Five Years and Fifteen Patients

Ann E. Traynor, Walter G. Barr, Robert M. Rosa, Julianne Rodriguez, Yu Oyama, Steven Baker, Mary Brush, and Richard K. Burt

2924

Dehydroepiandrosterone Treatment of Women With Mild-to-Moderate Systemic Lupus Erythematosus: A Multicenter Randomized, Double-Blind, Placebo-Controlled Trial

Deh-Ming Chang, Joung-Liang Lan, Hsiao-Yi Lin, and Shue-Fen Luo

2928

Linkage and Interaction of Loci on 1q23 and 16q12 May Contribute to Susceptibility to Systemic Lupus Erythematosus

Betty P. Tsao, Rita M. Cantor, Jennifer M. Grossman, Sung K. Kim, Noel Strong, Chak S. Lau, Chung-Jen Chen, Nan Shen, Ellen M. Ginzler, Rose Goldstein, Kenneth C. Kalunian, Frank C. Arnett, Daniel J. Wallace, and Bevra H. Hahn

2937

Stratification of Pedigrees Multiplex for Systemic Lupus Erythematosus and for Self-Reported Rheumatoid Arthritis Detects a Systemic Lupus Erythematosus Susceptibility Gene (SLER1) at 5p15.3

Bahram Namjou, Swapan K. Nath, Jeff Kilpatrick, Jennifer A. Kelly, Jeff Reid, Judith A. James, and John B. Harley

2946

Autoimmune Responses to Proliferating Cell Nuclear Antigen Multiprotein Complexes Involved in Cell Proliferation Are Strongly Associated With Their Structure and Biologic Function in Patients With Systemic Lupus Erythematosus

Toshiaki Kogure, Yoshinari Takasaki, Ken Takeuchi, Hirofumi Yamada, Masuyuki Nawata, Keigo Ikeda, Masakazu Matsushita, Ran Matsudaira, Kazuhiko Kaneda, Katsutoshi Terasawa, and Hiroshi Hashimoto

2957

Autoantibodies to Lipoprotein Lipase and Dyslipidemia in Systemic Lupus Erythematosus

Morris Reichlin, James Fesmire, Ana I. Quintero-Del-Rio, and Marianne Wolfson-Reichlin

2964

Fast Spin Echo-T2-Weighted Sequences With Fat Saturation in Dactylitis of Spondylarthritis: No Evidence of Entheseal Involvement of the Flexor Digitorum Tendons

Ignazio Olivieri, Carlo Salvarani, Fabrizio Cantini, Enrico Scarano, Angela Padula, Laura Niccoli, Giovanni Ciancio, and Libero Barozzi

2968

Association of Ankylosing Spondylitis With HLA-B*1403 in a West African Population

Carlos Lopez-Larrea, Moustafa Mijiyawa, Segundo Gonzalez, J. Luis Fernandez-Morera, Miguel A. Blanco-Gelaz, Jesus Martinez-Borra, and Antonio Lopez-Vazquez

2972

Cell-Surface Expression and Immune Receptor Recognition of HLA-B27 Homodimers

Simon Kollnberger, Lucy Bird, Mei-Yi Sun, Christelle Retiere, Veronique M. Braud, Andrew McMichael, and Paul Bowness

2983

Predictors and Outcomes of Scleroderma Renal Crisis: The High-Dose Versus Low-Dose D-Penicillamine in Early Diffuse Systemic Sclerosis Trial

Paul J. DeMarco, Michael H. Weisman, James R. Seibold, Daniel E. Furst, Weng Kee Wong, Eric L. Hurwitz, Maureen Mayes, Barbara White, Fredrick Wigley, Walter Barr, Larry Moreland, Thomas A. Medsger, Jr., Virginia Steen, Richard W. Martin, David Collier, Arthur Weinstein, Edward Lally, John Varga, Steven R. Weiner, Brian Andrews, Micha Abeles, and Philip J. Clements

2990

Association of Novel Polymorphisms With the Expression of SPARC in Normal Fibroblasts and With Susceptibility to Scleroderma

Xiaodong Zhou, Filemon K. Tan, John D. Reveille, Debra Wallis, Dianna M. Milewicz, Chul Ahn, Andrew Wang, and Frank C. Arnett

3000

Transforming Growth Factor [beta] Induces Fibroblast Fibrillin-1 Matrix Formation

Eugene Y. Kissin, Raphael Lemaire, Joseph H. Korn, and Robert Lafyatis

3010

Interleukin-15 Inhibits Sodium Nitroprusside-Induced Apoptosis of Synovial Fibroblasts and Vascular Endothelial Cells

Lin Yang, Sherry Thornton, and Alexei A. Grom3010

3015

Self Epitopes Shared Between Human Skeletal Myosin and Streptococcus pyogenes M5 Protein Are Targets of Immune Responses in Active Juvenile Dermatomyositis

Margherita Massa, Nick Costouros, Federica Mazzoli, Fabrizio De Benedetti, Antonio La Cava, Tho Le, Isme de Kleer, Angelo Ravelli, Margaret Liotta, Sarah Roord, Charles Berry, Lauren M. Pachman, Alberto Martini, and Salvatore Albani

3026

Safe Disposal of Inflammatory Monosodium Urate Monohydrate Crystals by Differentiated Macrophages

R. Clive Landis, Darshna R. Yagnik, Oliver Florey, Pandelis Philippidis, Vivien Emons, Justin C. Mason, and Dorian O. Haskard

3034

Ciprofloxacin Enhances the Stimulation of Matrix Metalloproteinase 3 Expression by Interleukin-1[beta] in Human Tendon-Derived Cells: A Potential Mechanism of Fluoroquinolone-Induced Tendinopathy

Anthony N. Corps, Rebecca L. Harrall, Valerie A. Curry, Steven A. Fenwick, Brian L. Hazleman, and Graham P. Riley

3041

CARD15 Mutations in Familial Granulomatosis Syndromes: A Study of the Original Blau Syndrome Kindred and Other Families With Large-Vessel Arteritis and Cranial Neuropathy

Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Lysette Mutkus, Ulrike Mau, Edward Blau, Naohiro Inohara, Gabriel Nunez, Gerard Tromp, and Charlene J. Williams

3046

Determinants and Sequelae Associated With Utilization of Acetaminophen Versus Traditional Nonsteroidal Antiinflammatory Drugs in an Elderly Population

Elham Rahme, Dan Pettitt, and Jacques LeLorier

3055

Increase in Expression of Receptor Activator of Nuclear Factor [Kappa]B at Sites of Bone Erosion Correlates With Progression of Inflammation in Evolving Collagen-Induced Arthritis

Erik Lubberts, Birgitte Oppers-Walgreen, Allison R. Pettit, Liduine van den Bersselaar, Leo A. B. Joosten, Steven R. Goldring, Ellen M. Gravallese, and Wim B. van den Berg

3065

Mechanisms of Effects of Complement Inhibition in Murine Collagen-Induced Arthritis

Nirmal K. Banda, Damian Kraus, Andrea Vondracek, Long H. Huynh, Alison Bendele, V. Michael Holers, and William P. Arend

3076

Spinal Adenosine Receptor Activation Inhibits Inflammation and Joint Destruction in Rat Adjuvant-Induced Arthritis

David L. Boyle, James Moore, Li Yang, Linda S. Sorkin, and Gary S. Firestein

3083

Correlation of Renal Tubular Epithelial Cell-Derived Interleukin-18 Up-Regulation With Disease Activity in MRL-Faslpr Mice With Autoimmune Lupus Nephritis

Justus Faust, Julia Menke, Jorg Kriegsmann, Vicki Rubin Kelley, Werner J. Mayet, Peter R. Galle, and Andreas Schwarting

3096

Tumor Necrosis Factor Receptor Type II (Exon 6) and Interleukin-6 (-174) Gene Polymorphisms Are Not Associated With Family History but Tumor Necrosis Factor Receptor Type II Is Associated With Hypertension in Patients With Rheumatoid Arthritis From Northern Sweden

Solbritt Rantapaa Dahlqvist, Lisbeth Arlestig, Carin Sikstrom, and Solveig Linghult

3098

Comparison of a Disease-Specific and a Generic Instrument for Measuring Health-Related Quality of Life in Ankylosing Spondylitis

Philip S. Helliwell, Helena Marzo-Ortega, and Alan Tennant

3099

Detection of Parvovirus B19 DNA by Polymerase Chain Reaction in Giant Cell Arteritis: A Case-Control Study

Carlo Salvarani, Enrico Farnetti, Bruno Casali, Davide Nicoli, Liu Wenlan, GianLuigi Bajocchi, PierLuigi Macchioni, Giovanni Lo Scocco, Maria Grazia Catanoso, Luigi Boiardi, and Fabrizio Cantini

3102

Aspirin Antiplatelet Therapy and Nonsteroidal Antiinflammatory Drugs: Comment on the 2002 Update of the American College of Rheumatology Guidelines for the Management of Rheumatoid Arthritis

Jose L. Pablos

3102

Hidden Hazards and Practical Problems: Comment on the 2002 Update of the American College of Rheumatology Guidelines for the Management of Rheumatoid Arthritis

Sidney R. Block

3103

Reply

C. Kent Kwoh, Larry G. Anderson, Jerry M. Greene, Dorothy A. Johnson, James R. O'Dell, Mark L. Robbins, W. Neal Roberts, Jr., Robert W. Simms, and Robert A. Yood

3104

Intolerance to Caffeine May Increase Susceptibility to Rheumatoid Arthritis: Comment on the Article by Mikuls et al

Hugh McGrath, Jr.

3104

Reply

Ted R. Mikuls, James R. Cerhan, Lindsey A. Criswell, Linda A. Merlino, and Kenneth G. Saag

3105

Importance of T cells in Rheumatoid Synovitis: Comment on the Review by Firestein and Zvaifler

Jonathan C. W. Edwards

3106

Reply

Gary S. Firestein and Nathan J. Zvaifler

3107

Genetic Drift as an Explanation for the Reduced Incidence of Rheumatoid Arthritis

Tom W. J. Huizinga, Suzanne Linn-Rasker, Leroy R. Lard, and Rudi G. J. Westendorp

3107

Successful Rechallenge With Anti-Tumor Necrosis Factor [alpha] for Psoriatic Arthritis After Development of Demyelinating Nervous System Disease During Initial Treatment: Comment on the Article by Mohan et al

Marcela Cisternas, Miguel Gutierrez, and Sergio Jacobelli

3108

Reply

Niveditha Mohan and Thomas R. Cupps

3109

A Nonsense Mutation in Exon 2 of the DNase I Gene Is Not Present in UK Subjects With Systemic Lupus Erythematosus and Graves' Disease: Comment on the Article by Rood et al

Matthew J. Simmonds, Joanne M. Heward, M. Ann Kelly, Amit Allahabadia, Helen Foxall, Caroline Gordon, Jayne A. Franklyn, and Stephen C. L. Gough

3110

Antioxidant Treatment Decreases the Titer of Circulating Anticardiolipin Antibodies: Comment on the Article by Sambo et al

D. Ferro, L. Iuliano, F. Violi, G. Valesini, and F. Conti

3112

Role of T Cells in the Pathogenesis of Osteoarthritis

Lazaros I. Sakkas and Chris D. Platsoucas

3113

Benefit or Risk of Aspirin Treatment of Giant Cell Arteritis: Comment on the Article by Weyand et al

Bruce M. Rothschild

3113

Reply

Cornelia M. Weyand and Jorg J. Goronzy

17A

Cover image: The figure on the cover (from Olivieri et al, page 2966) shows an axial spin-echo T2-weighted magnetic resonance image with fat suppression, of the fingers of a patient with dactylitis from spondylarthropathy. Fluid collections in the flexor synovial sheaths and subcutaneous edema are present.