2549

Editorial: Can Serum Biomarker Assays Measure the Progression of Cartilage Degeneration in Osteoarthritis?

A. Robin Poole

2553

Review: Glucocorticoids and Rheumatoid Arthritis: Back to the Future?

Larry W. Moreland and James R. O'Dell

2564

In Memoriam: E. Carwile LeRoy, MD, 1933-2002

Richard M. Silver

2565

Life-Threatening Histoplasmosis Complicating Immunotherapy With Tumor Necrosis Factor [alpha] Antagonists Infliximab and Etanercept

Jong-Hoon Lee, Nancy R. Slifman, Sharon K. Gershon, Evelyne T. Edwards, William D. Schwieterman, Jeffrey N. Siegel, Robert P. Wise, S. Lori Brown, John N. Udall, Jr., and M. Miles Braun

2571

Rapid and Complete Resolution of Proteinuria Due to Renal Amyloidosis in a Patient With Rheumatoid Arthritis Treated With Infliximab

Ori Elkayam, Philip N. Hawkins, Helen Lachmann, Michael Yaron, and Dan Caspi

2574

Cachexia in Rheumatoid Arthritis Is Not Explained by Decreased Growth Hormone Secretion

Laura C. Rall, Joseph M. Walsmith, Laura Snydman, Seymour Reichlin, Johannes D. Veldhuis, Joseph J. Kehayias, Leslie W. Abad, Nancy T. Lundgren, and Ronenn Roubenoff

2578

CD14+,CD16+ Blood Monocytes and Joint Inflammation in Rheumatoid Arthritis

Norikuni Kawanaka, Masahiro Yamamura, Tetsushi Aita, Yoshitaka Morita, Akira Okamoto, Masanori Kawashima, Mitsuhiro Iwahashi, Akiko Ueno, Yasukazu Ohmoto, and Hirofumi Makino

2587

Hypoxia-Induced Production of Stromal Cell-Derived Factor 1 (CXCL12) and Vascular Endothelial Growth Factor by Synovial Fibroblasts

Carol Hitchon, Keng Wong, Guoping Ma, Jennifer Reed, David Lyttle, and Hani El-Gabalawy

2598

High Mobility Group Box Chromosomal Protein 1: A Novel Proinflammatory Mediator in Synovitis

R. Kokkola, E. Sundberg, A.-K. Ulfgren, K. Palmblad, J. Li, H. Wang, L. Ulloa, H. Yang, X.-J. Yan, R. Furie, N. Chiorazzi, K. J. Tracey, U. Andersson, and H. Erlandsson Harris

2604

Inhibition of Interleukin-1 but Not Tumor Necrosis Factor Suppresses Neovascularization in Rat Models of Corneal Angiogenesis and Adjuvant Arthritis

Angela Coxon, Brad Bolon, Juan Estrada, Stephen Kaufman, Sheila Scully, Alana Rattan, Diane Duryea, Yi-Ling Hu, Karen Rex, Efrain Pacheco, Gwyneth Van, Debra Zack, and Ulrich Feige

2613

Uncoupling of Type II Collagen Synthesis and Degradation Predicts Progression of Joint Damage in Patients With Knee Osteoarthritis

Patrick Garnero, Xavier Ayral, Jean-Charles Rousseau, S. Christgau, Linda J. Sandell, Maxime Dougados, and Pierre D. Delmas

2625

Significant Increases in Serum and Plasma Concentrations of Matrix Metalloproteinases 3 and 9 in Patients With Rapidly Destructive Osteoarthritis of the Hip

Kensaku Masuhara, Tsuyoshi Nakai, Katsuyuki Yamaguchi, Satoshi Yamasaki, and Yasuyuki Sasaguri

2632

The Influence of Alignment on Risk of Knee Osteoarthritis Progression According to Baseline Stage of Disease

Rui Cerejo, Dorothy D. Dunlop, September Cahue, David Channin, Jing Song, and Leena Sharma

2637

The In Situ Up-Regulation of Chondrocyte Interleukin-1-Converting Enzyme and Interleukin-18 Levels in Experimental Osteoarthritis Is Mediated by Nitric Oxide

Christelle Boileau, Johanne Martel-Pelletier, Florina Moldovan, Jean-Yves Jouzeau, Patrick Netter, Pamela T. Manning, and Jean-Pierre Pelletier

2648

Relative Messenger RNA Expression Profiling of Collagenases and Aggrecanases in Human Articular Chondrocytes In Vivo and In Vitro

Brigitte Bau, Pia M. Gebhard, Jochen Haag, Thomas Knorr, Eckart Bartnik, and Thomas Aigner

2658

Human Intervertebral Disc Aggrecan Inhibits Nerve Growth In Vitro

William E. B. Johnson, Bruce Caterson, Stephen M. Eisenstein, Dianna L. Hynds, Diane M. Snow, and Sally Roberts

2665

Association of Global Brain Damage and Clinical Functioning in Neuropsychiatric Systemic Lupus Erythematosus

G. P. Th. Bosma, H. A. M. Middlekoop, M. J. Rood, E. L. E. M. Bollen, T. W. J. Huizinga, and M. A. van Buchem

2673

An Open Study of B Lymphocyte Depletion in Systemic Lupus Erythematosus

Maria J. Leandro, Jonathan C. Edwards, Geraldine Cambridge, Michael R. Ehrenstein, and David A. Isenberg

2678

Familiality and Co-Occurrence of Clinical Features of Systemic Lupus Erythematosus

Betty P. Tsao, Jennifer M. Grossman, Gabriela Riemekasten, Noel Strong, Jatinderpal Kalsi, Daniel J. Wallace, Chung-Jen Chen, Chak S. Lau, Ellen M. Ginzler, Rose Goldstein, Kenneth C. Kalunian, John B. Harley, Frank C. Arnett, Bevra H. Hahn, and Rita M. Cantor

2686

Antibodies to High-Density Lipoprotein and [beta]2-Glycoprotein I Are Inversely Correlated With Paraoxonase Activity in Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome

J. Delgado Alves, P. R. J. Ames, S. Donohue, L. Stanyer, J. Noorouz-Zadeh, C. Ravirajan, and D. A. Isenberg

2695

Association of Autoantibodies to Nuclear Lamin B1 With Thromboprotection in Systemic Lupus Erythematosus: Lack of Evidence for a Direct Role of Lamin B1 in Apoptotic Blebs

Melanie Dieude, Jean-Luc Senecal, Joyce Rauch, John G. Hanly, Paul Fortin, Nathalie Brassard, and Yves Raymond

2708

The Early Pattern of Joint Involvement Predicts Disease Progression in Children With Oligoarticular (Pauciarticular) Juvenile Rheumatoid Arthritis

Mohammad J. Al-Matar, Ross E. Petty, Lori B. Tucker, Peter N. Malleson, Maria-Louise Schroeder, and David A. Cabral

2716

Evidence for Linkage of HLA Loci in Juvenile Idiopathic Oligoarthritis: Independent Effects of HLA-A and HLA-DRB1

Eleftheria Zeggini, Rachelle P. Donn, William E. R. Ollier, Wendy Thomson, and The British Paediatric Rheumatology Study Group

2721

Proinflammatory Responses to Self HLA Epitopes Are Triggered by Molecular Mimicry to Epstein-Barr Virus Proteins in Oligoarticular Juvenile Idiopathic Arthritis

Margherita Massa, Federica Mazzoli, Patrizia Pignatti, Fabrizio De Benedetti, Maristella Passalia, Stefania Viola, Rodrigo Samodal, Antonio La Cava, Francesca Giannoni, W. Ollier, Alberto Martini, and Salvatore Albani

2730

Involvement of the Interferon-[gamma]-Induced T Cell-Attracting Chemokines, Interferon-[gamma]-Inducible 10-kd Protein (CXCL10) and Monokine Induced by Interferon-[gamma] (CXCL9), in the Salivary Gland Lesions of Patients With Sjogren's Syndrome

Noriyoshi Ogawa, Li Ping, Li Zhenjun, Yukiko Takada, and Susumu Sugai

2742

Identification of an Immunodominant Epitope on RNA Polymerase III Recognized by Systemic Sclerosis Sera: Application to Enzyme-Linked Immunosorbent Assay

Masataka Kuwana, Kyoko Kimura, and Yutaka Kawakami

2748

Halofuginone Inhibition of COL1A2 Promoter Activity Via a c-Jun-Dependent Mechanism

Tracy L. McGaha, Takao Kodera, Harry Spiera, Alexandru C. Stan, Mark Pines, and Constantin A. Bona

2762

Symptomatic Macroglossia and Tongue Myositis in Polymyositis: Treatment With Corticosteroids and Intravenous Immunoglobulin

E. Chauvet, L. Sailler, M. Carreiro, J. R. Paoli, P. Arrue, L. Astudillo, F. Oksmann, M. B. Delisle, and Ph. Arlet

2765

Activation of Melanocortin Type 3 Receptor as a Molecular Mechanism for Adrenocorticotropic Hormone Efficacy in Gouty Arthritis

Stephen J. Getting, Helen C. Christian, Roderick J. Flower, and Mauro Perretti

2776

Alefacept Treatment in Psoriatic Arthritis: Reduction of the Effector T Cell Population in Peripheral Blood and Synovial Tissue Is Associated With Improvement of Clinical Signs of Arthritis

Maarten C. Kraan, Arno W. R. van Kuijk, Huibert J. Dinant, Amber Y. Goedkoop, Tom J. M. Smeets, Menno A. de Rie, Ben A. C. Dijkmans, Akshay K. Vaishnaw, Jan D. Bos, and Paul P. Tak

2785

Reduced MEFV Messenger RNA Expression in Patients With Familial Mediterranean Fever

Cecile Notarnicola, Marie-Noelle Didelot, Isabelle Kone-Paut, Fabienne Seguret, Jacques Demaille, and Isabelle Touitou

2794

Lack of Isoprenoid Products Raises Ex Vivo Interleukin-1[beta] Secretion in Hyperimmunoglobulinemia D and Periodic Fever Syndrome

Joost Frenkel, Ger T. Rijkers, Saskia H. L. Mandey, Sandra W. M. Buurman, Sander M. Houten, Ronald J. A. Wanders, Hans R. Waterham, and Wietse Kuis

2804

Radiographic Healing With Sustained Clinical Remission in a Patient With Rheumatoid Arthritis Receiving Methotrexate Monotherapy

Siegfried Wassenberg and Rolf Rau

2808

Osteoid Osteoma of the Capitate

Andreas Schindler, Juerg Hodler, Beat A. Michel, and Pius Bruehlmann

2811

Absence of Inducible Retroviruses From Synovial Fibroblasts and Synovial Fluid Cells of Patients With Rheumatoid Arthritis

Christian A. Seemayer, Stefan A. Kolb, Michel Neidhart, Shiro Ohshima, Renate E. Gay, Beat A. Michel, Steffen Gay, Jurg Boni, and Jorg Schupbach

2814

Magnetic Resonance Imaging as a Predictor of Progressive Joint Destruction in Neuropathic Joint Disease

Adam S. Greenstein, Helena Marzo-Ortega, Paul Emery, Philip O'Connor, and Dennis McGonagle

2816

Crystal-Induced Arthritis Mimicking Rheumatoid Arthritis in a Patient With Monoclonal Gammopathy

H. Aarset, J. Dekker, S.-H. Brorson, and G. Husby

2817

Blocking Tumor Necrosis Factor Inhibits Radiographic Damage Even in Patients Who Show Minimal or No Clinical Improvement: Comment on the Concise Communication by Boers

Peter E. Lipsky, David T. Felson, and Ravinder N. Maini

2818

Reply

Maarten Boers

2820

Comment on the Reply by Boers

Peter E. Lipsky and Ravinder N. Maini

2821

Case Series of Selective Anti-Tumor Necrosis Factor [alpha] Therapy Using Infliximab in Patients With Nonresponsive Chronic HLA-B27-Associated Anterior Uveitis: Comment on the Articles by Brandt et al

Yosuf El-Shabrawi and Josef Hermann

2822

Reply

Jurgen Braun and Joachim Sieper

2824

Is Expression of Intracellular Citrullinated Proteins in Synovial Tissue Specific for Rheumatoid Arthritis? Comment on the Article by Baeten et al

T. J. M. Smeets, E. R. Vossenaar, W. J. van Venrooij, and P. P. Tak

2826

Reply

Dominique Baeten, Eric M. Veys, and Filip De Keyser

2827

Is Acquired C1 Inhibitor Deficiency Associated With Lupus a Distinct Disease Entity? Comment on the Article by Cacoub et al

Aamir Aslam and Siraj A. Misbah

2828

Reply

Patrice Cacoub and Veronique Fremeaux-Bacchi

2828

Is the Sp1 Polymorphism in the COL1A1 Gene a Risk Factor for Postmenopausal Osteoporosis? Comment on the Article by Keen et al

K. Zajickova, I. ofkova, and M. Hill

2829

Mutations of Bone Morphogenetic Protein Receptor Type II Are Not Found in Patients With Pulmonary Hypertension and Underlying Connective Tissue Diseases

Monty B. Tew, Frank C. Arnett, John D. Reveille, and Filemon K. Tan

2830

Author's Name Omitted From Article by Leask et al (Arthritis Rheum, July 2002)

19A

Cover image: The figure on the cover (from Wassenberg and Rau, page 2805) shows sequential radiographs of a metatarsophalangeal joint of a patient with rheumatoid arthritis treated with methotrexate. The first radiograph was obtained in 1997, and the second in 2000. As these radiographs indicate, effective disease-modifying antirheumatic drug therapy can have a significant impact on the erosive process, leading not only to cessation, but to repair. These findings are important with regard to the discussion of the effect of various disease-modifying antirheumatic drugs on tissue destruction and suggest that healing and remodeling may also occur with these agents.