2265

Editorial: Understanding the Dynamics Between Ethnicity and Health Care: Another Role for Health Services Research in Chronic Disease Management

John R. Feussner

2268

Review: Extravascular Coagulation and the Plasminogen Activator/Plasmin System in Rheumatoid Arthritis

Nathalie Busso and John A. Hamilton

2280

Conference Summary: Ethnic Health Disparities in Arthritis and Musculoskeletal Diseases: Report of a Scientific Conference

Joanne M. Jordan, Reva Lawrence, Raynard Kington, Patricia Fraser, Elizabeth Karlson, Kate Lorig, and Matthew H. Liang

2287

Frequency of Infection in Patients With Rheumatoid Arthritis Compared With Controls: A Population-Based Study

Michele F. Doran, Cynthia S. Crowson, Gregory R. Pond, W. Michael O'Fallon, and Sherine E. Gabriel

2294

Predictors of Infection in Rheumatoid Arthritis

Michele F. Doran, Cynthia S. Crowson, Gregory R. Pond, W. Michael O'Fallon, and Sherine E. Gabriel

2301

A Pilot Randomized Trial Comparing CD34-Selected Versus Unmanipulated Hemopoietic Stem Cell Transplantation for Severe, Refractory Rheumatoid Arthritis

John Moore, Peter Brooks, Sam Milliken, Jim Biggs, David Ma, Malcolm Handel, Paul Cannell, Rob Will, Simon Rule, David Joske, Bob Langlands, Kerry Taylor, Joe O'Callaghan, Jeff Szer, Ian Wicks, Geoff McColl, Frances Passeullo, and John Snowden

2310

Modeling the Progression of Rheumatoid Arthritis: A Two-Country Model to Estimate Costs and Consequences of Rheumatoid Arthritis

Gisela Kobelt, Linus Jonsson, Peter Lindgren, Adam Young, and Kerstin Eberhardt Tyson Holmes, and Bonnie Bruce

2320

HLA-DRB1 Genotype Associations in 793 White Patients From a Rheumatoid Arthritis Inception Cohort: Frequency, Severity, and Treatment Bias

James F. Fries, Frederick Wolfe, Raymond Apple, Henry Erlich, Teodorica Bugawan,

2330

CD13/Aminopeptidase N-Induced Lymphocyte Involvement in Inflamed Joints of Patients With Rheumatoid Arthritis

Teruki Shimizu, Kenji Tani, Kayoko Hase, Hirohisa Ogawa, Luping Huang, Fumio Shinomiya, and Saburo Sone

2339

Epitope-Specific Recognition of Type II Collagen by Rheumatoid Arthritis Antibodies Is Shared With Recognition by Antibodies That Are Arthritogenic in Collagen-Induced Arthritis in the Mouse

Harald Burkhardt, Tobias Koller, Ake Engstrom, Kutty Selva Nandakumar, Javier Turnay, Hans G. Kraetsch, Joachim R. Kalden, and Rikard Holmdahl

2349

Detection of Nitrotyrosine in Aging and Osteoarthritic Cartilage: Correlation of Oxidative Damage With the Presence of Interleukin-1[beta] and With Chondrocyte Resistance to Insulin-Like Growth Factor 1

Richard F. Loeser, Cathy S. Carlson, Marcello Del Carlo, and Ada Cole

2358

The Insulin-Like Growth Factor Binding Proteins in Uncultured Human Cartilage: Increases in Insulin-Like Growth Factor Binding Protein 3 During Osteoarthritis

Teresa I. Morales

2368

Fibronectin Fragments and Blocking Antibodies to [alpha]2[beta]1 and [alpha]5[beta]1 Integrins Stimulate Mitogen-Activated Protein Kinase Signaling and Increase Collagenase 3 (Matrix Metalloproteinase 13) Production by Human Articular Chondrocytes

Christopher B. Forsyth, Judit Pulai, and Richard F. Loeser

2377

Long-Term Followup of Children With Neonatal Lupus and Their Unaffected Siblings

Victor Martin, Lela A. Lee, Anca D. Askanase, Margaret Katholi, and Jill P. Buyon

2384

Autoantibodies Against Granulocyte Colony-Stimulating Factor in Felty's Syndrome and Neutropenic Systemic Lupus Erythematosus

Bernhard Hellmich, Elena Csernok, Helmut Schatz, Wolfgang L. Gross, and Armin Schnabel

2392

Long-Term Outcome in Patients With Juvenile Idiopathic Arthritis

Kirsten Minden, Martina Niewerth, Joachim Listing, Thomas Biedermann, Matthias Bollow, Monika Schntube, and Angela Zink

2402

Mutation Screening of the Macrophage Migration Inhibitory Factor Gene: Positive Association of a Functional Polymorphism of Macrophage Migration Inhibitory Factor With Juvenile Idiopathic Arthritis

Rachelle Donn, Zaynab Alourfi, Fabrizio De Benedetti, Cristina Meazza, Eleftheria Zeggini, Mark Lunt, Adam Stevens, Emma Shelley, Rebecca Lamb, the British Paediatric Rheumatology Study Group, William E. R. Ollier, Wendy Thomson, and David Ray

2410

Measuring Disease Activity and Functional Status in Patients With Scleroderma and Raynaud's Phenomenon

Peter A. Merkel, Karen Herlyn, Richard W. Martin, Jennifer J. Anderson, Maureen D. Mayes, Patrice Bell, Joseph H. Korn, Robert W. Simms, Mary Ellen Csuka, Thomas A. Medsger, Jr., Naomi F. Rothfield, Michael H. Ellman, David H. Collier, Arthur Weinstein, Daniel E. Furst, Sergio A. Jimenez, Barbara White, James R. Seibold, and Fredrick M. Wigley, for the Scleroderma Clinical Trials Consortium

2421

Increased Transcriptional Activities of Transforming Growth Factor [beta] Receptors in Scleroderma Fibroblasts

Kenichi Yamane, Hironobu Ihn, Masahide Kubo, and Kunihiko Tamaki

2429

Differences in Expectations of Outcome Mediate African American/White Patient Differences in ``Willingness'' to Consider Joint Replacement

Said A. Ibrahim, Laura A. Siminoff, Christopher J. Burant, and C. Kent Kwoh

2436

Contribution of Hospital Characteristics to the Volume-Outcome Relationship: Dislocation and Infection Following Total Hip Replacement Surgery

Daniel H. Solomon, Elena Losina, John A. Baron, Anne H. Fossel, Edward Guadagnoli, Elizabeth A. Lingard, Andrew Miner, Charlotte B. Phillips, and Jeffrey N. Katz

2445

Association of Mutations in the NALP3/CIAS1/PYPAF1 Gene With a Broad Phenotype Including Recurrent Fever, Cold Sensitivity, Sensorineural Deafness, and AA Amyloidosis

Ebun Aganna, Fabio Martinon, Philip N. Hawkins, John B. Ross, Daniel C. Swan, David R. Booth, Helen J. Lachmann, Roxanne Gaudet, Patricia Woo, Conleth Feighery, Finbarr E. Cotter, Margot Thome, Graham A. Hitman, Jurg Tschopp, and Michael F. McDermott

2453

Reduced Susceptibility to Collagen-Induced Arthritis in DBA/1J Mice Expressing the TSG-6 Transgene

C. Mindrescu, A. A. M. Dias, R. J. Olszewski, M. J. Klein, L. F. L. Reis, and H.-G. Wisniewski

2465

Mice Lacking Endogenous Major Histocompatibility Complex Class II Develop Arthritis Resembling Psoriatic Arthritis at an Advanced Age

Tamas Bardos, Jian Zhang, Katalin Mikecz, Chella S. David, and Tibor T. Glant

2476

Antiarthritic Activity of an Orally Active C5a Receptor Antagonist Against Antigen-Induced Monarticular Arthritis in the Rat

Trent M. Woodruff, Anna J. Strachan, Nathan Dryburgh, Ian A. Shiels, Robert C. Reid, David P. Fairlie, and Stephen M. Taylor

2486

Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Mediates Leukocyte Infiltration and Articular Cartilage Destruction in Rat Zymosan-Induced Arthritis

Takefumi Nakagawa, Masao Akagi, Hajime Hoshikawa, Mingyi Chen, Tadashi Yasuda, Shogo Mukai, Kunitaka Ohsawa, Tomoh Masaki, Takashi Nakamura, and Tatsuya Sawamura

2495

Effect of Oral Glucosamine on Cartilage and Meniscus in Normal and Chymopapain-Injected Knees of Young Rabbits

Theodore R. Oegema, Jr., Laurel B. Deloria, John D. Sandy, and David A. Hart

2504

Antiinflammatory Effect of Retrovirally Transfected Interleukin-10 on Monosodium Urate Monohydrate Crystal-Induced Acute Inflammation in Murine Air Pouches

Yousuke Murakami, Tohru Akahoshi, Shinichi Kawai, Matsuhisa Inoue, and Hidero Kitasato

2514

Adeno-Associated Virus-Mediated Osteoprotegerin Gene Transfer Protects Against Particulate Polyethylene-Induced Osteolysis in a Murine Model

Shang-You Yang, Lois Mayton, Bin Wu, J. Jeffrey Goater, Edward M. Schwarz, and Paul H. Wooley

2524

Tissue-Engineered Composites for the Repair of Large Osteochondral Defects

Dirk Schaefer, Ivan Martin, G. Jundt, Joachim Seidel, Michael Heberer, Alan Grodzinsky, Ingrid Bergin, Gordana Vunjak-Novakovic, and Lisa E. Freed

2535

HLA-DRB1*01 and Macrophagic Myofasciitis

Sandrine Guis, Jean-Francois Pellissier, Francois Nicoli, Denis Reviron, Jean-Pierre Mattei, Romain K. Gherardi, Jean Pelletier, Gilles Kaplanski, Dominique Figarella-Branger, and Jean Roudier

2537

A Hungry Histiocyte: Lupus-Related Hemophagocytic Syndrome

Michael S. Lloyd, Kelly J. Bethel, and Ken D. Pischel

2538

Microchimerism in Systemic Sclerosis: Comment on the Article by Johnson et al

P. J. Roberts-Thomson, J. G. Walker, P. Hakendorf, M. D. Smith, and M. J. Ahern

2538

Reply

K. L. Johnson, D. W. Bianchi, and J. L. Nelson

2539

Highly Elevated Serum Levels of Interleukin-18 in Systemic Juvenile Idiopathic Arthritis but Not in Other Juvenile Idiopathic Arthritis Subtypes or in Kawasaki Disease: Comment on the Article by Kawashima et al

Nobuaki Maeno, Syuji Takei, Yuichi Nomura, Hiroyuki Imanaka, Masashi Hokonohara, and Koichiro Miyata

2541

Reply

Masahiro Yamamura, Masanori Kawashima, and Hirofumi Makino

2542

Treatment With Gonadotropin-Releasing Hormone Agonists and Prevention of Multiple Gestations in Lupus or Antiphospholipid Syndrome Patients Undergoing In Vitro Fertilization: Comment on the Article by Guballa et al

Zeev Blumenfeld

2542

Reply

Michael D. Lockshin, Lisa R. Sammaritano, and Sergio Schwartzman

2543

Differentiation of Hyaluronate Products by Qualitative Differences in Their Immunogenicity in Rabbits: Possible Mechanism for Product-Specific Severe Adverse Reactions? Comment on the Article by Martens

William Bucher, Todd Otto, and Max I. Hamburger

2544

Reply

Peter B. Martens

2545

Silicone Breast Implants Do Not Cause Rheumatic Diseases, but Can They Influence Them?

Daniel J. Wallace

2545

Treatment of Fibromyalgia With Sibutramine Hydrochloride Monohydrate: Comment on the Article by Goldenberg et al

Mark Palangio, John A. Flores, and Steven V. Joyal

2546

Reply

Don Goldenberg and Tej Sandhu

2546

Use of Triamcinolone Hexacetonide for the Treatment of Osteoarthritis of the Hip: Comment on the Letter by Margules

Charles Kahn

2547

Reply

Kenneth R. Margules

2547

Laboratory Tests and ``Likelihood Ratios'': Comment on the Editorial by Kavanaugh

A. S. Russell

2547

Reply

Arthur Kavanaugh

2547

The Neural Network as a Predictor of Cancer in Patients With Inflammatory Myopathies

Albert Selva-O'Callaghan, Tilman Mijares-Boeckh-Behrens, Roser Solans-Laque, Moises Labrador-Horrillo, Enrique Romero-Merino, Jose M. Sopena-Sisquella, and Miquel Vilardell-Tarres

23A

Cover image: The figure on the cover (from Yang et al, page 2519) illustrates a histologic section from a bone-implanted air pouch system in the mouse, used to evaluate the effects of virus-mediated gene transfer with osteoprotegerin on particulate polyethylene-induced osteolysis. The section is stained with trichrome to show bone collagen content. This system is important in evaluating candidate molecules to treat or prevent debris-associated osteolysis and loosening of prostheses.