1981

Editorial: Choosing Treatment for Proliferative Lupus Nephritis

James E. Balow

1984

Editorial: B Cell-Ablative Therapy for the Treatment of Autoimmune Diseases

Dhavalkumar D. Patel

1986

Review: Apoptosis and Cellular Vitality: Issues in Osteoarthritic Cartilage Degeneration

T. Aigner and H. A. Kim

1997

Review: Pulmonary Hypertension in Autoimmune Rheumatic Diseases: Where Are We Now?

M. Magliano, D. A. Isenberg, and J. Hillson

2010

Mortality in Early Inflammatory Polyarthritis: Cardiovascular Mortality Is Increased in Seropositive Patients

Nicola J. Goodson, Nicola J. Wiles, Mark Lunt, Elizabeth M. Barrett, Alan J. Silman, and Deborah P. M. Symmons

2020

Efficacy of Tacrolimus in Rheumatoid Arthritis Patients Who Have Been Treated Unsuccessfully With Methotrexate: A Six-Month, Double-Blind, Randomized, Dose-Ranging Study

Daniel E. Furst, Kenneth Saag, M. Roy Fleischmann, Yvonne Sherrer, Joel A. Block, Thomas Schnitzer, Joel Rutstein, Andrew Baldassare, Jeffrey Kaine, Leonard Calabrese, Frederick Dietz, Marshall Sack, R. Gordon Senter, Craig Wiesenhutter, Michael Schiff, C. Michael Stein, Yoichi Satoi, Alan Matsumoto, Jacques Caldwell, Robert E. Harris, Larry W. Moreland, Eric Hurd, David Yocum, and David A. Stamler

2029

Efficacy of Selective B Cell Blockade in the Treatment of Rheumatoid Arthritis: Evidence for a Pathogenetic Role of B Cells

Salvatore De Vita, Francesco Zaja, Stefania Sacco, Alessandro De Candia, Renato Fanin, and Gianfranco Ferraccioli

2034

Comparison of Synovial Tissues From the Knee Joints and the Small Joints of Rheumatoid Arthritis Patients: Implications for Pathogenesis and Evaluation of Treatment

Maarten C. Kraan, Richard J. Reece, Tom J. M. Smeets, Douglas J. Veale, Paul Emery, and Paul P. Tak

2039

Association Between Tumor Necrosis Factor Receptor II and Familial, but Not Sporadic, Rheumatoid Arthritis: Evidence for Genetic Heterogeneity

Philippe Dieude, Elisabeth Petit, Severine Cailleau-Moindrault, Jose Osorio, Celine Pierlot, Maria Martinez, Sabine Faure, Olivier Alibert, Sandra Lasbleiz, Claudia de Toma, Thomas Bardin, Bernard Prum, and Francois Cornelis, for the European Consortium on Rheumatoid Arthritis Families

2045

Single-Nucleotide Polymorphisms in Tumor Necrosis Factor Receptor Genes: Definition of Novel Haplotypes and Racial/Ethnic Differences

S. Louis Bridges, Jr., Grace Jenq, Molly Moran, Tamara Kuffner, William C. Whitworth, and Janet McNicholl

2051

Detection of Antibodies to Deiminated Recombinant Rat Filaggrin by Enzyme-Linked Immunosorbent Assay: A Highly Effective Test for the Diagnosis of Rheumatoid Arthritis

Christian Vincent, Leonor Nogueira, Mireille Sebbag, Sabine Chapuy-Regaud, Michel Arnaud, Odile Letourneur, Dominique Rolland, Bernard Fournie, Alain Cantagrel, Michel Jolivet, and Guy Serre

2059

Influence of Epitopes CD44v3 and CD44v6 in the Invasive Behavior of Fibroblast-Like Synoviocytes Derived From Rheumatoid Arthritic Joints

Auragun Wibulswas, Daniel Croft, Andrew A. Pitsillides, Ian Bacarese-Hamilton, Peter McIntyre, Elisabeth Genot, and IJsbrand M. Kramer

2065

The Determinants of Change in Tibial Cartilage Volume in Osteoarthritic Knees

Anita E. Wluka, Stephen Stuckey, Judith Snaddon, and Flavia M. Cicuttini

2073

Knee Cartilage of Spinal Cord-Injured Patients Displays Progressive Thinning in the Absence of Normal Joint Loading and Movement

B. Vanwanseele, F. Eckstein, H. Knecht, E. Stussi, and A. Spaepen

2079

Epigallocatechin-3-Gallate Inhibits Interleukin-1[beta]-Induced Expression of Nitric Oxide Synthase and Production of Nitric Oxide in Human Chondrocytes: Suppression of Nuclear Factor [Kappa]B Activation by Degradation of the Inhibitor of Nuclear Factor [Kappa]B

Rashmi Singh, Salahuddin Ahmed, Najmul Islam, Victor M. Goldberg, and Tariq M. Haqqi

2087

Sites of Collagenase Cleavage and Denaturation of Type II Collagen in Aging and Osteoarthritic Articular Cartilage and Their Relationship to the Distribution of Matrix Metalloproteinase 1 and Matrix Metalloproteinase 13

William Wu, R. Clark Billinghurst, Isabelle Pidoux, John Antoniou, David Zukor, Michael Tanzer, and A. Robin Poole

2095

Light-Activated Gene Transduction Enhances Adeno-Associated Virus Vector-Mediated Gene Expression in Human Articular Chondrocytes

Michael Ulrich-Vinther, Michael D. Maloney, J. Jeffrey Goater, Kjeld S\oballe, Mary B. Goldring, Regis J. O'Keefe, and Edward M. Schwarz

2105

The Effects of Age and Sex on Chondroitin Sulfates in Normal Synovial Fluid

Yoshihito Nakayama, Tetsuya Narita, Atsushi Mori, Shinji Uesaka, Kyosuke Miyazaki, and Hiromoto Ito

2109

Identification of Synovium-Specific Homing Peptides by In Vivo Phage Display Selection

Lewis Lee, Christopher Buckley, Mark C. Blades, Gabriel Panayi, Andrew J. T. George, and Costantino Pitzalis

2121

Immunosuppressive Therapy in Lupus Nephritis: The Euro-Lupus Nephritis Trial, a Randomized Trial of Low-Dose Versus High-Dose Intravenous Cyclophosphamide

Frederic A. Houssiau, Carlos Vasconcelos, David D'Cruz, Gian Domenico Sebastiani, Enrique de Ramon Garrido, Maria Giovanna Danieli, Daniel Abramovicz, Daniel Blockmans, Alessandro Mathieu, Haner Direskeneli, Mauro Galeazzi, Ahmet Gul, Yair Levy, Peter Petera, Rajko Popovic, Radmila Petrovic, Renato Alberto Sinico, Roberto Cattaneo, Josep Font, Genevieve Depresseux, Jean-Pierre Cosyns, and Ricard Cervera

2132

Genetic Linkage and Association of Fc[gamma] Receptor IIIA (CD16A) on Chromosome 1q23 With Human Systemic Lupus Erythematosus

Jeffrey C. Edberg, Carl D. Langefeld, Jianming Wu, Kathy L. Moser, Kenneth M. Kaufman, Jennifer Kelly, Vipin Bansal, W. Mark Brown, Jane E. Salmon, Stephen S. Rich, John B. Harley, and Robert P. Kimberly

2141

T Cell Receptor Repertoire of T Cells in the Kidneys of Patients With Lupus Nephritis

Hideyuki Murata, Ryutaro Matsumura, Akio Koyama, Takao Sugiyama, Makoto Sueishi, Kazuko Shibuya, Akito Tsutsumi, and Takayuki Sumida

2148

Autoantibody to c-Mpl (Thrombopoietin Receptor) in Systemic Lupus Erythematosus: Relationship to Thrombocytopenia With Megakaryocytic Hypoplasia

Masataka Kuwana, Yuka Okazaki, Mikio Kajihara, Junichi Kaburaki, Hiroshi Miyazaki, Yutaka Kawakami, and Yasuo Ikeda

2160

Diminished Peripheral Blood Memory B Cells and Accumulation of Memory B Cells in the Salivary Glands of Patients With Sjogren's Syndrome

Arne Hansen, Marcus Odendahl, Karin Reiter, Annett M. Jacobi, Eugen Feist, Jurgen Scholze, Gerd R. Burmester, Peter E. Lipsky, and Thomas Dorner

2172

HLA-B27 Modulates Nuclear Factor [Kappa]B Activation in Human Monocytic Cells Exposed to Lipopolysaccharide

Markus A. Penttinen, Carina I. Holmberg, Lea Sistonen, and Kaisa Granfors

2181

The Enlarging Clinical, Genetic, and Population Spectrum of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome

Catherine Dode, Marc Andre, Thierry Bienvenu, Pierre Hausfater, Christophe Pecheux, Jacques Bienvenu, Jean-Claude Lecron, Philippe Reinert, Daniel Cattan, Jean-Charles Piette, Marie-France Szajnert, Marc Delpech, Gilles Grateau, and the French Hereditary Recurrent Inflammatory Disorder Study Group

2189

Monocytic Fasciitis: A Newly Recognized Clinical Feature of Tumor Necrosis Factor Receptor Dysfunction

Keith M. Hull, Kondi Wong, Geryl M. Wood, Wei-Sing Chu, and Daniel L. Kastner

2195

Underutilization of Gastroprotective Measures in Patients Receiving Nonsteroidal Antiinflammatory Drugs

Walter Smalley, C. Michael Stein, Patrick G. Arbogast, Glenn Eisen, Wayne A. Ray, and Marie Griffin

2201

The Safety of Celecoxib in Patients With Aspirin-Sensitive Asthma

Katharine M. Woessner, Ronald A. Simon, and Donald D. Stevenson

2207

Cartilage-Specific Constitutive Expression of TSG-6 Protein (Product of Tumor Necrosis Factor [alpha]-Stimulated Gene 6) Provides a Chondroprotective, but Not Antiinflammatory, Effect in Antigen-Induced Arthritis

Tibor T. Glant, Rajesh V. Kamath, Tamas Bardos, Istvan Gal, Sandor Szanto, Yanal M. Murad, John D. Sandy, John S. Mort, Peter J. Roughley, and Katalin Mikecz

2219

Reduction of CpG-Induced Arthritis by Suppressive Oligodeoxynucleotides

Rainald A. Zeuner, Ken J. Ishii, Martin J. Lizak, Ihsan Gursel, Hiroshi Yamada, Dennis M. Klinman, and Daniela Verthelyi

2225

Modulation of Multiple Experimental Arthritis Models by Collagen-Induced Arthritis Quantitative Trait Loci Isolated in Congenic Rat Lines: Different Effects of Non-Major Histocompatibility Complex Quantitative Trait Loci in Males and Females

Elaine F. Remmers, Bina Joe, Marie M. Griffiths, David E. Dobbins, Svetlana V. Dracheva, Akira Hashiramoto, Takefumi Furuya, Jennifer L. Salstrom, JianPing Wang, Percio S. Gulko, Grant W. Cannon, and Ronald L. Wilder

2235

Effect of an Exogenous Trigger on the Pathogenesis of Lupus in (NZB x NZW)F1 Mice

Hideo Yoshida, Minoru Satoh, Krista M. Behney, Chee-Gun Lee, Hanno B. Richards, Victoria M. Shaheen, Jun-Qi Yang, Ram R. Singh, and Westley H. Reeves

2245

Chronic Exertional Compartment Syndrome as a Cause of Bilateral Forearm Pain

S. L. Hider, R. C. Hilton, and C. Hutchinson

2247

Figures Transposed in Article by Tran et al (Arthritis Rheum, June 2002)

2248

2-Chloro-2`-Deoxyadenosine in the Treatment of Sjogren's Syndrome-Associated B Cell Lymphoproliferation

Michalis Voulgarelis, George Petroutsos, Haralampos M. Moutsopoulos, and Fotini N. Skopouli

2249

Treatment With Infliximab Restores Normal Aquaporin 5 Distribution in Minor Salivary Glands of Patients With Sjogren's Syndrome

Serge D. Steinfeld, Thierry Appelboom, and Christine Delporte

2251

Skeletal Muscle Pseudo-Hypertrophy in Myeloma-Associated Amyloidosis

Thomas M. Lawson, Martin A. Bevan, and Bryan D. Williams

2252

Rituximab for the Treatment of Type II Mixed Cryoglobulinemia

Francesco Zaja, Salvatore De Vita, Domenico Russo, Angela Michelutti, Renato Fanin, Gianfranco Ferraccioli, and Michele Baccarani

2254

Reply

Carol A. Langford

2255

Anti-Tumor Necrosis Factor Therapy and Listeria monocytogenes Infection: Report of Two Cases

T. Gluck, H.-J. Linde, J. Scholmerich, U. Muller-Ladner, C. Fiehn, and P. Bohland

2257

Reply

Joel M. Kremer

2257

Bullous Skin Lesions Following Infliximab Infusion in a Patient With Rheumatoid Arthritis

Peter D. Kent, John M. Davis III, Mark D. P. Davis, and Eric L. Matteson

2259

Reply

Ravinder N. Maini and Peter Charles

2259

Synovial Lymphocyte Responses to Microbiologic Antigen Stimulation Indicate the Etiology of Undifferentiated and Reactive Arthritis, and Possibly of Rheumatoid Arthritis: Comment on the Article by Schnarr et al

Denys K. Ford

2260

Reply

Sebastian Schnarr, Michael C. Jendro, Henning Zeidler, and Jens G. Kuipers

2260

Criteria for TUNEL Labeling in Determining Apoptosis in Human Osteoarthritis Cartilage: Comment on the Article by Aigner et al

Juan B. Kouri and Karin Abbud-Lozoya

2262

Parvovirus B19 Infection of Cultured Skin Fibroblasts From Systemic Sclerosis Patients: Comment on the Article by Ray et al

Clodoveo Ferri, Dilia Giuggioli, Marco Sebastiani, Susi Panfilo, Giovanni Abatangelo, Krystyna Zakrzewska, and Alberta Azzi

2263

Reply

Nancy B. Ray, Zhila Khalkhali-Ellis, Daniel R. C. Nieva, Elisabeth A. Seftor, and Stanley J. Naides

2264

Poem

Dan Caspi

21A

Cover image: The figure on the cover (from Glant et al, page 2213) illustrates the histologic features of the knee joint of a transgenic mouse expressing the TSG-6 (tumor necrosis factor-induced protein 6) protein in cartilage. The section was stained with Safranin O to demonstrate sulfated proteoglycans. This system was used to characterize the chondroprotective effect of TSG-6 in an antigen-induced arthritis model.