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Special Articles
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1417
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Review: CD154-CD40
Interactions Mediate Differentiation to Plasma Cells in Healthy Individuals
and Persons With Systemic Lupus Erythematosus
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Amrie C. Grammer
and Peter E. Lipsky
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1430
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Review: Epitope
Spreading in Systemic Lupus Erythematosus: Identification of Triggering
Peptide Sequences
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Fanny Monneaux and
Sylviane Muller
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1439
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Editorial: Vaccination
for Lyme Disease: Cost-Effectiveness Versus Cost and Value
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Leonard H. Sigal
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Rheumatoid
Arthritis
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1443
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Etanercept Versus
Methotrexate in Patients With Early Rheumatoid Arthritis: Two-Year Radiographic
and Clinical Outcomes
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Mark C. Genovese,
Joan M. Bathon, Richard W. Martin, Roy M. Fleischmann, John R. Tesser,
Michael H. Schiff, Edward C. Keystone, Mary Chester Wasko, Larry W.
Moreland, Arthur L. Weaver, Joseph Markenson, Grant W. Cannon, George
Spencer-Green, and Barbara K. Finck
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1451
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The Relationship
of Serum Infliximab Concentrations to Clinical Improvement in Rheumatoid
Arthritis: Results From ATTRACT, a Multicenter, Randomized, Double-Blind,
Placebo-Controlled Trial
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E. William St.Clair,
Carrie L. Wagner, Adedigbo A. Fasanmade, Benjamin Wang, Thomas Schaible,
Arthur Kavanaugh, and Edward C. Keystone
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1460
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Hydroxychloroquine
Concentration-Response Relationships in Patients With Rheumatoid Arthritis
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Tino Munster, John
P. Gibbs, Danny Shen, Bruce A. Baethge, Gary R. Botstein, Jacques Caldwell,
Fredrick Dietz, Robert Ettlinger, Harvey E. Golden, Herbert Lindsley,
George E. McLaughlin, Larry W. Moreland, W. Neal Roberts, Theodore W.
Rooney, Bruce Rothschild, Marshall Sack, Anthony I. Sebba, Michael Weisman,
Kathryn E. Welch, David Yocum, and Daniel E. Furst
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1470
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Costimulatory
Blockade in Patients With Rheumatoid Arthritis: A Pilot, Dose-Finding,
Double-Blind, Placebo-Controlled Clinical Trial Evaluating CTLA-4Ig
and LEA29Y Eighty-Five Days After the First Infusion
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Larry W. Moreland,
Rieke Alten, Filip Van den Bosch, Thierry Appelboom, Marc Leon, Paul
Emery, Stanley Cohen, Michael Luggen, William Shergy, Isaac Nuamah,
and Jean-Claude Becker
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1480
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Heterogeneity
Between Men and Women in the Influence of the HLA-DRB1 Shared Epitope
on the Clinical Expression of Rheumatoid Arthritis
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Inmaculada del Rincon,
Daniel F. Battafarano, Ramon A. Arroyo, Frederick T. Murphy, and Agustin
Escalante
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1489
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Increased Thickness
of the Arterial Intima-Media Detected by Ultrasonography in Patients
With Rheumatoid Arthritis
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Yasuro Kumeda, Masaaki
Inaba, Hitoshi Goto, Mayumi Nagata, Yasuko Henmi, Yutaka Furumitsu,
Eiji Ishimura, Kentaro Inui, Yasutaka Yutani, Takami Miki, Tetsuo Shoji,
and Yoshiki Nishizawa
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1498
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Elevated Levels
of Platelet Microparticles Are Associated With Disease Activity in Rheumatoid
Arthritis
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E. A. J. Knijff-Dutmer,
J. Koerts, R. Nieuwland, E. M. Kalsbeek-Batenburg, and M. A. F. J. van
de Laar
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1504
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Necessary Role
of Phosphatidylinositol 3-Kinase in Transforming Growth Factor [beta]-Mediated
Activation of Akt in Normal and Rheumatoid Arthritis Synovial Fibroblasts
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Giok Kim, Jae-Bum
Jun, and Keith B. Elkon
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1512
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FLICE-Inhibitory
Protein Expression in Synovial Fibroblasts and at Sites of Cartilage
and Bone Erosion in Rheumatoid Arthritis
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Jorg Schedel, Renate
E. Gay, Peter Kuenzler, Christian Seemayer, Beat Simmen, Beat A. Michel,
and Steffen Gay
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Osteoarthritis
and Cartilage
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1519
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Association of
the Interleukin-1 Gene Cluster on Chromosome 2q13 With Knee Osteoarthritis
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John Loughlin, Barbara
Dowling, Zehra Mustafa, and Kay Chapman
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1528
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The [alpha]5[beta]1
Integrin Provides Matrix Survival Signals for Normal and Osteoarthritic
Human Articular Chondrocytes In Vitro
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Judit I. Pulai,
Marcello Del Carlo, Jr., and Richard F. Loeser
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1536
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Regional Quantification
of Cartilage Type II Collagen and Aggrecan Messenger RNA in Joints With
Early Experimental Osteoarthritis
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John Robert Matyas,
Dingqiu Huang, May Chung, and Mark E. Adams
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1544
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Pathologic Indicators
of Degradation and Inflammation in Human Osteoarthritic Cartilage Are
Abrogated by Exposure to n-3 Fatty Acids
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Clare L. Curtis,
Sarah G. Rees, Chris B. Little, Carl R. Flannery, Clare E. Hughes, Chris
Wilson, Colin M. Dent, Ivan G. Otterness, John L. Harwood, and Bruce
Caterson
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Systemic
Lupus Erythematosus and Autoimmunity
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1554
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The Effect of
Anti-CD40 Ligand Antibody on B Cells in Human Systemic Lupus Erythematosus
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Wieqing Huang, Jayashree
Sinha, Jeffrey Newman, Bhoompally Reddy, Lalbachan Budhai, Richard Furie,
Akshay Vaishnaw, and Anne Davidson
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1563
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Role of the Fc[gamma]
Receptor IIa Polymorphism in Susceptibility to Systemic Lupus Erythematosus
and Lupus Nephritis: A Meta-Analysis
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Fotini B. Karassa,
Thomas A. Trikalinos, John P. A. Ioannidis, and the Fc[gamma]RIIa-SLE
Meta-Analysis Investigators
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1572
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Anti-La/SSB Antibodies
Transported Across the Placenta Bind Apoptotic Cells in Fetal Organs
Targeted in Neonatal Lupus
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Hai B. Tran, Peter
J. Macardle, Jenny Hiscock, Dana Cavill, John Bradley, Jill P. Buyon,
and Tom P. Gordon
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1580
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Autologous Blood
Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus
With Severe Pulmonary Impairment: A Case Report
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M. Brunner, H. T.
Greinix, K. Redlich, P. Knobl, J. Smolen, G. Leitner, K. Derfler, W.
Graninger, P. Kalhs, and K. Machold
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Sjogren's
Syndrome
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1585
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Suppression of
Tumor Necrosis Factor [alpha]-Induced Matrix Metalloproteinase 9 Production
in Human Salivary Gland Acinar Cells by Cepharanthine Occurs via Down-Regulation
of Nuclear Factor [Kappa]B: A Possible Therapeutic Agent for Preventing
the Destruction of the Acinar Structure in the Salivary Glands of Sjogren's
Syndrome Patients
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Masayuki Azuma,
Keiko Aota, Tetsuya Tamatani, Katsumi Motegi, Tsuyoshi Yamashita, Yuki
Ashida, Yoshio Hayashi, and Mitsunobu Sato
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Systemic
Sclerosis
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1595
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Antifibroblast
Antibodies From Systemic Sclerosis Patients Are Internalized by Fibroblasts
via a Caveolin-Linked Pathway
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Nicoletta Ronda,
Rita Gatti, Roberto Giacosa, Elena Raschi, Cinzia Testoni, Pier Luigi
Meroni, Carlo Buzio, and Guido Orlandini
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1602
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Autoantibodies
to Fibroblasts Induce a Proadhesive and Proinflammatory Fibroblast Phenotype
in Patients With Systemic Sclerosis
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Carlo Chizzolini,
Elena Raschi, Roger Rezzonico, Cinzia Testoni, Roberto Mallone, Armando
Gabrielli, Andrea Facchini, Nicoletta Del Papa, Maria Orietta Borghi,
Jean Michel Dayer, and Pier Luigi Meroni
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Childhood
Arthritis
|
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1614
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A Gene in the
Telomeric HLA Complex Distinct From HLA-A Is Involved in Predisposition
to Juvenile Idiopathic Arthritis
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|
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Anna Smerdel, Benedicte
A. Lie, Rafal Ploski, Bobby P. C. Koeleman, Oystein F\orre, Erik Thorsby,
and Dag E. Undlien
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1620
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The Efficacy
and Safety of Intraarticular Corticosteroid Therapy for Coxitis in Juvenile
Rheumatoid Arthritis
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|
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Jasper Neidel, Martina
Boehnke, and R. Michael Kuster
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1628
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New Address,
Phone, and Fax Numbers for Arthritis & Rheumatism Editorial Office
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|
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Spondylarthropathy
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1629
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Role of NOD2
Variants in Spondylarthritis
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|
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Alison M. Crane,
Linda Bradbury, David A. van Heel, Dermot P. B. McGovern, Sinead Brophy,
Laurence Rubin, Katherine A. Siminovitch, B. Paul Wordsworth, Andrei
Calin, and Matthew A. Brown
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Vasculitis
|
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1634
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Takayasu Arteritis:
Utility and Limitations of Magnetic Resonance Imaging in Diagnosis and
Treatment
|
|
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Elisa Tso, Scott
D. Flamm, Richard D. White, Paulo R. Schvartzman, Edward Mascha, and
Gary S. Hoffman
|
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|
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Crystal-Induced
Arthropathy
|
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1643
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Monosodium Urate
Monohydrate Crystal-Induced Inflammation In Vivo: Quantitative Histomorphometric
Analysis of Cellular Events
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|
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C. Schiltz, F. Liote,
F. Prudhommeaux, A. Meunier, R. Champy, J. Callebert, and T. Bardin
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|
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|
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Lyme
Disease
|
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1651
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Cost-Effectiveness
Analysis of the Lyme Disease Vaccine
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|
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Elizabeth C. Hsia,
James B. Chung, J. Sanford Schwartz, and Daniel A. Albert
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|
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|
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Animal
Models
|
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1661
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C3-Tat/HIV-Regulated
Intraarticular Human Interleukin-1 Receptor Antagonist Gene Therapy
Results in Efficient Inhibition of Collagen-Induced Arthritis Superior
to Cytomegalovirus-Regulated Expression of the Same Transgene
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|
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A. C. Bakker, F.
A. J. van de Loo, L. A. B. Joosten, O. J. Arntz, A. W. Varley, R. S.
Munford, and W. B. van den Berg
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|
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1671
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Escherichia coli
Heat-Labile Enterotoxin B Subunit Prevents Autoimmune Arthritis Through
Induction of Regulatory CD4+ T Cells
|
|
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Jeffrey A. Luross,
Tricia Heaton, Timothy R. Hirst, Michael J. Day, and Neil A. Williams
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1683
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Fenofibrate Inhibits
Reactive Amyloidosis in Mice
|
|
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Takehiro Murai,
Toshiyuki Yamada, Takashi Miida, Katsumitsu Arai, Naoto Endo, and Tadamasa
Hanyu
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|
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Concise
Communication
|
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1689
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The Role of Intravenous
Immunoglobulin Therapy in Mediating Skin Fibrosis in Tight Skin Mice
|
|
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Miri Blank, Yair
Levy, Howard Amital, Yehuda Shoenfeld, Mark Pines, and Olga Genina
|
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|
|
Erratum
|
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1690
|
Error in Text of
Editorial by Dayer and Bresnihan (Arthritis Rheum, March 2002)
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Letters
|
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1691
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Nephrotic Syndrome
Associated With Anti-Tumor Necrosis Factor [alpha] Therapy in a Patient
With Rheumatoid Arthritis: Comment on the Article by Charles et al
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Alfons A. den Broeder,
Karel J. M. Assmann, Piet L. C. M. van Riel, and Jack F. M. Wetzels
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1693
|
Reply
|
|
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R. N. Maini and
P. Charles
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1693
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Sample Sizes
Estimated in Clinical Trials Using Either a Composite Index (ASAS Response
Criteria) or Single Outcome Variables in Ankylosing Spondylitis
|
|
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Guy-Robert Auleley,
Maxime Dougados, and Gabrial Baron
|
|
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|
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1694
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No Evidence of
an Association Between the Interleukin-10 Promoter GCC Allele and Primary
Sjogren's Syndrome: Comment on the Article by Hulkkonen et al
|
|
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Sue Lester, Vidya
Limaye, Sarah Downie-Doyle, Kevin D. Pile, Peter Bardy, Tom P. Gordon,
and Maureen Rischmueller
|
|
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|
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1696
|
Reply
|
|
|
Janne Hulkkonen,
Marja Pertovaara, Pekka Laippala, Jaakko Antonen, Amos Pasternack, and
Mikko Hurme
|
|
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|
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1697
|
A Chance Meeting
of Two Arthritis Patients
|
|
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Richard D. Sontheimer
|
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|
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Clinical
Images
|
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1698
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Hydroxychloroquine-Associated
Mucocutaneous Hyperpigmentation
|
|
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David G. True, L.
Ray Bryant, Mark D. Harris, and Richard A. Bernert
|
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|
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ACR
Announcements
|
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21A
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Cover image:
The figure on the cover (from Ronda et al, page 1598) shows a confocal
laser scanning micrograph demonstrating the localization of antifibroblast
antibodies in fibroblasts. Antifibroblast antibodies, which occur commonly
in sera of patients with systemic sclerosis, can activate fibroblasts
and may play a role in disease pathogenesis.
|