1417

Review: CD154-CD40 Interactions Mediate Differentiation to Plasma Cells in Healthy Individuals and Persons With Systemic Lupus Erythematosus

Amrie C. Grammer and Peter E. Lipsky

1430

Review: Epitope Spreading in Systemic Lupus Erythematosus: Identification of Triggering Peptide Sequences

Fanny Monneaux and Sylviane Muller

1439

Editorial: Vaccination for Lyme Disease: Cost-Effectiveness Versus Cost and Value

Leonard H. Sigal

1443

Etanercept Versus Methotrexate in Patients With Early Rheumatoid Arthritis: Two-Year Radiographic and Clinical Outcomes

Mark C. Genovese, Joan M. Bathon, Richard W. Martin, Roy M. Fleischmann, John R. Tesser, Michael H. Schiff, Edward C. Keystone, Mary Chester Wasko, Larry W. Moreland, Arthur L. Weaver, Joseph Markenson, Grant W. Cannon, George Spencer-Green, and Barbara K. Finck

1451

The Relationship of Serum Infliximab Concentrations to Clinical Improvement in Rheumatoid Arthritis: Results From ATTRACT, a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

E. William St.Clair, Carrie L. Wagner, Adedigbo A. Fasanmade, Benjamin Wang, Thomas Schaible, Arthur Kavanaugh, and Edward C. Keystone

1460

Hydroxychloroquine Concentration-Response Relationships in Patients With Rheumatoid Arthritis

Tino Munster, John P. Gibbs, Danny Shen, Bruce A. Baethge, Gary R. Botstein, Jacques Caldwell, Fredrick Dietz, Robert Ettlinger, Harvey E. Golden, Herbert Lindsley, George E. McLaughlin, Larry W. Moreland, W. Neal Roberts, Theodore W. Rooney, Bruce Rothschild, Marshall Sack, Anthony I. Sebba, Michael Weisman, Kathryn E. Welch, David Yocum, and Daniel E. Furst

1470

Costimulatory Blockade in Patients With Rheumatoid Arthritis: A Pilot, Dose-Finding, Double-Blind, Placebo-Controlled Clinical Trial Evaluating CTLA-4Ig and LEA29Y Eighty-Five Days After the First Infusion

Larry W. Moreland, Rieke Alten, Filip Van den Bosch, Thierry Appelboom, Marc Leon, Paul Emery, Stanley Cohen, Michael Luggen, William Shergy, Isaac Nuamah, and Jean-Claude Becker

1480

Heterogeneity Between Men and Women in the Influence of the HLA-DRB1 Shared Epitope on the Clinical Expression of Rheumatoid Arthritis

Inmaculada del Rincon, Daniel F. Battafarano, Ramon A. Arroyo, Frederick T. Murphy, and Agustin Escalante

1489

Increased Thickness of the Arterial Intima-Media Detected by Ultrasonography in Patients With Rheumatoid Arthritis

Yasuro Kumeda, Masaaki Inaba, Hitoshi Goto, Mayumi Nagata, Yasuko Henmi, Yutaka Furumitsu, Eiji Ishimura, Kentaro Inui, Yasutaka Yutani, Takami Miki, Tetsuo Shoji, and Yoshiki Nishizawa

1498

Elevated Levels of Platelet Microparticles Are Associated With Disease Activity in Rheumatoid Arthritis

E. A. J. Knijff-Dutmer, J. Koerts, R. Nieuwland, E. M. Kalsbeek-Batenburg, and M. A. F. J. van de Laar

1504

Necessary Role of Phosphatidylinositol 3-Kinase in Transforming Growth Factor [beta]-Mediated Activation of Akt in Normal and Rheumatoid Arthritis Synovial Fibroblasts

Giok Kim, Jae-Bum Jun, and Keith B. Elkon

1512

FLICE-Inhibitory Protein Expression in Synovial Fibroblasts and at Sites of Cartilage and Bone Erosion in Rheumatoid Arthritis

Jorg Schedel, Renate E. Gay, Peter Kuenzler, Christian Seemayer, Beat Simmen, Beat A. Michel, and Steffen Gay

1519

Association of the Interleukin-1 Gene Cluster on Chromosome 2q13 With Knee Osteoarthritis

John Loughlin, Barbara Dowling, Zehra Mustafa, and Kay Chapman

1528

The [alpha]5[beta]1 Integrin Provides Matrix Survival Signals for Normal and Osteoarthritic Human Articular Chondrocytes In Vitro

Judit I. Pulai, Marcello Del Carlo, Jr., and Richard F. Loeser

1536

Regional Quantification of Cartilage Type II Collagen and Aggrecan Messenger RNA in Joints With Early Experimental Osteoarthritis

John Robert Matyas, Dingqiu Huang, May Chung, and Mark E. Adams

1544

Pathologic Indicators of Degradation and Inflammation in Human Osteoarthritic Cartilage Are Abrogated by Exposure to n-3 Fatty Acids

Clare L. Curtis, Sarah G. Rees, Chris B. Little, Carl R. Flannery, Clare E. Hughes, Chris Wilson, Colin M. Dent, Ivan G. Otterness, John L. Harwood, and Bruce Caterson

1554

The Effect of Anti-CD40 Ligand Antibody on B Cells in Human Systemic Lupus Erythematosus

Wieqing Huang, Jayashree Sinha, Jeffrey Newman, Bhoompally Reddy, Lalbachan Budhai, Richard Furie, Akshay Vaishnaw, and Anne Davidson

1563

Role of the Fc[gamma] Receptor IIa Polymorphism in Susceptibility to Systemic Lupus Erythematosus and Lupus Nephritis: A Meta-Analysis

Fotini B. Karassa, Thomas A. Trikalinos, John P. A. Ioannidis, and the Fc[gamma]RIIa-SLE Meta-Analysis Investigators

1572

Anti-La/SSB Antibodies Transported Across the Placenta Bind Apoptotic Cells in Fetal Organs Targeted in Neonatal Lupus

Hai B. Tran, Peter J. Macardle, Jenny Hiscock, Dana Cavill, John Bradley, Jill P. Buyon, and Tom P. Gordon

1580

Autologous Blood Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus With Severe Pulmonary Impairment: A Case Report

M. Brunner, H. T. Greinix, K. Redlich, P. Knobl, J. Smolen, G. Leitner, K. Derfler, W. Graninger, P. Kalhs, and K. Machold

1585

Suppression of Tumor Necrosis Factor [alpha]-Induced Matrix Metalloproteinase 9 Production in Human Salivary Gland Acinar Cells by Cepharanthine Occurs via Down-Regulation of Nuclear Factor [Kappa]B: A Possible Therapeutic Agent for Preventing the Destruction of the Acinar Structure in the Salivary Glands of Sjogren's Syndrome Patients

Masayuki Azuma, Keiko Aota, Tetsuya Tamatani, Katsumi Motegi, Tsuyoshi Yamashita, Yuki Ashida, Yoshio Hayashi, and Mitsunobu Sato

1595

Antifibroblast Antibodies From Systemic Sclerosis Patients Are Internalized by Fibroblasts via a Caveolin-Linked Pathway

Nicoletta Ronda, Rita Gatti, Roberto Giacosa, Elena Raschi, Cinzia Testoni, Pier Luigi Meroni, Carlo Buzio, and Guido Orlandini

1602

Autoantibodies to Fibroblasts Induce a Proadhesive and Proinflammatory Fibroblast Phenotype in Patients With Systemic Sclerosis

Carlo Chizzolini, Elena Raschi, Roger Rezzonico, Cinzia Testoni, Roberto Mallone, Armando Gabrielli, Andrea Facchini, Nicoletta Del Papa, Maria Orietta Borghi, Jean Michel Dayer, and Pier Luigi Meroni

1614

A Gene in the Telomeric HLA Complex Distinct From HLA-A Is Involved in Predisposition to Juvenile Idiopathic Arthritis

Anna Smerdel, Benedicte A. Lie, Rafal Ploski, Bobby P. C. Koeleman, Oystein F\orre, Erik Thorsby, and Dag E. Undlien

1620

The Efficacy and Safety of Intraarticular Corticosteroid Therapy for Coxitis in Juvenile Rheumatoid Arthritis

Jasper Neidel, Martina Boehnke, and R. Michael Kuster

1628

New Address, Phone, and Fax Numbers for Arthritis & Rheumatism Editorial Office

1629

Role of NOD2 Variants in Spondylarthritis

Alison M. Crane, Linda Bradbury, David A. van Heel, Dermot P. B. McGovern, Sinead Brophy, Laurence Rubin, Katherine A. Siminovitch, B. Paul Wordsworth, Andrei Calin, and Matthew A. Brown

1634

Takayasu Arteritis: Utility and Limitations of Magnetic Resonance Imaging in Diagnosis and Treatment

Elisa Tso, Scott D. Flamm, Richard D. White, Paulo R. Schvartzman, Edward Mascha, and Gary S. Hoffman

1643

Monosodium Urate Monohydrate Crystal-Induced Inflammation In Vivo: Quantitative Histomorphometric Analysis of Cellular Events

C. Schiltz, F. Liote, F. Prudhommeaux, A. Meunier, R. Champy, J. Callebert, and T. Bardin

1651

Cost-Effectiveness Analysis of the Lyme Disease Vaccine

Elizabeth C. Hsia, James B. Chung, J. Sanford Schwartz, and Daniel A. Albert

1661

C3-Tat/HIV-Regulated Intraarticular Human Interleukin-1 Receptor Antagonist Gene Therapy Results in Efficient Inhibition of Collagen-Induced Arthritis Superior to Cytomegalovirus-Regulated Expression of the Same Transgene

A. C. Bakker, F. A. J. van de Loo, L. A. B. Joosten, O. J. Arntz, A. W. Varley, R. S. Munford, and W. B. van den Berg

1671

Escherichia coli Heat-Labile Enterotoxin B Subunit Prevents Autoimmune Arthritis Through Induction of Regulatory CD4+ T Cells

Jeffrey A. Luross, Tricia Heaton, Timothy R. Hirst, Michael J. Day, and Neil A. Williams

1683

Fenofibrate Inhibits Reactive Amyloidosis in Mice

Takehiro Murai, Toshiyuki Yamada, Takashi Miida, Katsumitsu Arai, Naoto Endo, and Tadamasa Hanyu

1689

The Role of Intravenous Immunoglobulin Therapy in Mediating Skin Fibrosis in Tight Skin Mice

Miri Blank, Yair Levy, Howard Amital, Yehuda Shoenfeld, Mark Pines, and Olga Genina

1690

Error in Text of Editorial by Dayer and Bresnihan (Arthritis Rheum, March 2002)

1691

Nephrotic Syndrome Associated With Anti-Tumor Necrosis Factor [alpha] Therapy in a Patient With Rheumatoid Arthritis: Comment on the Article by Charles et al

Alfons A. den Broeder, Karel J. M. Assmann, Piet L. C. M. van Riel, and Jack F. M. Wetzels

1693

Reply

R. N. Maini and P. Charles

1693

Sample Sizes Estimated in Clinical Trials Using Either a Composite Index (ASAS Response Criteria) or Single Outcome Variables in Ankylosing Spondylitis

Guy-Robert Auleley, Maxime Dougados, and Gabrial Baron

1694

No Evidence of an Association Between the Interleukin-10 Promoter GCC Allele and Primary Sjogren's Syndrome: Comment on the Article by Hulkkonen et al

Sue Lester, Vidya Limaye, Sarah Downie-Doyle, Kevin D. Pile, Peter Bardy, Tom P. Gordon, and Maureen Rischmueller

1696

Reply

Janne Hulkkonen, Marja Pertovaara, Pekka Laippala, Jaakko Antonen, Amos Pasternack, and Mikko Hurme

1697

A Chance Meeting of Two Arthritis Patients

Richard D. Sontheimer

1698

Hydroxychloroquine-Associated Mucocutaneous Hyperpigmentation

David G. True, L. Ray Bryant, Mark D. Harris, and Richard A. Bernert

21A

Cover image: The figure on the cover (from Ronda et al, page 1598) shows a confocal laser scanning micrograph demonstrating the localization of antifibroblast antibodies in fibroblasts. Antifibroblast antibodies, which occur commonly in sera of patients with systemic sclerosis, can activate fibroblasts and may play a role in disease pathogenesis.