567

ACR Presidential Address: The Best of Times, the Worst of Times: Rheumatology 2001

Michael E. Weinblatt

574

Editorial: Targeting Interleukin-1 in the Treatment of Rheumatoid Arthritis

Jean-Michel Dayer and Barry Bresnihan

579

Editorial: The Changing Face of Rheumatoid Arthritis: Why the Decline in Incidence?

Alan J. Silman

582

Editorial: The Search for Rheumatoid Arthritis Susceptibility Genes: A Call for Global Collaboration

Damini Jawaheer and Peter K. Gregersen

585

Review: Hepatitis C Virus Infection and Vasculitis: Implications of Antiviral and Immunosuppressive Therapies

Dimitrios Vassilopoulos and Leonard H. Calabrese

598

Review: Peroxisome Proliferator-Activated Receptor [gamma] Agonists: Potential Use for Treating Chronic Inflammatory Diseases

James C. Oates, Christopher M. Reilly, Michelle B. Crosby, and Gary S. Gilkeson

606

Conference Summary: The Cutting Edge of Spondylarthropathy Research in the Millennium

Kaisa Granfors, Elisabeth Marker-Hermann, Filip de Keyser, Muhammad A. Khan, Eric M. Veys, and David T. Y. Yu

614

Treatment of Rheumatoid Arthritis With Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, in Combination With Methotrexate: Results of a Twenty-Four-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Stanley Cohen, Eric Hurd, John Cush, Michael Schiff, Michael E. Weinblatt, Larry W. Moreland, Joel Kremer, Moraye B. Bear, William J. Rich, and Dorothy McCabe

625

Trends in Incidence and Mortality in Rheumatoid Arthritis in Rochester, Minnesota, Over a Forty-Year Period

Michele F. Doran, Gregory R. Pond, Cynthia S. Crowson, W. Michael O'Fallon, and Sherine E. Gabriel

632

Whole-Genome Linkage Analysis of Rheumatoid Arthritis Susceptibility Loci in 252 Affected Sibling Pairs in the United Kingdom

Kirsten MacKay, Stephen Eyre, Anne Myerscough, Anita Milicic, Anne Barton, Steven Laval, Jenny Barrett, Dorothea Lee, Sarah White, Sally John, Matthew A. Brown, John Bell, Alan Silman, William Ollier, Paul Wordsworth, and Jane Worthington

640

Smoking and Disease Severity in Rheumatoid Arthritis: Association With Polymorphism at the Glutathione S-Transferase M1 Locus

Derek L. Mattey, David Hutchinson, Peter T. Dawes, Nicola B. Nixon, Sheila Clarke, June Fisher, Ann Brownfield, Julie Alldersea, Anthony A. Fryer, and Richard C. Strange

647

The Value of Contrast-Enhanced Color Doppler Ultrasound in the Detection of Vascularization of Finger Joints in Patients With Rheumatoid Arthritis

Andrea Klauser, Ferdinand Frauscher, Michael Schirmer, Ethan Halpern, Leo Pallwein, Manfred Herold, Gernot Helweg, and Dieter ZurNedden

654

Inadequately Low Serum Levels of Steroid Hormones in Relation to Interleukin-6 and Tumor Necrosis Factor in Untreated Patients With Early Rheumatoid Arthritis and Reactive Arthritis

Rainer H. Straub, Leena Paimela, Ritva Peltomaa, Jurgen Scholmerich, and Marjatta Leirisalo-Repo

663

Comparison of Cathepsins K and S Expression Within the Rheumatoid and Osteoarthritic Synovium

Wu-Shiun Hou, Weijie Li, Gernot Keyszer, Ekkehard Weber, Roger Levy, Michael J. Klein, Ellen M. Gravallese, Steven R. Goldring, and Dieter Bromme

675

Risk Factors for Total Hip Replacement Due to Primary Osteoarthritis: A Cohort Study in 50,034 Persons

Gunnar B. Flugsrud, Lars Nordsletten, Birgitte Espehaug, Leif I. Havelin, and Haakon E. Meyer

683

Increased Life Span of Human Osteoarthritic Chondrocytes by Exogenous Expression of Telomerase

Sonsoles Piera-Velazquez, Sergio A. Jimenez, and David G. Stokes

694

Inhibition of Insulin-Like Growth Factor Binding Protein 5 Proteolysis in Articular Cartilage and Joint Fluid Results in Enhanced Concentrations of Insulin-Like Growth Factor 1 and Is Associated With Improved Osteoarthritis

David R. Clemmons, Walker H. Busby, Jr., Aaron Garmong, Duane R. Schultz, David S. Howell, Roy D. Altman, and Robert Karr

704

Reduced Chondrogenic and Adipogenic Activity of Mesenchymal Stem Cells From Patients With Advanced Osteoarthritis

J. Mary Murphy, Kenneth Dixon, Stephen Beck, Dennis Fabian, Andrew Feldman, and Frank Barry

714

The PedsQL[trade mark] in Pediatric Rheumatology: Reliability, Validity, and Responsiveness of the Pediatric Quality of Life Inventory[trade mark] Generic Core Scales and Rheumatology Module

James W. Varni, Michael Seid, Tara Smith Knight, Tasha Burwinkle, Joy Brown, and Ilona S. Szer

726

Autoantibody to hLSm4 and the Heptameric LSm Complex in Anti-Sm Sera

Theophany Eystathioy, Carol L. Peebles, John C. Hamel, John H. Vaughan, and Edward K. L. Chan

735

Selective Accumulation of CCR4+ T Lymphocytes Into Renal Tissue of Patients With Lupus Nephritis

Masato Yamada, Hideo Yagita, Hideko Inoue, Tsuyoshi Takanashi, Hironori Matsuda, Eiko Munechika, Yutaka Kanamaru, Isao Shirato, Yasuhiko Tomino, Kouji Matushima, Ko Okumura, and Hiroshi Hashimoto

741

Long-Term Risk of Mortality and Lymphoproliferative Disease and Predictive Classification of Primary Sjogren's Syndrome

John P. A. Ioannidis, Vassilios A. Vassiliou, and Haralampos M. Moutsopoulos

748

A Double-Blind, Randomized, Placebo-Controlled Study of Cevimeline in Sjogren's Syndrome Patients With Xerostomia and Keratoconjunctivitis Sicca

Dianne Petrone, John J. Condemi, Rose Fife, Oscar Gluck, Stanley Cohen, and Paul Dalgin

755

Randomized Double-Blind Comparison of Chimeric Monoclonal Antibody to Tumor Necrosis Factor [alpha] (Infliximab) Versus Placebo in Active Spondylarthropathy

Filip Van den Bosch, Elli Kruithof, Dominique Baeten, Annemie Herssens, Filip de Keyser, Herman Mielants, and Eric M. Veys

766

A Six-Month Randomized, Controlled, Double-Blind, Dose-Response Comparison of Intravenous Pamidronate (60 mg Versus 10 mg) in the Treatment of Nonsteroidal Antiinflammatory Drug-Refractory Ankylosing Spondylitis

Walter P. Maksymowych, Gian S. Jhangri, Avril A. Fitzgerald, Sharon LeClercq, Peter Chiu, Alex Yan, Kenneth J. Skeith, Stephen L. Aaron, Joanne Homik, Paul Davis, Dale Sholter, and Anthony S. Russell

774

Investigation of Fluoroquinolone-Induced Myalgia Using 31P Magnetic Resonance Spectroscopy and In Vitro Contracture Tests

S. Guis, D. Bendahan, G. Kozak-Ribbens, J. P. Mattei, Y. Le Fur, S. Confort-Gouny, D. Figarella-Branger, J. Jouglard, and P. J. Cozzone

779

Secular Changes in the Quality of Published Randomized Clinical Trials in Rheumatology

Catherine L. Hill, Michael P. LaValley, and David T. Felson

785

Tumor Necrosis Factor [alpha]-Mediated Joint Destruction Is Inhibited by Targeting Osteoclasts With Osteoprotegerin

Kurt Redlich, Silvia Hayer, Andrea Maier, Colin R. Dunstan, Makiyeh Tohidast-Akrad, Susanne Lang, Birgit Turk, Peter Pietschmann, Wolfgang Woloszczuk, Silva Haralambous, George Kollias, Gunter Steiner, Josef S. Smolen, and Georg Schett

793

Angiostatin Gene Transfer as an Effective Treatment Strategy in Murine Collagen-Induced Arthritis

Jong-Mook Kim, Seong-Hyun Ho, Eun-Jin Park, Woong Hahn, Hongchan Cho, Jae-Gyun Jeong, Yun-Woo Lee, and Sunyoung Kim

802

Reduction of Joint Inflammation and Bone Erosion in Rat Adjuvant Arthritis by Treatment With Interleukin-17 Receptor IgG1 Fc Fusion Protein

Katherine A. Bush, Katherine M. Farmer, Judith S. Walker, and Bruce W. Kirkham

806

The Beneficial Effect of Interleukin-12 on Arthritis Induced by Group B Streptococci Is Mediated by Interferon-[gamma] and Interleukin-10 Production

Manuela Puliti, Christina von Hunolstein, Francesco Bistoni, Paolo Mosci, Graziella Orefici, and Luciana Tissi

818

Joint Damage and Inflammation in c-Jun N-Terminal Kinase 2 Knockout Mice With Passive Murine Collagen-Induced Arthritis

Zuoning Han, Lufen Chang, Yuji Yamanishi, Michael Karin, and Gary S. Firestein

824

Stromal Cell-Derived Factor 1 (CXCL12) Induces Monocyte Migration Into Human Synovium Transplanted Onto SCID Mice

M. C. Blades, F. Ingegnoli, S. K. Wheller, A. Manzo, S. Wahid, G. S. Panayi, M. Perretti, and C. Pitzalis

837

High-Dose Cyclophosphamide With Stem Cell Rescue for Severe Rheumatoid Arthritis: Short-Term Efficacy Correlates With Reduction of Macroscopic and Histologic Synovitis

Sarah Bingham, Douglas Veale, Ursula Fearon, John D. Isaacs, Gareth Morgan, Paul Emery, Dennis McGonagle, Richard Reece, Roy Clague, and John A. Snowden

840

Refractory Inflammatory Heel Pain in Spondylarthropathy: A Significant Response to Infliximab Documented by Ultrasound

Maria Antonietta D'Agostino, Maxime Breban, Roula Said-Nahal, and Maxime Dougados

841

Reply

Juergen Braun and Joachim Sieper

843

Development of Rheumatoid Nodules During Anti-Tumor Necrosis Factor [alpha] Therapy With Etanercept

Jorn Kekow, Tobias Welte, Udo Kellner, and Thomas Pap

844

Topotecan and the Development of Scleroderma or a Scleroderma-Like Illness

Daniel Ene-Stroescu, Michael H. Ellman, and Carol E. Peterson

845

Methotrexate for the Treatment of Early Diffuse Scleroderma: Comment on the Article by Pope et al

Thomas J. A. Lehman

845

Confirmation of an Association Between Fibromyalgia and Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism, and Relationship to Anxiety-Related Personality Traits

Hagit Cohen, Dan Buskila, Lily Neumann, and Richard P. Ebstein

847

Effect of Intraarticular Hyaluronate Injections in Chondrocalcinosis: Comment on the Article by Martens

Montserrat Romera

847

Reply

Peter B. Martens

847

Inflammatory Arthritis and the Diagnosis and Management of Iron Deficiency: Comment on the Article by Bultink et al

R. L. Neame, M. Auger, and D. A. Walsh

848

Reply

Irene E. M. Bultink, Willem F. Lems, Rob J. van de Stadt, and Ben A. C. Dijkmans

849

Absence of Anti-Cyclic Citrullinated Peptide Antibodies in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Jan Willem Cohen Tervaert, Jan Damoiseaux, Maarten M. Boomsma, and Coen A. Stegeman

850

Catastrophic Antiphospholipid Syndrome Associated With Typhoid Fever: Comment on the Article by Hayem et al

Imad Uthman, Ali Taher, Ismail Khalil, Abdul-Rahman Bizri, and Azzudin E. Gharavi

21A

Cover image: The figure on the cover (from Murphy et al, page 711) illustrates the histologic analysis of mesenchymal stem cells from patients with osteoarthritis, with oil red O staining used to assess adipogenic potential. Mesenchymal stem cells are present in the bone marrow and can differentiate along a number of connective tissue pathways. Assessment of chondrogenic or adipogenic potential of these cells provides an important in vitro measure of their functional capacity.