1

Editorial: Osteoarthritis, Bone Mass, and Fractures: How Are They Related?

Nancy E. Lane and Michael C. Nevitt

5

Review: HLA Class II Tetramers: Tools for Direct Analysis of Antigen-Specific CD4+ T Cells

Gerald T. Nepom, Jane H. Buckner, Erik J. Novak, Sandra Reichstetter, Helena Reijonen, John Gebe, Rongfang Wang, Eric Swanson, and William W. Kwok

13

Review: Matrix Metalloproteinases as Therapeutic Targets in Arthritic Diseases: Bull's-Eye or Missing the Mark?

John A. Mengshol, Kimberlee S. Mix, and Constance E. Brinckerhoff

21

Association of Baseline Levels of Urinary Glucosyl-Galactosyl-Pyridinoline and Type II Collagen C-Telopeptide With Progression of Joint Destruction in Patients With Early Rheumatoid Arthritis

Patrick Garnero, Evelyne Gineyts, Stephan Christgau, Barbara Finck, and Pierre D. Delmas

31

Evidence That Rheumatoid Arthritis Synovial T Cells Are Similar to Cytokine-Activated T Cells: Involvement of Phosphatidylinositol 3-Kinase and Nuclear Factor [Kappa]B Pathways in Tumor Necrosis Factor [alpha] Production in Rheumatoid Arthritis

Fionula M. Brennan, Amanda L. Hayes, Cathleen J. Ciesielski, Patricia Green, Brian M. J. Foxwell, and Marc Feldmann

42

Cyclosporine Differentially Regulates Interleukin-10, Interleukin-15, and Tumor Necrosis Factor [alpha] Production by Rheumatoid Synoviocytes

Mi-La Cho, Wan-Uk Kim, So-Youn Min, Do-June Min, Jun-Ki Min, Sang-Heon Lee, Sung-Hwan Park, Chul-Soo Cho, and Ho-Youn Kim

52

Identification of Differentially Expressed Genes in Rheumatoid Arthritis by a Combination of Complementary DNA Array and RNA Arbitrarily Primed-Polymerase Chain Reaction

E. Neumann, F. Kullmann, M. Judex, H. P. Justen, D. Wessinghage, S. Gay, J. Scholmerich, and U. Muller-Ladner

64

Stimulation of Collagenase 3 Expression in Synovial Fibroblasts of Patients With Rheumatoid Arthritis by Contact With a Three-Dimensional Collagen Matrix or With Normal Cartilage When Coimplanted in NOD/SCID Mice

Dirk Wernicke, Claudia Schulze-Westhoff, Peter Petrow, Rolf Brauer, Josef Zacher, Steffen Gay, and Erika Gromnica-Ihle

75

Association of Familial and Sporadic Rheumatoid Arthritis With a Single Corticotropin-Releasing Hormone Genomic Region (8q12.3) Haplotype

Mark Fife, Sophia Steer, Sheila Fisher, Julia Newton, Kirsten McKay, Jane Worthington, Chandrabala Shah, Andreas Polley, Andre Rosenthal, William Ollier, Cathryn Lewis, Paul Wordsworth, and Jerry Lanchbury

83

Coffee, Tea, and Caffeine Consumption and Risk of Rheumatoid Arthritis: Results From the Iowa Women's Health Study

Ted R. Mikuls, James R. Cerhan, Lindsey A. Criswell, Linda Merlino, Amy S. Mudano, Molly Burma, Aaron R. Folsom, and Kenneth G. Saag

92

The Relationship of Bone Density and Fracture to Incident and Progressive Radiographic Osteoarthritis of the Knee: The Chingford Study

Deborah J. Hart, Camille Cronin, Maxine Daniels, Tina Worthy, David V. Doyle, and Tim D. Spector

100

Tidal Irrigation as Treatment for Knee Osteoarthritis: A Sham-Controlled, Randomized, Double-Blinded Evaluation

John D. Bradley, Douglas K. Heilman, Barry P. Katz, Patricia G'Sell, Janine E. Wallick, and Kenneth D. Brandt

109

Field Test of the Reproducibility of the Semiflexed Metatarsophalangeal View in Repeated Radiographic Examinations of Subjects With Osteoarthritis of the Knee

Steven A. Mazzuca, Kenneth D. Brandt, Kenneth A. Buckwalter, Kathleen A. Lane, and Barry P. Katz

114

Crosslinking by Advanced Glycation End Products Increases the Stiffness of the Collagen Network in Human Articular Cartilage: A Possible Mechanism Through Which Age Is a Risk Factor for Osteoarthritis

Nicole Verzijl, Jeroen DeGroot, Chaya Ben Zaken, Orit Braun-Benjamin, Alice Maroudas, Ruud A. Bank, Joe Mizrahi, Casper G. Schalkwijk, Suzanne R. Thorpe, John W. Baynes, Johannes W. J. Bijlsma, Floris P. J. G. Lafeber, and Johan M. TeKoppele

124

Cyclosporin A Inhibition of Aggrecanase-Mediated Proteoglycan Catabolism in Articular Cartilage

Chris B. Little, Clare E. Hughes, Clare L. Curtis, Simon A. Jones, Bruce Caterson, and Carl R. Flannery

130

Stimulation of Matrix Metalloprotease 3 Release From Human Chondrocytes by the Interaction of Stromal Cell-Derived Factor 1 and CXC Chemokine Receptor 4

Katsuaki Kanbe, Kenji Takagishi, and Qian Chen

138

A Fibronectin Fragment Induces Type II Collagen Degradation by Collagenase Through an Interleukin-1-Mediated Pathway

Tadashi Yasuda and A. Robin Poole

149

Bone Morphogenetic Proteins Promote Cartilage Differentiation and Protect Engineered Artificial Cartilage From Fibroblast Invasion and Destruction

Christian Kaps, Carsten Bramlage, Heike Smolian, Andreas Haisch, Ute Ungethum, Gerd-R. Burmester, Michael Sittinger, Gerhard Gross, and Thomas Haupl

163

Abnormal Expression of Various Molecular Forms and Distribution of T Cell Receptor [zeta] Chain in Patients With Systemic Lupus Erythematosus

Madhusoodana P. Nambiar, Edith J. Enyedy, Carolyn U. Fisher, Sandeep Krishnan, Vishal G. Warke, William R. Gilliland, Robert J. Oglesby, and George C. Tsokos

175

Mitochondrial Hyperpolarization and ATP Depletion in Patients With Systemic Lupus Erythematosus

Peter Gergely, Jr., Craig Grossman, Brian Niland, Ferenc Puskas, Hom Neupane, Fatme Allam, Katalin Banki, Paul E. Phillips, and Andras Perl

191

Impaired Uptake of Apoptotic Cells Into Tingible Body Macrophages in Germinal Centers of Patients With Systemic Lupus Erythematosus

Irith Baumann, Wasilis Kolowos, Reinhard E. Voll, Bernhard Manger, Udo Gaipl, Winfried L. Neuhuber, Thomas Kirchner, Joachim R. Kalden, and Martin Herrmann

202

Subcellular Redistribution of La/SSB Autoantigen During Physiologic Apoptosis in the Fetal Mouse Heart and Conduction System: A Clue to the Pathogenesis of Congenital Heart Block

Hai B. Tran, Maria Ohlsson, Dimitra Beroukas, Jenny Hiscock, John Bradley, Jill P. Buyon, and Tom P. Gordon

209

Candidate T Cell Epitopes of the Human La/SSB Autoantigen

Marie L. Davies, Emma J. Taylor, Caroline Gordon, Stephen P. Young, Ken Welsh, Mike Bunce, B. Paul Wordsworth, Brian Davidson, and Simon J. Bowman

215

Characterization of the Cysteine-Rich Secretory Protein 3 Gene as an Early-Transcribed Gene With a Putative Role in the Pathophysiology of Sjogren's Syndrome

Nikolaos I. Tapinos, Mary Polihronis, George Thyphronitis, and Haralampos M. Moutsopoulos

223

Functional Disability Predicts Total Costs in Patients With Ankylosing Spondylitis

Michael M. Ward

232

Macrophage Migration Inhibitory Factor in Patients With Juvenile Idiopathic Arthritis

Cristina Meazza, Paola Travaglino, Patrizia Pignatti, Silvia Magni-Manzoni, Angelo Ravelli, Alberto Martini, and Fabrizio De Benedetti

238

Identification of Type II Collagen Peptide 261-273-Specific T Cell Clones in a Patient With Relapsing Polychondritis

Jane H. Buckner, Megan Van Landeghen, William W. Kwok, and Laura Tsarknaridis

245

An Israeli Arab Patient With a De Novo TNFRSF1A Mutation Causing Tumor Necrosis Factor Receptor-Associated Periodic Syndrome

Ebun Aganna, Avraham Zeharia, Graham A. Hitman, Lina Basel-Vanagaite, Rebecca A. Allotey, David R. Booth, Philip N. Hawkins, Catherine Thacker, Denise Syndercombe-Court, and Michael F. McDermott

250

Sexual Dimorphism in Innate Immunity

George Moxley, Danielle Posthuma, Patricia Carlson, Eloise Estrada, Jinfeng Han, Linda L. Benson, and Michael C. Neale

259

Genetic Links Between the Acute-Phase Response and Arthritis Development in Rats

Peter Olofsson, Niklas Nordquist, Carina Vingsbo-Lundberg, Anders Larsson, Cecilia Falkenberg, Ulf Pettersson, Bo Akerstrom, and Rikard Holmdahl

269

The Presence of IgG Antibodies Reactive With Components of the SSA/Ro-SSB/La Complex in Human Breast Milk: Implications in Neonatal Lupus

Anca D. Askanase, M. Eugenia Miranda-Carus, Xiaoyin Tang, Margaret Katholi, and Jill P. Buyon

271

Therapeutic Effect of Vasoactive Intestinal Peptide in Collagen-Induced Arthritis

Richard O. Williams

274

Effect of Dynamic Strength Training on Functional Capacity in Rheumatoid Arthritis: Comment on the Article by Hakkinen et al

Marten Munneke, Zuzana de Jong, Aeilko H. Zwinderman, Theodora P. M. Vliet Vlieland, and Johanna M. W. Hazes

274

Reply

Arja Hakkinen, Tuulikki Sokka, Pekka Hannonen, and Antero Kotaniemi

276

Absence of Anti-p53 Antibodies in Chinese Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus: Comment on the Concise Communication by Kovacs et al

Ming-Yuh Shiau, Tzer-Min Kuo, Gregory J. Tsay, Hui-Ling Chiou, Yao-Ling Lee, and Yih-Hsin Chang

276

Reply

Birgit Kovacs and George C. Tsokos

277

Onset of Rheumatoid Arthritis Following Curative Treatment of a Somatostatinoma

A. Grasland, J. Pouchot, P. Vinceneux, and P. Ruszniewski

278

Clinical and Prognostic Value of Antineutrophil Cytoplasmic Antibodies in Wegener's Granulomatosis and Microscopic Polyangiitis: Comment on the Article by Russell et al

Branka Bonaci-Nikolic, Sladjana Andrejevic, Mirjana Bukilica, and Milos M. Nikolic

279

Reply

Kimberly A. Russell, David N. Fass, and Ulrich Specks

280

Failure to Detect Antinucleosome Antibodies in Scleroderma: Comment on the Article by Amoura et al

Youssef Ben Hadj Hmida, Patrick Schmit, Georges Gilson, and Rene-Louis Humbel

281

Reply

Zahir Amoura, Lucile Musset, and Jean-Charles Piette

282

Erratum

Error in Spelling of Author's Name in Second-Year Fellow Abstract SY-09 (Arthritis Rheum, December 2001)

19A

Cover image: The figure on the cover (from Nepom et al, page 6) depicts a model of an HLA class II tetramer. MHC [alpha] and [beta] chains are extended with flexible linker sequences and leucine zippers (helices), and each [beta] chain further extends with a biotinylated sequence to a central streptavidin tetramer. Antigenic peptides presented by the MHC are shown as spheres.