2707

Editorial: Nails in the Coffin: Increasing Evidence for the Role of Rheumatic Disease in the Cardiovascular Mortality of Rheumatoid Arthritis

P. A. Bacon and J. N. Townend

2711

Editorial: Examining Health Disparities in Systemic Lupus Erythematosus

Michael M. Ward

2715

Review: Immunoglobulin Variable-Region Gene Usage in Systemic Autoimmune Diseases

Thomas Dorner and Peter E. Lipsky

2728

Review: Inflammatory Bowel Disease and Spondylarthropathy

Simon Smale, Ravinder S. Natt, Timothy R. Orchard, Anthony S. Russell, and Ingvar Bjarnason

2737

High Incidence of Cardiovascular Events in a Rheumatoid Arthritis Cohort Not Explained by Traditional Cardiac Risk Factors

Inmaculada del Rincon, Ken Williams, Michael P. Stern, Gregory L. Freeman, and Agustin Escalante

2746

Long-Term Morbidity, Mortality, and Economics of Rheumatoid Arthritis

John B. Wong, Dena R. Ramey, and Gurkirpal Singh

2750

Selective Lymphocyte Chemokine Receptor Expression in the Rheumatoid Joint

Jeffrey H. Ruth, James B. Rottman, Kenneth J. Katschke, Jr., Shixin Qin, Lijun Wu, Gregory LaRosa, Paul Ponath, Richard M. Pope, and Alisa E. Koch

2761

Elevated Levels of Small, Low-Density Lipoprotein With High Affinity for Arterial Matrix Components in Patients With Rheumatoid Arthritis: Possible Contribution of Phospholipase A2 to This Atherogenic Profile

Eva Hurt-Camejo, Silvia Paredes, Lluis Masana, German Camejo, Peter Sartipy, Birgitta Rosengren,Javier Pedreno, Joan Carles Vallve, Pere Benito, and Olov Wiklund

2768

The Osteoprotegerin/Receptor Activator of Nuclear Factor [Kappa]B/Receptor Activator of Nuclear Factor [Kappa]B Ligand System in Cartilage

Hajime Komuro, Tsaiwei Olee, Klaus Khn, Jacqueline Quach, Diana C. Brinson, Alex Shikhman, Jean Valbracht, Lilo Creighton-Achermann, and Martin Lotz

2777

Anabolic and Catabolic Gene Expression Pattern Analysis in Normal Versus Osteoarthritic Cartilage Using Complementary DNA-Array Technology

Thomas Aigner, Alexander Zien, Angelika Gehrsitz, Pia Margarethe Gebhard, and Louise McKenna

2790

Activation of the Inducible Nitric Oxide Synthase Pathway Contributes to Inflammation-Induced Osteoporosis by Suppressing Bone Formation and Causing Osteoblast Apoptosis

Kenneth J. Armour, Katharine E. Armour, Robert J. van 't Hof, David M. Reid, Xiao-Qing Wei, Foo Y. Liew, and Stuart H. Ralston

2797

Systemic Lupus Erythematosus in Three Ethnic Groups. IX. Differences in Damage Accrual

Graciela S. Alarcon, Gerald McGwin, Jr., Alfred A. Bartolucci, Jeffrey Roseman, Jeffrey Lisse, Barri J. Fessler, Holly M. Bastian, Alan W. Friedman, and John D. Reveille, for the LUMINA Study Group

2807

Linkage Analysis of Human Systemic Lupus Erythematosus-Related Traits: A Principal Component Approach

Shaoqi Rao, Jane M. Olson, Kathy L. Moser, Courtney Gray-McGuire, Gail R. Bruner, Jennifer Kelly, and John B. Harley

2819

Association of Tumor Necrosis Factor Receptor Type II Polymorphism 196R With Systemic Lupus Erythematosus in the Japanese: Molecular and Functional Analysis

Chika Morita, Takahiko Horiuchi, Hiroshi Tsukamoto, Nobuaki Hatta, Yuji Kikuchi, Yojiro Arinobu, Takeshi Otsuka, Takuya Sawabe, Shin-ichi Harashima, Kohei Nagasawa, and Yoshiyuki Niho

Improvement in Skin Thickening in Systemic Sclerosis Associated With Improved Survival

Virginia D. Steen and Thomas A. Medsger, Jr.

2828

2836

Response of Wegener's Granulomatosis to Anti-CD20 Chimeric Monoclonal Antibody Therapy

Ulrich Specks, Fernando C. Fervenza, Thomas J. McDonald, and Marie C. E. Hogan

2841

PTX3 in Small-Vessel Vasculitides: An Independent Indicator of Disease Activity Produced at Sites of Inflammation

Fausto Fazzini, Giuseppe Peri, Andrea Doni, Giacomo Dell'Antonio, Elena Dal Cin, Enrica Bozzolo, Francesca D'Auria, Luisa Praderio, Gianfranco Ciboddo, Maria Grazia Sabbadini, Angelo A. Manfredi, Alberto Mantovani, and Patrizia Rovere Querini

2851

Antineutrophil Cytoplasmic Antibodies Stabilize Adhesion and Promote Migration of Flowing Neutrophils on Endothelial Cells

David J. Radford, N. Thin Luu, Peter Hewins, Gerard B. Nash, and Caroline O. S. Savage

2862

Demyelination Occurring During Anti-Tumor Necrosis Factor [alpha] Therapy for Inflammatory Arthritides

Niveditha Mohan, Evelyne T. Edwards, Thomas R. Cupps, Patrick J. Oliverio, Glenn Sandberg, Heidi Crayton, John R. Richert, and Jeffrey N. Siegel

2870

Statins Prevent Endothelial Cell Activation Induced by Antiphospholipid (Anti-[beta]2-Glycoprotein I) Antibodies: Effect on the Proadhesive and Proinflammatory Phenotype

Pier L. Meroni, Elena Raschi, Cinzia Testoni, Angela Tincani, Genesio Balestrieri, Raffaella Molteni, Munther A. Khamashta, Elena Tremoli, and Marina Camera

2879

TIA-1 Regulates the Production of Tumor Necrosis Factor [alpha] in Macrophages, but Not in Lymphocytes

Keiko Saito, Samantha Chen, Monica Piecyk, and Paul Anderson

2888

Adenovirus-Based Overexpression of Tissue Inhibitor of Metalloproteinases 1 Reduces Tissue Damage in the Joints of Tumor Necrosis Factor [alpha] Transgenic Mice

Georg Schett, Silvia Hayer, Makiyeh Tohidast-Akrad, Beatrice Jahn Schmid, Susanne Lang, Birgit Trk, Franz Kainberger, Sylva Haralambous, George Kollias, Andrew C. Newby, Qingbo Xu, Gunter Steiner, and Josef Smolen

2899

Differential Expression Pattern of the Antiapoptotic Proteins, Bcl-2 and FLIP, in Experimental Arthritis

Harris Perlman, Hongtao Liu, Constantinos Georganas, Alisa E. Koch, Eli Shamiyeh, G. Kenneth Haines III, and Richard M. Pope

2909

Amelioration of Joint Disease in a Rat Model of Collagen-Induced Arthritis by M40403, a Superoxide Dismutase Mimetic

Daniela Salvemini, Emanuela Mazzon, Laura Dugo, Ivana Serraino, Angela De Sarro, Achille P. Caputi, and Salvatore Cuzzocrea

2922

Increased Resistance to Collagen-Induced Arthritis in CD44-Deficient DBA/1 Mice

Reinout Stoop, Hidehito Kotani, John D. McNeish, Ivan G. Otterness, and Katalin Mikecz

2932

The Impact of Ultrasonography on Diagnosis and Management of Patients With Musculoskeletal Conditions

Z. Karim, R. J. Wakefield, P. G. Conaghan, C. A. Lawson, E. Goh, M. A. Quinn, P. Astin, P. O'Connor, W. W. Gibbon, and P. Emery

2933

Treatment of Longstanding Active Giant Cell Arteritis With Infliximab: Report of Four Cases

Fabrizio Cantini, Laura Niccoli, Carlo Salvarani, Angela Padula, and Ignazio Olivieri

2936

Infliximab Treatment of Severe Ankylosing Spondylitis: One-Year Followup

Jan Brandt, Hildrun Haibel, Joachim Sieper, Jacqueline Reddig, and Jurgen Braun

2937

Effects of Anti-Tumor Necrosis Factor [alpha] on Synovium in Patients With Spondylarthropathy: Comment on the Article by Baeten et al

Gaye Cunnane

2938

Reply

Dominique Baeten, Elli Kruithof, Filip Van den Bosch, Herman Mielants, Eric M. Veys, and Filip De Keyser

2939

Possible Infection With Brucella in Patients With Spondylitis: Comment on the Article by Brandt et al and the Clinical Images by Mercie and Leleu

Yojana Gokhale

2940

Correlation Among Macrophage Inflammatory Protein 1[alpha] Levels, Matrix Metalloproteinase 8 Levels, and Systemic Inflammation in Rheumatoid Arthritis: Comment on the Articles by Yamanaka et al and Mattey et al

Werner C. Kullich and Gert Klein

2941

Reduced Bone Mineral Density in Men With Rheumatoid Arthritis: Comment on the Article by Haugeberg et al

Joan M. Nolla and Lourdes Mateo

2941

Reply

Tore K. Kvien and Glenn Haugeberg

2942

Are Cases of Rheumatoid Arthritis in Smokers and Lifelong Nonsmokers Representative of Different Rheumatoid Disease Processes? Comment on the Article by Harrison et al

David Hutchinson

2943

Disease Activity and Survival in Vasculitis: Comment on the Article by Gayraud et al

Eric L. Matteson

2943

Reply

Martine Gayraud, Loic Guillevin, and Philippe le Toumelin

2943

Possible Association Between Glucosamine Treatment and Renal Toxicity: Comment on the Letter by Danao-Camara

Marie-Paule Guillaume and Anne Peretz

2944

Fetal Cell Trafficking and Dermal Fibrosis: Comment on the Article by Christner et al

Bharath Srivatsa and Elizabeth A. Bonney

2945

Reply

Paul J. Christner and Carol M. Artlett

2946

Late-Breaking Abstracts and Second-Year Fellow Abstracts, American College of Rheumatology 2001 Annual Scientific Meeting

2953

Reviewers

2958

Contents, Volume 44, 2001

2986

Indexes

13A

ACR Announcements

Cover image: The figure on the cover (from Armour et al, page 2794) illustrates immunofluorescence staining of apoptotic osteoblasts in a section of tibia from a mouse treated with talc. In animals, administration of talc causes inflammation-induced osteoporosis, providing a model to investigate the bone loss associated with many forms of arthritis. In the current study, this model was used to determine the role of inducible nitric oxide synthase.