2461

Editorial: Is There a Role for Ginger in the Treatment of Osteoarthritis?

Donald M. Marcus and Maria E. Suarez-Almazor

2463

Editorial: Synovial Fluid-Polymerase Chain Reaction Detection of Pathogens: What Does It Really Mean?

Leonard H. Sigal

2467

Review: The Role of Tissue Factor in the Antiphospholipid Syndrome

Pablo-Manuel Dobado-Berrios, Chari Lopez-Pedrera, Francisco Velasco, and Maria-Jose Cuadrado

2477

Do Silicone Breast Implants Cause Rheumatologic Disorders? A Systematic Review for a Court-Appointed National Science Panel

Peter Tugwell, George Wells, Joan Peterson, Vivian Welch, Jacqueline Page, Carolyn Davison, Jessie McGowan, David Ramroth, and Beverley Shea

2485

Ability of the American College of Rheumatology 1987 Criteria to Predict Rheumatoid Arthritis in Patients With Early Arthritis and Classification of These Patients Two Years Later

Alain Saraux, Jean M. Berthelot, Gerard Chales, Catherine Le Henaff, Jean B. Thorel, Sylvie Hoang, Isabelle Valls, Valerie Devauchelle, Antoine Martin, Dominique Baron, Yvon Pennec, Estelle Botton, Jean Y. Mary, Paul Le Goff, and Pierre Youinou

2492

Magnetic Resonance Imaging and Miniarthroscopy of Metacarpophalangeal Joints: Sensitive Detection of Morphologic Changes in Rheumatoid Arthritis

Benedikt Ostendorf, Ralf Peters, Paul Dann, Arnd Becker, Axel Scherer, Freya Wedekind, Johannes Friemann, Klaus-Peter Schulitz, Ulrich Modder, and Matthias Schneider

2503

Relationships of Matrix Metalloproteinases and Their Inhibitors to Cartilage Proteoglycan and Collagen Turnover and Inflammation as Revealed by Analyses of Synovial Fluids From Patients With Rheumatoid Arthritis

Naoki Ishiguro, Takayasu Ito, Takeshi Oguchi, Toshihisa Kojima, Hisashi Iwata, Mirela Ionescu, and A. Robin Poole

2512

Vascular Endothelial Growth Factor Expression by Activated Synovial Leukocytes in Rheumatoid Arthritis: Critical Involvement of the Interaction With Synovial Fibroblasts

Tsuyoshi Kasama, Fumitaka Shiozawa, Kazuo Kobayashi, Nobuyuki Yajima, Michio Hanyuda, Hiroko T. Takeuchi, Yoshiaki Mori, Masao Negishi, Hirotsugu Ide, and Mitsuru Adachi

2525

The C677T Mutation in the Methylenetetrahydrofolate Reductase Gene: A Genetic Risk Factor for Methotrexate-Related Elevation of Liver Enzymes in Rheumatoid Arthritis Patients

Annelies E. van Ede, Roland F. J. M. Laan, Henk J. Blom, Tom W. J. Huizinga, Cees J. Haagsma, Belinda A. J. Giesendorf, Theo M. de Boo, and Leo B. A. van de Putte

2531

Effects of a Ginger Extract on Knee Pain in Patients With Osteoarthritis

R. D. Altman and K. C. Marcussen

2539

Evaluation of the Structure-Modifying Effects of Diacerein in Hip Osteoarthritis: ECHODIAH, a Three-Year, Placebo-Controlled Trial

Maxime Dougados, Minh Nguyen, Laurent Berdah, Bernard Mazieres, Eric Vignon, and Michel Lequesne, for the ECHODIAH Investigators Study Group

2548

A Large Icelandic Family With Early Osteoarthritis of the Hip Associated With a Susceptibility Locus on Chromosome 16p

Thorvaldur Ingvarsson, Stefán Einar Stefánsson, Jeffrey R. Gulcher, Hjortur Heiðar Jónsson, Helgi Jónsson, Michael L. Frigge, Ebba Pálsdóttir, Guðbjörg Ólafsdóttir, þorbjörg Jónsdóttir, Guðmundur Bragi Walters, L. Stefan Lohmander, and Kári Stefánsson

2556

Age-Related Changes in the Morphology and Deformational Behavior of Knee Joint Cartilage

M. Hudelmaier, C. Glaser, J. Hohe, K.-H. Englmeier, M. Reiser, R. Putz, and F. Eckstein

2562

Age-Related Decrease in Susceptibility of Human Articular Cartilage to Matrix Metalloproteinase-Mediated Degradation: The Role of Advanced Glycation End Products

Jeroen DeGroot, Nicole Verzijl, Marion J. G. Wenting-Van Wijk, Ruud A. Bank, Floris P. J. G. Lafeber, Johannes W. J. Bijlsma, and Johan M. TeKoppele

2572

Preferential Recognition of a Fragment Species of Osteoarthritic Synovial Fluid Fibronectin by Antibodies to the Alternatively Spliced EIIIA Segment

John H. Peters, Steven Carsons, Kenneth Kalunian, Skye McDougall, Mika Yoshida, Fred Ko, Milena van der Vliet-Hristova, and Theodore J. Hahn

2586

Matrix Turnover in Human Cartilage Repair Tissue in Autologous Chondrocyte Implantation

Sally Roberts, Anthony P. Hollander, Bruce Caterson, Janis Menage, and James B. Richardson

2599

Antisense Inhibition of CD44 Tailless Splice Variant in Human Articular Chondrocytes Promotes Hyaluronan Internalization

Hong Jiang, Cheryl B. Knudson, and Warren Knudson

2611

The Relationship of Health-Related Quality of Life to Prevalent and Incident Vertebral Fractures in Postmenopausal Women With Osteoporosis: Results From the Multiple Outcomes of Raloxifene Evaluation Study

Stuart L. Silverman, Michael E. Minshall, Wei Shen, Kristine D. Harper, and Sunny Xie, on behalf of the Health-Related Quality of Life Subgroup of the Multiple Outcomes of Raloxifene Evaluation Study

2620

Immunoglobulin V[lambda] Light Chain Gene Usage in Patients With Sjogren's Syndrome

Sabine Kaschner, Arne Hansen, Annett Jacobi, Karin Reiter, Nancy L. Monson, Marcus Odendahl, Gerd R. Burmester, Peter E. Lipsky, and Thomas Dorner

2633

Ectopic Expression of the B Cell-Attracting Chemokine BCA-1 (CXCL13) on Endothelial Cells and Within Lymphoid Follicles Contributes to the Establishment of Germinal Center-Like Structures in Sjogren's Syndrome

Nicole Amft, S. John Curnow, Dagmar Scheel-Toellner, Ash Devadas, Jane Oates, John Crocker, John Hamburger, John Ainsworth, John Mathews, Mike Salmon, Simon J. Bowman, and Christopher D. Buckley

2642

Secondary Necrosis Is a Source of Proteolytically Modified Forms of Specific Intracellular Autoantigens: Implications for Systemic Autoimmunity

Xiwei Wu, Christine Molinaro, Neal Johnson, and Carlos A. Casiano

2653

Oxidative Stress in Scleroderma: Maintenance of Scleroderma Fibroblast Phenotype by the Constitutive Up-Regulation of Reactive Oxygen Species Generation Through the NADPH Oxidase Complex Pathway

Paola Sambo, Silvia Svegliati Baroni, Michele Luchetti, Paolo Paroncini, Stefano Dusi, Guido Orlandini, and Armando Gabrielli

2665

Overexpression of Monocyte Chemoattractant Protein 1 in Systemic Sclerosis: Role of Platelet-Derived Growth Factor and Effects on Monocyte Chemotaxis and Collagen Synthesis

Oliver Distler, Thomas Pap, Otylia Kowal-Bielecka, Rotraud Meyringer, Serena Guiducci, Michael Landthaler, Jurgen Scholmerich, Beat A. Michel, Renate E. Gay, Marco Matucci-Cerinic, Steffen Gay, and Ulf Muller-Ladner

2679

Chlamydia and Borrelia DNA in Synovial Fluid of Patients With Early Undifferentiated Oligoarthritis: Results of a Prospective Study

S. Schnarr, N. Putschky, M. C. Jendro, H. Zeidler, M. Hammer, J. G. Kuipers, and J. Wollenhaupt

2686

A Double-Blind Trial of Colchicine in Behçet's Syndrome

Sebahattin Yurdakul, Cem Mat, Yalcin Tuzun, Yilmaz Ozyazgan, Vedat Hamuryudan, Omer Uysal, Mustafa Senocak, and Hasan Yazici

2693

Linkage Mapping of a Novel Susceptibility Locus for Behcet's Disease to Chromosome 6p22-23

Ahmet Gul, Ali H. Hajeer, Jane Worthington, William E. R. Ollier, and Alan J. Silman

2697

Amelioration of Arthritis in Two Murine Models Using Antibodies to Oncostatin M

C. Plater-Zyberk, J. Buckton, S. Thompson, J. Spaull, E. Zanders, J. Papworth, and P. F. Life

2703

Demonstration of Response in Rheumatoid Arthritis Patients Who Are Nonresponders According to the American College of Rheumatology 20% Criteria: The Paradox of Beneficial Treatment Effects in Nonresponders in the ATTRACT Trial

Maarten Boers, for the COBRA Study Group

2705

Failure to Verify H-ras Mutations in Arthritic Synovium: Comment on the Article by Roivainen et al

Anne Roivainen, Fei Zhu, Esa Sipola, Tuomas Yli-Jama, and Paavo Toivanen

2705

Cytochrome P2 Polymorphisms and Susceptibility to Scleroderma: Comment on the Article by Povey et al

Janardan P. Pandey, Paul J. Nietert, and Richard M. Silver

2706

Reply

A. Povey, M. J. Guppy, M. Wood, A. J. Silman, C. Knight, and C. M. Black

21A

Cover image: The figure on the cover (from Amft et al, page 2638) illustrates 3-color immunofluorescence to assess the relationship between chemokines and T and B cells expressing chemokine receptors in lymphoid aggregates in Sjogren's syndrome. Blue indicates CD3, red indicates the chemokine receptor CXCR4, and green indicates the chemokine stromal cell-derived factor 1. The ectopic expression of chemokines in exocrine gland tissue may contribute to the development of lymphoid aggregates in this disease.