2215

Editorial: Atherosclerosis and Lupus: A Work in Progress

Michael D. Lockshin, Jane E. Salmon, and Mary J. Roman

2218

Editorial: Rheumatoid Arthritis Is More Than Cytokines: Autoimmunity and Rheumatoid Arthritis

Josef S. Smolen and Gunter Steiner

2221

Editorial: The Utility of Immunologic Laboratory Tests in Patients With Rheumatic Diseases

Arthur Kavanaugh

2224

Review: The Innate Immune System in Rheumatoid Arthritis

William P. Arend

2235

Treatment of Early Seropositive Rheumatoid Arthritis: A Two-Year, Double-Blind Comparison of Minocycline and Hydroxychloroquine

James R. O'Dell, Kent W. Blakely, Jack A. Mallek, P. James Eckhoff, Rob D. Leff, Steven J. Wees, Kelly M. Sems, Ana M. Fernandez, William R. Palmer, Lynell W. Klassen, Gail A. Paulsen, Claire E. Haire, and Gerald F. Moore

2242

Inflammation and Damage in an Individual Joint Predict Further Damage in That Joint in Patients With Early Rheumatoid Arthritis

Maarten Boers, Piet J. Kostense, Arco C. Verhoeven, and Sjef van der Linden, for the COBRA Trial Group

2247

The Inheritance of Rheumatoid Arthritis in Iceland

Struan F. A. Grant, Gudmar Thorleifsson, Michael L. Frigge, Jon Thorsteinsson, Brynja Gunnlaugsdottir, rni Jon Geirsson, Magnus Gudmundsson, Arnor Vikingsson, Kristjan Erlendsson, Julius Valsson, Helgi Jonsson, Daniel F. Gudbjartsson, Kari Stefansson, Jeffrey R. Gulcher, and Kristjan Steinsson

2255

Specific Presence of Intracellular Citrullinated Proteins in Rheumatoid Arthritis Synovium: Relevance to Antifilaggrin Autoantibodies

Dominique Baeten, Isabelle Peene, Ann Union, Lydie Meheus, Mireille Sebbag, Guy Serre, Eric M. Veys, and Filip De Keyser

2263

Early Joint Erosions and Serum Levels of Matrix Metalloproteinase 1, Matrix Metalloproteinase 3, and Tissue Inhibitor of Metalloproteinases 1 in Rheumatoid Arthritis

Gaye Cunnane, Oliver FitzGerald, Charlotte Beeton, Tim E. Cawston, and Barry Bresnihan

2275

Expression of Recombination-Activating Genes and Terminal Deoxynucleotidyl Transferase and Secondary Rearrangement of Immunoglobulin [Kappa] Light Chains in Rheumatoid Arthritis Synovial Tissue

Zhixin Zhang, Xing Wu, Brent H. Limbaugh, and S. Louis Bridges, Jr.

2285

Structural Evaluation of Articular Cartilage: Potential Contribution of Magnetic Resonance Techniques Used in Clinical Practice

Pierre Olivier, Damien Loeuille, Astrid Watrin, Frederic Walter, Stephanie Etienne, Patrick Netter, Pierre Gillet, and Alain Blum

2296

Synergistic Induction of Matrix Metalloproteinase 1 by Interleukin-1[alpha] and Oncostatin M in Human Chondrocytes Involves Signal Transducer and Activator of Transcription and Activator Protein 1 Transcription Factors via a Novel Mechanism

J. B. Catterall, S. Carrere, P. J. T. Koshy, B. A. Degnan, W. D. Shingleton, C. E. Brinckerhoff, J. Rutter, T. E. Cawston, and A. D. Rowan

2311

Tumor Necrosis Factor [alpha]-Dependent Proinflammatory Gene Induction Is Inhibited by Cyclic Tensile Strain in Articular Chondrocytes In Vitro

Ping Long, Robert Gassner, and Sudha Agarwal

2320

In Vivo Dual Inhibition of Cyclooxygenase and Lipoxygenase by ML-3000 Reduces the Progression of Experimental Osteoarthritis: Suppression of Collagenase 1 and Interleukin-1[beta] Synthesis

Dragan V. Jovanovic, Julio C. Fernandes, Johanne Martel-Pelletier, Francois-Cyril Jolicoeur, Pascal Reboul, Stefan Laufer, Susanne Tries, and Jean-Pierre Pelletier

2331

Traditional Framingham Risk Factors Fail to Fully Account for Accelerated Atherosclerosis in Systemic Lupus Erythematosus

John M. Esdaile, Michal Abrahamowicz, Tamara Grodzicky, Yin Li, Constantina Panaritis, Roxane du Berger, Robert Cote, Steven A. Grover, Paul R. Fortin, Ann E. Clarke, and Jean-Luc Senecal

2338

Association of Osteoporosis and Cardiovascular Disease in Women With Systemic Lupus Erythematosus

Rosalind Ramsey-Goldman and Susan Manzi

2342

Decreases in Anti-Double-Stranded DNA Levels Are Associated With Concurrent Flares in Patients With Systemic Lupus Erythematosus

Audrey Ho, Laurence S. Magder, Susan G. Barr, and Michelle Petri

2350

A Decrease in Complement Is Associated With Increased Renal and Hematologic Activity in Patients With Systemic Lupus Erythematosus

Audrey Ho, Susan G. Barr, Laurence S. Magder, and Michelle Petri

2358

Characterization of a Prolactin Gene Polymorphism and Its Associations With Systemic Lupus Erythematosus

Adam Stevens, David Ray, Aliya Alansari, Ali Hajeer, Wendy Thomson, Rachelle Donn, William E. R. Ollier, Jane Worthington, and Julian R. E. Davis

2367

Increased Prevalence of Autoantibodies to Ku Antigen in African American Versus White Patients With Systemic Lupus Erythematosus

Jingsong Wang, Minoru Satoh, Fathima Kabir, Melody Shaw, Mary Ann Domingo, Rizwan Mansoor, Krista M. Behney, Xingwen Dong, Robert G. Lahita, Hanno B. Richards, and Westley H. Reeves

2371

Infliximab in Patients With Primary Sjogren's Syndrome: A Pilot Study

Serge D. Steinfeld, Paul Demols, Isabelle Salmon, Robert Kiss, and Thierry Appelboom

2376

Novel Fragments of the Sjogren's Syndrome Autoantigens [alpha]-Fodrin and Type 3 Muscarinic Acetylcholine Receptor Generated During Cytotoxic Lymphocyte Granule-Induced Cell Death

Kanneboyina Nagaraju, Amy Cox, Livia Casciola-Rosen, and Antony Rosen

2387

Higher Frequency of Allele 2 of the Interleukin-1 Receptor Antagonist Gene in Patients With Juvenile Idiopathic Arthritis

Jiri Vencovsky, Katerina Jarosova, arka Ruzickova, Dana Nemcova, Jaroslava Niederlova, Seza Ozen, Mehmet Alikasifoglu, Aysin Bakkaloglu, William E. R. Ollier, and Rizgar A. Mageed

2392

The Reprogrammed Host: Chlamydia Trachomatis-Induced Up-Regulation of Glycoprotein 130 Cytokines, Transcription Factors, and Antiapoptotic Genes

Simone Hess, Claudia Rheinheimer, Felicitas Tidow, Gerda Bartling, Christian Kaps, Joerg Lauber, Jan Buer, and Andreas Klos

2402

The Occurrence of Autoantibodies to Matrilin 1 Reflects a Tissue-Specific Response to Cartilage of the Respiratory Tract in Patients With Relapsing Polychondritis

Ann-Sofie Hansson, Dick Heinegard, Jean-Charles Piette, Harald Burkhardt, and Rikard Holmdahl

2413

Genetic Ablation of Interferon-[gamma] Up-Regulates Interleukin-1[beta] Expression and Enables the Elicitation of Collagen-Induced Arthritis in a Nonsusceptible Mouse Strain

Yajaira B. Guedez, Karen B. Whittington, Jenny L. Clayton, Leo A. B. Joosten, Fons A. J. van de Loo, Wim B. van den Berg, and Edward F. Rosloniec

2425

Membrane Complement Regulators Protect Against the Development of Type II Collagen-Induced Arthritis in Rats

Masashi Mizuno, Kazuhiro Nishikawa, O. Brad Spiller, B. Paul Morgan, Noriko Okada, Hidechika Okada, and Seiichi Matsuo

2435

Strong Acceleration of Murine Lupus by Injection of the SmD183-119 Peptide

Gabriela Riemekasten, Annegret Kawald, Catarina Wei\S, Andrea Meine, Jeannette Marell, Rolf Klein, Berthold Hocher, Christian Meisel, Gert Hausdorf, Rudi Manz, Thomas Kamradt, Gerd-R. Burmester, and Falk Hiepe

2446

A Molecular Analysis of the Low Serum Deoxyribonuclease Activity in Lupus Patients

Monty B. Tew, Randall W. Johnson, John D. Reveille, and Filemon K. Tan

2448

David S. Pisetsky

2448

Use of Acetaminophen in the Treatment of Osteoarthritis in Patients With Liver Disease: Comment on the 2000 Update of the American College of Rheumatology Recommendations for Management of Hip and Knee Osteoarthritis

Joseph M. Lynch and Tiziana M. Fox

2449

Use of Acetaminophen in Alcoholic Patients: Comment on the 2000 Update of the American College of Rheumatology Recommendations for Management of Hip and Knee Osteoarthritis

Richard C. Dart and Edwin K. Kuffner

2449

Fluoroscopically Directed Steroid Instillation in the Treatment of Hip Osteoarthritis: Safety and Efficacy in 510 Cases

Kenneth R. Margules

2450

Concerns About the Methodology Used in Developing the 2000 Update of the American College of Rheumatology Recommendations for Management of Hip and Knee Osteoarthritis

Paul A. Dieppe

2451

A Critique of the 2000 Update of the American College of Rheumatology Recommendations for Management of Hip and Knee Osteoarthritis

Kenneth D. Brandt

2455

Reply

Marc C. Hochberg

2456

The Efficacy of Thalidomide in Severe Refractory Seronegative Spondylarthropathy: Comment on the Letter by Breban et al

Liane Lee, Ron Lawford, and H. Patrick McNeil

2457

Reply

Maxime Breban and Maxime Dougados

2458

Granulocyte Colony-Stimulating Factor Therapy Resulting in a Flare of Systemic Lupus Erythematosus: Comment on the Article by Yang and Hamilton

Jacques-Eric Gottenberg, Sophie Roux, Frederic Desmoulins, Didier Clerc, and Xavier Mariette

2459

Reply

Yuan H. Yang and John A. Hamilton

2460

Brown's Syndrome: An Unusual Cause of Diplopia in Rheumatoid Arthritis

T. M. Lawson, S. Siebert, and B. D. Williams

11A

Cover image: The figure on the cover (from Jovanovic et al, page 2327) illustrates immunostaining for interleukin-1 in the synovial membrane of a dog with osteoarthritis treated with a novel antiinflammatory agent. This agent affects both cyclooxygenase and 5-lipoxygenase and reduces the development of osteoarthritis in a dog model, with interleukin-1 expression being one measure of its activity.