1723

Editorial: Anti-Ro/SSA Antibodies and Congenital Heart Block: Necessary but Not Sufficient

Jill P. Buyon, Mimi Y. Kim, Joshua A. Copel, and Deborah M. Friedman

1728

Editorial: Response Criteria and Criteria for Clinically Important Improvement: Separate and Equal?

Michael M. Ward

1730

Review: The Immune Tolerance Network and Rheumatic Disease: Immune Tolerance Comes to the Clinic

Betty Diamond, Jeffrey Bluestone, and David Wofsy

1736

Prognostic Factors for Radiographic Damage in Early Rheumatoid Arthritis: A Multiparameter Prospective Study

B. Combe, M. Dougados, P. Goupille, A. Cantagrel, J. F. Eliaou, J. Sibilia, O. Meyer, J. Sany, J.-P. Daures, and A. Dubois

1744

Synovial Tissue Protease Gene Expression and Joint Erosions in Early Rheumatoid Arthritis

Gaye Cunnane, Oliver FitzGerald, Klaus M. Hummel, Peter P. Youssef, Renate E. Gay, Steffen Gay, and Barry Bresnihan

1754

Production of Cytokines, Vascular Endothelial Growth Factor, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases 1 by Tenosynovium Demonstrates Its Potential for Tendon Destruction in Rheumatoid Arthritis

Abhilash Jain, Jagdeep Nanchahal, Linda Troeberg, Patricia Green, and Fionula Brennan

1761

Corticotropin-Releasing Hormone Signaling in Synovial Tissue From Patients With Early Inflammatory Arthritis Is Mediated by the Type 1[alpha] Corticotropin-Releasing Hormone Receptor

Alice N. McEvoy, Barry Bresnihan, Oliver FitzGerald, and Evelyn P. Murphy

1768

The Clinical Meaning of Functional Outcome Scores in Children With Juvenile Arthritis

Helen Dempster, Michelle Porepa, Nancy Young, and Brian M. Feldman

1775

Juvenile Arthritis and Autoimmunity to Type II Collagen

L. K. Myers, G. C. Higgins, T. H. Finkel, A. M. Reed, J. W. Thompson, R. C. Walton, J. Hendrickson, N. C. Kerr, R. K. Pandya-Lipman, B. V. Shlopov, P. Stastny, A. E. Postlethwaite, and A. H. Kang

1782

A Novel 5`-Flanking Region Polymorphism of Macrophage Migration Inhibitory Factor Is Associated With Systemic-Onset Juvenile Idiopathic Arthritis

R. P. Donn, E. Shelley, W. E. R. Ollier, W. Thomson, and the British Paediatric Rheumatology Study Group

1786

Effect of Alignment of the Medial Tibial Plateau and X-Ray Beam on Apparent Progression of Osteoarthritis in the Standing Anteroposterior Knee Radiograph

Steven A. Mazzuca, Kenneth D. Brandt, Paul A. Dieppe, Michael Doherty, Barry P. Katz, and Kathleen A. Lane

1795

Expression of Clusterin in the Superficial Zone of Bovine Articular Cartilage

Ilyas M. Khan, Donald M. Salter, Mike T. Bayliss, Brian M. Thomson, and Charles W. Archer

1800

Anti-Fas-Induced Apoptosis in Chondrocytes Reduced by Hyaluronan: Evidence for CD44 and CD54 (Intercellular Adhesion Molecule 1) Involvement

Gina Lisignoli, Francesco Grassi, Nicoletta Zini, Stefania Toneguzzi, Anna Piacentini, Diego Guidolin, Carla Bevilacqua, and Andrea Facchini

1808

Formation and Phenotype of Cell Clusters in Osteoarthritic Meniscus

Marie-Pierre Hellio Le Graverand, Paul Sciore, Jonna Eggerer, J. P. Rattner, Eric Vignon, Leona Barclay, David A. Hart, and J. B. Rattner

1819

Alternative Messenger RNA Splicing and Enzyme Forms of Cathepsin B in Human Osteoarthritic Cartilage and Cultured Chondrocytes

Simona Berardi, Angela Lang, Georgios Kostoulas, Dorothy Horler, Edy M. Vilei, and Antonio Baici

1832

Risk of Congenital Complete Heart Block in Newborns of Mothers With Anti-Ro/SSA Antibodies Detected by Counterimmunoelectrophoresis: A Prospective Study of 100 Women

Antonio Brucato, Micol Frassi, Franco Franceschini, Rolando Cimaz, David Faden, Maria Pia Pisoni, Marina Muscara, Gabriele Vignati, Marco Stramba-Badiale, Luca Catelli, Andrea Lojacono, Ilaria Cavazzana, Anna Ghirardello, Francesca Vescovi, Pier Franca Gambari, Andrea Doria, Pier Luigi Meroni, and Angela Tincani

1836

A New Type of Acquired C1 Inhibitor Deficiency Associated With Systemic Lupus Erythematosus

Patrice Cacoub, Veronique Fremeaux-Bacchi, Isabelle De Lacroix, Francoise Guillien, Marcel-Francis Kahn, Michel D. Kazatchkine, Pierre Godeau, and Jean Charles Piette

1841

Calcium-Channel Blockers for Raynaud's Phenomenon in Systemic Sclerosis

Andrew E. Thompson, Beverley Shea, Vivian Welch, Deborah Fenlon, and Janet E. Pope

1848

Fetal Cell Microchimerism in Tissue From Multiple Sites in Women With Systemic Sclerosis

Kirby L. Johnson, J. Lee Nelson, Daniel E. Furst, Peter A. McSweeney, Drucilla J. Roberts, Dong-Kai Zhen, and Diana W. Bianchi

1855

Abnormalities in Fibrillin 1-Containing Microfibrils in Dermal Fibroblast Cultures From Patients With Systemic Sclerosis (Scleroderma)

Debra D. Wallis, Filemon K. Tan, Cay M. Kielty, Misty D. Kimball, Frank C. Arnett, and Dianna M. Milewicz

Evidence of 5-Lipoxygenase Overexpression in the Skin of Patients With Systemic Sclerosis: A Newly Identified Pathway to Skin Inflammation in Systemic Sclerosis

1865

Otylia Kowal-Bielecka, Oliver Distler, Michel Neidhart, Peter Kunzler, Janine Rethage, Michael Nawrath, Anna Carossino, Thomas Pap, Ulf Muller-Ladner, Beat A. Michel, Stanislaw Sierakowski, Marco Matucci-Cerinic, Renate E. Gay, and Steffen Gay

1876

Ankylosing Spondylitis Assessment Group Preliminary Definition of Short-Term Improvement in Ankylosing Spondylitis

Jennifer J. Anderson, Gabriel Baron, Desiree van der Heijde, David T. Felson, and Maxime Dougados

1887

Improved Differentiation Between Churg-Strauss Syndrome and Wegener's Granulomatosis by an Artificial Neural Network

W. H. Schmitt, R. Linder, E. Reinhold-Keller, and W. L. Gross

1897

Inhibitor of Nuclear Factor [Kappa]B Kinase [beta] Is a Key Regulator of Synovial Inflammation

Paul P. Tak, Danielle M. Gerlag, Karl R. Aupperle, Deliana A. van de Geest, Marieke Overbeek, Brydon L. Bennett, David L. Boyle, Anthony M. Manning, and Gary S. Firestein

1908

Effects of Low-Dose, Noncytotoxic, Intraarticular Liposomal Clodronate on Development of Erosions and Proteoglycan Loss in Established Antigen-Induced Arthritis in Rabbits

Arnoldas Ceponis, Eero Waris, Jukka Monkkonen, Leena Laasonen, Mika Hyttinen, Svetlana A. Solovieva, Roeland Hanemaaijer, Andreas Bitsch, and Yrjo T. Konttinen

1917

Importance of Dose of Type II Collagen in Suppression of Collagen-Induced Arthritis by Nasal Tolerance

Catherine J. Derry, Nicola Harper, D. Huw Davies, John J. Murphy, and Norman A. Staines

1928

Multipotent Mesenchymal Stem Cells From Adult Human Synovial Membrane

Cosimo De Bari, Francesco Dell'Accio, Przemyslaw Tylzanowski, and Frank P. Luyten

1943

Fibroblast-Mediated Delivery of Growth Factor Complementary DNA Into Mouse Joints Induces Chondrogenesis but Avoids the Disadvantages of Direct Viral Gene Transfer

K. Gelse, Q.-J. Jiang, T. Aigner, T. Ritter, K. Wagner, E. Poschl, K. von der Mark, and H. Schneider

1954

A Deceptive Case of Amyloid Myopathy: Clinical and Magnetic Resonance Imaging Features

Keith M. Hull, Lawrence Griffith, Ralph W. Kuncl, and Fredrick M. Wigley

1959

Early Hydroxychloroquine Macular Toxicity

Ann E. Warner

1962

Successful Treatment of Patients With Systemic Lupus Erythematosus by Immunoadsorption With a C1q Column: A Pilot Study

Barbara Pfueller, Karsten Wolbart, Anne Bruns, Gerd-Rudiger Burmester, and Falk Hiepe

1964

Increased Risk of Ankylosing Spondylitis Among First-Born Children: Comment on the Article by Baudoin et al

Roula Said-Nahal, Corinne Miceli-Richard, Maxime Dougados, and Maxime Breban

1965

Reply

Irene E. van der Horst-Bruinsma, P. Dick Bezemer, and Ben A. C. Dijkmans

1965

The Sapporo Criteria for Antiphospholipid Syndrome: Comment on the Article by Lockshin et al

Marcel Weber, Gilles Hayem, and Olivier Meyer

1966

Hepatitis With Interface Inflammation and IgG, IgM, and IgA Anti-Double-Stranded DNA Antibodies Following Infliximab Therapy: Comment on the Article by Charles et al

Gulrukh Saleem, Shuan C. Li, Bruce R. MacPherson, and Sheldon M. Cooper

1968

Reply

Peter Charles and Ravinder N. Maini

11A

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