985

Review: Vascular Cell Adhesion Molecule 1 (CD106): A Multifaceted Regulator of Joint Inflammation

Rebecca A. Carter and Ian P. Wicks

995

Editorial: C-Reactive Protein: A Rheumatologist's Friend Revisited

John P. Atkinson

997

Complement Activation in Patients With Rheumatoid Arthritis Mediated in Part by C-Reactive Protein

Esmeralda T. H. Molenaar, Alexandre E. Voskuyl, Atoosa Familian, Gerard J. van Mierlo, Ben A. C. Dijkmans, and C. Erik Hack

1003

Activated Human T Cells Directly Induce Osteoclastogenesis From Human Monocytes: Possible Role of T Cells in Bone Destruction in Rheumatoid Arthritis Patients

Shigeru Kotake, Nobuyuki Udagawa, Masayuki Hakoda, Makio Mogi, Kazuki Yano, Eisuke Tsuda, Ken Takahashi, Takefumi Furuya, Shigeru Ishiyama, Kang-Jung Kim, Seiji Saito, Toshio Nishikawa, Naoyuki Takahashi, Akifumi Togari, Taisuke Tomatsu, Tatsuo Suda, and Naoyuki Kamatani

1013

Potential Role of HOXD9 in Synoviocyte Proliferation

Nguyen Dinh Khoa, Minako Nakazawa, Tomoko Hasunuma, Toshihiro Nakajima, Hiroshi Nakamura, Tetsuji Kobata, and Kusuki Nishioka

1022

Differential Expression of Chemokine Receptors on Peripheral Blood, Synovial Fluid, and Synovial Tissue Monocytes/Macrophages in Rheumatoid Arthritis

Kenneth J. Katschke, Jr., James B. Rottman, Jeffrey H. Ruth, Shixin Qin, Lijun Wu, Gregory LaRosa, Paul Ponath, Christy C. Park, Richard M. Pope, and Alisa E. Koch

1033

Reduced Disability at Five Years With Early Treatment of Inflammatory Polyarthritis: Results From a Large Observational Cohort, Using Propensity Models to Adjust for Disease Severity

Nicola J. Wiles, Mark Lunt, Elizabeth M. Barrett, Marwan Bukhari, Alan J. Silman, Deborah P. M. Symmons, and Graham Dunn

1043

The Effects of Intravenous Doxycycline Therapy for Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

E. William St.Clair, William E. Wilkinson, David S. Pisetsky, Daniel J. Sexton, Richard Drew, Virginia B. Kraus, and Robert A. Greenwald

1048

Leflunomide-Associated Weight Loss in Rheumatoid Arthritis

Jonathan S. Coblyn, Nancy Shadick, and Simon Helfgott

1052

American College of Rheumatology Criteria for Improvement in Rheumatoid Arthritis Should Only Be Calculated From Scores That Decrease on Improvement

Maarten Boers, Arco C. Verhoeven, and Sjef van der Linden

1056

The Role of C-C Chemokines and Their Receptors in Osteoarthritis

Guo-Hua Yuan, Kayo Masuko-Hongo, Masahiro Sakata, Jun-Ichiro Tsuruha, Hiroyuki Onuma, Hiroshi Nakamura, Haruhito Aoki, Tomohiro Kato, and Kusuki Nishioka

1071

Up-Regulated Expression of the Phosphodiesterase Nucleotide Pyrophosphatase Family Member PC-1 Is a Marker and Pathogenic Factor for Knee Meniscal Cartilage Matrix Calcification

Kristen Johnson, Sanshiro Hashimoto, Martin Lotz, Kenneth Pritzker, James Goding, and Robert Terkeltaub

1082

The Splice Variants VEGF121 and VEGF189 of the Angiogenic Peptide Vascular Endothelial Growth Factor Are Expressed in Osteoarthritic Cartilage

Thomas Pufe, Wolf Petersen, Bernhard Tillmann, and Rolf Mentlein

1089

Preferential Incorporation of Glucosamine Into the Galactosamine Moieties of Chondroitin Sulfates in Articular Cartilage Explants

Elizabeth A. Noyszewski, Krzysztof Wroblewski, George R. Dodge, Sagar Kudchodkar, Jennifer Beers, A. V. S. Sarma, and Ravinder Reddy

1096

A Synthetic Triterpenoid Selectively Inhibits the Induction of Matrix Metalloproteinases 1 and 13 by Inflammatory Cytokines

Kimberlee S. Mix, John A. Mengshol, Ulrike Benbow, Matthew P. Vincenti, Michael B. Sporn, and Constance E. Brinckerhoff

1105

Problems in the Development and Validation of Questionnaire-Based Screening Instruments for Ascertaining Cases With Symptomatic Knee Osteoarthritis: The Framingham Study

Michael LaValley, Timothy E. McAlindon, Stephen Evans, Christine E. Chaisson, and David T. Felson

1114

Fc[epsilon] Receptor Type I [gamma] Chain Replaces the Deficient T Cell Receptor [zeta]  Chain in T Cells of Patients With Systemic Lupus Erythematosus

Edith J. Enyedy, Madhusoodana P. Nambiar, Stamatis-Nick C. Liossis, Gregory Dennis, Gary M. Kammer, and George C. Tsokos

1122

Systemic Lupus Erythematosus in Adults Is Associated With Previous Epstein-Barr Virus Exposure

Judith A. James, Barbara R. Neas, Kathy L. Moser, Teresa Hall, Gail R. Bruner, Andrea L. Sestak, and John B. Harley

1127

Dysfunction of T Cell Receptor AV24AJ18+,BV11+ Double-Negative Regulatory Natural Killer T Cells in Autoimmune Diseases

Satoshi Kojo, Yoshihiro Adachi, Hiroshi Keino, Masaru Taniguchi, and Takayuki Sumida

1139

Cholestasis in Juvenile Dermatomyositis: Report of Three Cases

Ricardo A. G. Russo, Maria M. Katsicas, Maria Davila, Mirta Ciocca, and Marta Zelazko

1143

Enhanced In Vivo Lipid Peroxidation in Scleroderma Spectrum Disorders

Jean-Luc Cracowski, Claudine Marpeau, Patrick H. Carpentier, Bernard Imbert, Mark Hunt, Francoise Stanke-Labesque, and Germain Bessard

1149

Etanercept Combined With Conventional Treatment in Wegener's Granulomatosis: A Six-Month Open-Label Trial to Evaluate Safety

John H. Stone, Misty L. Uhlfelder, David B. Hellmann, Sonya Crook, Nita-Marie Bedocs, and Gary S. Hoffman

1155

Inflamed Shoulder Structures in Polymyalgia Rheumatica With Normal Erythrocyte Sedimentation Rate

Fabrizio Cantini, Carlo Salvarani, Ignazio Olivieri, Laura Niccoli, Pierluigi Macchioni, Luigi Boiardi, Mariano Mastrorosato, Giovanni Ciancio, Angela Padula, Alessandro Bozza, and Fabrizio Rubini

1160

A National Study of Medical Care Expenditures for Musculoskeletal Conditions: The Impact of Health Insurance and Managed Care

Edward Yelin, Aldona Herrndorf, Laura Trupin, and Dean Sonneborn

1170

Joint Swelling as a Predictor of Death From Cardiovascular Disease in a Population Study of Pima Indians

Lennart T. H. Jacobsson, Carl Turesson, Robert L. Hanson, Stanley Pillemer, Maurice L. Sievers, David J. Pettitt, Peter H. Bennett, and William C. Knowler

1177

Predictors of Outcome in Patients With Oligoarthritis: Results of a Protocol of Intraarticular Corticosteroids to All Clinically Active Joints

Michael Green, Helena Marzo-Ortega, Richard J. Wakefield, Paul Astin, Susanna Proudman, Philip G. Conaghan, Lesley Hordon, and Paul Emery

1184

Predictors of Outcomes of Carpal Tunnel Release

Jeffrey N. Katz, Elena Losina, Benjamin C. Amick III, Anne H. Fossel, Louis Bessette, and Robert B. Keller

1194

Activity Loss and the Onset of Depressive Symptoms: Do Some Activities Matter More Than Others?

Patricia P. Katz and Edward H. Yelin

1203

Circulating Activated Endothelial Cells in Systemic Lupus Erythematosus: Further Evidence for Diffuse Vasculopathy

Robert Clancy, Galina Marder, Victor Martin, H. Michael Belmont, Steven B. Abramson, and Jill Buyon

1209

IL10.G Microsatellites Mark Promoter Haplotypes Associated With Protection Against the Development of Reactive Arthritis in Finnish Patients

Wiebke Kaluza, Marjatta Leirisalo-Repo, Elisabeth Marker-Hermann, Pia Westman, Esther Reuss, Rosula Hug, Ksenija Mastrovic, Beate Stradmann-Bellinghausen, Kaisa Granfors, Peter R. Galle, and Thomas Hohler

1215

Chronic Relapsing Homologous Collagen-Induced Arthritis in DBA/1 Mice as a Model for Testing Disease-Modifying and Remission-Inducing Therapies

Anne-Marie Malfait, Richard O. Williams, Angela Sara Malik, Ravinder N. Maini, and Marc Feldmann

1225

Intercellular Adhesion Molecule 1 Expression is Required for Antiphospholipid Antibody-Induced Pregnancy Loss

Lian Mo and Jane E. Salmon

1226

Microchimerism in Japanese Patients With Systemic Sclerosis

Naomi Ichikawa, Shigeru Kotake, Masayuki Hakoda, and Naoyuki Kamatani

1229

Cyclooxygenase 2 Inhibitors and Thrombogenicity Production: Comment on the Article by Crofford et al

Rhoda Sperling, Ned Braunstein, Jeffrey Melin, and Alise Reicin

1230

Reply

Leslie J. Crofford, Kevin T. McDonagh, Alvin H. Schmaier, and James C. Oates

23A

ACR Announcements

Cover image: The figure on the cover (from Mix et  al, page 1100) depicts a human chondrosarcoma cell invading a  matrix of collagen. Matrix degradation, mediated by matrix metalloproteinases, is a key step in the pathogenesis of osteoarthritis and rheumatoid arthritis. As shown in the article by Mix et al, synthetic compounds can prevent degradation and could have therapeutic potential.