739

Review: Human Receptors for Immunoglobulin G: Key Elements in the Pathogenesis of Rheumatic Disease

Jane E. Salmon and Luminita Pricop

751

Editorial: Does Pain in Fibromyalgia Reflect Somatization?

John B. Winfield

754

High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation in Patients With Rheumatoid Arthritis: Results of an Open Study to Assess Feasibility, Safety, and Efficacy

Robert J. Verburg, Aike A. Kruize, Frank H. J. van den Hoogen, Willem E. Fibbe, Eefke J. Petersen, Frank Preijers, Jacob K. Sont, Renee M. Y. Barge, Johannes W. J. Bijlsma, Leo B. van de Putte, Ferdinand C. Breedveld, and Jacob M. van Laar

761

The Stress Protein BiP Is Overexpressed and Is a Major B and T Cell Target in Rheumatoid Arthritis

Stefan Bla\S, Ann Union, Jos Raymackers, Frank Schumann, Ute Ungethum, Sabine Muller-Steinbach, Filip De Keyser, Joachim-Michael Engel, and Gerd R. Burmester

772

Blockade of Wnt-5A/Frizzled 5 Signaling Inhibits Rheumatoid Synoviocyte Activation

Malini Sen, Mario Chamorro, Jack Reifert, Maripat Corr, and Dennis A. Carson

782

Involvement of the Nuclear Orphan Receptor NURR1 in the Regulation of Corticotropin-Releasing Hormone Expression and Actions in Human Inflammatory Arthritis

Evelyn P. Murphy, Alice McEvoy, Orla M. Conneely, Barry Bresnihan, and Oliver FitzGerald

794

Expression of Angiogenic Factors in Juvenile Rheumatoid Arthritis:Correlation With Revascularization of Human Synovium Engrafted Into SCID Mice

Michael P. Scola, Tomoyuki Imagawa, Gregory P. Boivin, Edward H. Giannini, David N. Glass, Raphael Hirsch, and Alexei A. Grom

802

Cytokine Gene Polymorphisms and Susceptibility to Juvenile Idiopathic Arthritis

R. P. Donn, J. H. Barrett, A. Farhan, A. Stopford, L. Pepper, E. Shelley, N. Davies, W. E. R. Ollier, W. Thomson, and the British Paediatric Rheumatology Study Group

811

The Effect of Estrogen Plus Progestin on Knee Symptoms and Related Disability in Postmenopausal Women: The Heart and Estrogen/Progestin Replacement Study, a Randomized, Double-Blind, Placebo-Controlled Trial

Michael C. Nevitt, David T. Felson, Elizabeth N. Williams, and Deborah Grady for the Heart and Estrogen/Progestin Replacement Study Research Group

819

Acupuncture for Osteoarthritis of the Knee: A Systematic Review

Jeanette Ezzo, Victoria Hadhazy, Stephen Birch, Lixing Lao, Gary Kaplan, Marc Hochberg, and Brian Berman

826

Regulation of YKL-40 Production by Human Articular Chondrocytes

Julia S. Johansen, Tsaiwei Olee, Paul A. Price, Sanshiro Hashimoto, Robert L. Ochs, and Martin Lotz

838

Implication of Cartilage Intermediate Layer Protein in Cartilage Destruction in Subsets of Patients With Osteoarthritis and Rheumatoid Arthritis

Jun-ichiro Tsuruha, Kayo Masuko-Hongo, Tomohiro Kato, Masahiro Sakata, Hiroshi Nakamura, and Kusuki Nishioka

846

Imaging of Collagen and Proteoglycan in Cartilage Sections Using Fourier Transform Infrared Spectral Imaging

Kimberlee Potter, Linda H. Kidder, Ira W. Levin, E. Neil Lewis, and Richard G. S. Spencer

856

Systemic Lupus Erythematosus and Autoimmunity Alterations of Dendritic Cells in Systemic Lupus Erythematosus: Phenotypic and Functional Deficiencies

Clemens Scheinecker, Bettina Zwolfer, Markus Koller, Georg Manner, and Josef S. Smolen

866

Biologic Activity and Plasma Clearance of Prolactin-IgG Complex in Patients With Systemic Lupus Erythematosus

Alfredo Leanos-Miranda, Karina A. Chavez-Rueda, and Francisco Blanco-Favela

876

Identification of an Fc[gamma] Receptor-Independent Mechanism by Which Intravenous Immunoglobulin Ameliorates Antiphospholipid Antibody-Induced Thrombogenic Phenotype

Silvia S. Pierangeli, Ricardo Espinola, Xiaowei Liu, E. Nigel Harris, and Jane E. Salmon

884

A Novel Role for Interleukin-18 in Human Natural Killer Cell Death: High Serum Levels and Low Natural Killer Cell Numbers in Patients With Systemic Autoimmune Diseases

Kazutaka Shibatomi, Hiroaki Ida, Satoshi Yamasaki, Tomoki Nakashima, Tomoki Origuchi, Atsushi Kawakami, Kiyoshi Migita, Yojiro Kawabe, Mitsuhiro Tsujihata, Paul Anderson, and Katsumi Eguchi

893

Association of Fibrillin 1 Single-Nucleotide Polymorphism Haplotypes With Systemic Sclerosis in Choctaw and Japanese Populations

Filemon K. Tan, Ning Wang, Masataka Kuwana, Ranajit Chakraborty, Constantin A. Bona, Dianna M. Milewicz, and Frank C. Arnett

902

Pulmonary Capillary Endothelial Dysfunction in Early Systemic Sclerosis

Stylianos E. Orfanos, Ekaterini Psevdi, Nikolas Stratigis, David Langleben, John D. Catravas, Michael Kyriakidis, Haralampos M. Moutsopoulos, Charis Roussos, and Panayiotis G. Vlachoyiannopoulos

912

A Disease-Specific Activity Index for Wegener's Granulomatosis: Modification of the Birmingham Vasculitis Activity Score

John H. Stone, Gary S. Hoffman, Peter A. Merkel, Yuan-I Min, Misty L. Uhlfelder, David B. Hellmann, Ulrich Specks, Nancy B. Allen, John C. Davis, Robert F. Spiera, Leonard H. Calabrese, Fredrick M. Wigley, Nicola Maiden, Robert M. Valente, John L. Niles, Kenneth H. Fye, Joseph W. McCune, E. William St.Clair, and Raashid A. Luqmani, for the International Network for the Study of the Systemic Vasculitides (INSSYS)

921

IgG From Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Positive Patients Stimulates Greater Activation of Primed Neutrophils Than IgG From Proteinase 3-Antineutrophil Cytoplasmic Antibody-Positive Patients

L. Harper, D. Radford, T. Plant, M. Drayson, D. Adu, and C. O. S. Savage

931

Expression of Host Defense Scavenger Receptors in Spondylarthropathy

Noriyuki Seta, Kaisa Granfors, Hany Sahly, Jens G. Kuipers, Yeong Wook Song, Dominique Baeten, Eric M. Veys, Walter Maksymowych, Elisabeth Marker-Hermann, Jieruo Gu, Feng Huang, Juha Kirveskari, and David Tak Yan Yu

940

Epidemiology, Outcomes, and Treatment Features of Somatization Predict the Onset of Chronic Widespread Pain: Results of a Large Population-Based Study

John McBeth, Gary J. Macfarlane, Sidney Benjamin, and Alan J. Silman

947

Mechanisms of Disease: Models and Genetics Expression of Sox9 and Type IIA Procollagen During Attempted Repair of Articular Cartilage Damage in a Transgenic Mouse Model of Osteoarthritis

Heli Salminen, Eero Vuorio, and Anna-Marja Saamanen

956

Development and Characteristics of a Synovial-Like Interface Membrane Around Cemented Tibial Hemiarthroplasties in a Novel Rat Model of Aseptic Prosthesis Loosening

Geza Pap, Andreas Machner, Torsten Rinnert, Dorothy Horler, Renate E. Gay, Helmut Schwarzberg, Wolfram Neumann, Beat A. Michel, Steffen Gay, and Thomas Pap

964

Treatment of Chronic Sialadenitis in a Murine Model of Sjogren's Syndrome by Local fasL Gene Transfer

Martin Fleck, Huang-Ge Zhang, Earl R. Kern, Hui-Chen Hsu, Ulf Muller-Ladner, and John D. Mountz

974

Hereditary Angioedema With a De Novo Mutation of Exon 8 in the C1 Inhibitor Gene Showing Recurrent Edema of the Hands Around the Peripheral Joints: Importance for the Differential Diagnosis of Joint Swelling

Eiji Sugiyama, Tetsuo Ozawa, Hirofumi Taki, Muneharu Maruyama, Naohiro Yamashita, Masayuki Ohta, Masayoshi Hirata, and Masashi Kobayashi

978

Bilateral Symmetric Inflammatory Reaction to Hylan G-F 20 Injection

Peter B. Martens

979

Ferritin and Serum Transferrin Receptor Predict Iron Deficiency in Anemic Patients With Rheumatoid Arthritis

Irene E. M. Bultink, Willem F. Lems, Rob J. van de Stadt, Huibert J. Dinant, Anja Leyte, Diana S. Park, Margaret H. M. T. de Koning, and Ben A. C. Dijkmans

981

Systemic Lupus Erythematosus in Three Ethnic Groups. VIII. Lack of Association of Glutathione S-Transferase Null Alleles With Disease Manifestations

Monty B. Tew, Chul W. Ahn, Alan W. Friedman, John D. Reveille, Filemon K. Tan, Graciela S. Alarcon, Holly M. Bastian, Barri J. Fessler, Gerald McGwin, Jr., and Jeffrey R. Lisse

984

Cyclooxygenase 2 Inhibition and Thrombosis: Comment on the Article by Crofford et al

Robert McMurray

25A

ACR Announcements

Cover image: The figure on the cover (from Salmon  and Pricop, page 741) illustrates that Fc receptors are a family of  cell surface molecules found widely on a variety of immune cells. These receptors can bind immune complexes and transduce signals that are key for immune regulation. As such, they may play an important role in the pathogenesis of autoimmune and inflammatory diseases.