493

Review: Involvement of the Hypothalamic-Pituitary-Adrenal/Gonadal Axis and the Peripheral Nervous System in Rheumatoid Arthritis: Viewpoint Based on a Systemic Pathogenetic Role

Rainer H. Straub and Maurizio Cutolo

508

Treatment of Polyarteritis Nodosa, Microscopic Polyangiitis, and Churg-Strauss Syndrome: Where Do We Stand?

Carol A. Langford

513

Winners of the 2000 American College of Rheumatology Slide Competition

Catherine M. Meyer and the ACR Audiovisual Aids Subcommittee

515

A Randomized Two-Year Study of the Effects of Dynamic Strength Training on Muscle Strength, Disease Activity, Functional Capacity, and Bone Mineral Density in Early Rheumatoid Arthritis

Arja Hakkinen, Tuulikki Sokka, Antero Kotaniemi, and Pekka Hannonen

523

Increased Mortality in Adults With a History of Juvenile Rheumatoid Arthritis: A Population-Based Study

Anthony R. French, Tom Mason, Audrey M. Nelson, W. Michael O'Fallon, and Sherine E. Gabriel

528

Indirect Medical Costs in Early Rheumatoid Arthritis: Composition of and Changes in Indirect Costs Within the First Three Years of Disease

S. Merkesdal, J. Ruof, O. Schoffski, K. Bernitt, H. Zeidler, and W. Mau

535

Influence of Shared Epitope-Negative HLA-DRB1 Alleles on Genetic Susceptibility to Rheumatoid Arthritis

Denis Reviron, Aleth Perdriger, Eric Toussirot, Daniel Wendling, Nathalie Balandraud, Sandrine Guis, Gilbert Semana, Pierre Tiberghien, Pierre Mercier, and Jean Roudier

541

Lymph Draining From Foot Joints in Rheumatoid Arthritis Provides Insight Into Local Cytokine and Chemokine Production and Transport to Lymph Nodes

Waldemar L. Olszewski, J. Pazdur, E. Kubasiewicz, M. Zaleska, Conrad J. Cooke, and Norman E. Miller

550

Levels of Interleukin-18 and Its Binding Inhibitors in the Blood Circulation of Patients With Adult-Onset Still's Disease

Masanori Kawashima, Masahiro Yamamura, Madoka Taniai, Hiroshi Yamauchi, Tadao Tanimoto, Masashi Kurimoto, Shoji Miyawaki, Tetsuki Amano, Tsutomu Takeuchi, and Hirofumi Makino

561

Shift Toward T Helper 1 Cytokines by Type II Collagen-Reactive T Cells in Patients With Rheumatoid Arthritis

Sung-Hwan Park, Do-June Min, Mi-La Cho, Wan-Uk Kim, Jeehee Youn, Won Park, Chul-Soo Cho, and Ho-Youn Kim

570

Infection Efficiency of Type 5 Adenoviral Vectors in Synovial Tissue Can Be Enhanced With a Type 16 Fiber

Paulien H. Goossens, Menzo J. E. Havenga, Elsbet Pieterman, Angelique A. Lemckert, Ferdinand C. Breedveld, Abraham Bout, and Tom W. J. Huizinga

578

An Intrinsic Inhibitor of Inflammation in Cartilage

Mukundan G. Attur, Mandar N. Dave, Steven Stuchin, Aaron J. Kowalski, German Steiner, Steven B. Abramson, David T. Denhardt, and Ashok R. Amin

585

Matrix Metalloproteinase and Proinflammatory Cytokine Production by Chondrocytes of Human Osteoarthritic Cartilage: Associations With Degenerative Changes

Lynne C. Tetlow, Daman J. Adlam, and David E. Woolley

595

Peroxisome Proliferator-Activated Receptor [gamma] Activators Inhibit Interleukin-1[beta]-Induced Nitric Oxide and Matrix Metalloproteinase 13 Production in Human Chondrocytes

Hassan Fahmi, John A. Di Battista, Jean-Pierre Pelletier, Francois Mineau, Pierre Ranger, and Johanne Martel-Pelletier

608

Cyclic Tensile Strain Suppresses Catabolic Effects of Interleukin-1[beta] in Fibrochondrocytes From the Temporomandibular Joint

Sudha Agarwal, Ping Long, Robert Gassner, Nicholas P. Piesco, and Michael J. Buckley

618

The Fc[gamma] Receptor IIIA-158F Allele Is a Major Risk Factor for the Development of Lupus Nephritis Among Caucasians but Not Non-Caucasians

Victoria A. Seligman, Charlyn Suarez, Raymond Lum, Sven E. Inda, Doris Lin, Hongzhe Li, Jean L. Olson, Michael F. Seldin, and Lindsey A. Criswell

626

Immunoglobulin V[Kappa] Light Chain Gene Analysis in Patients With Sjogren's Syndrome

Claudia Heimbacher, Arne Hansen, Axel Pruss, Annett Jacobi, Karin Reiter, Peter E. Lipsky, and Thomas Dorner

638

Polymorphisms of the Ro52 Gene Associated With Anti-Ro 52-kd Autoantibodies in Patients With Primary Sjogren's Syndrome

Britt Nakken, Roland Jonsson, and Anne Isine Bolstad

647

Long-Term Outcome of Mothers of Children With Isolated Heart Block in Finland

Heikki Julkunen and Marianne Eronen

653

The Disability Index of the Health Assessment Questionnaire Is a Predictor and Correlate of Outcome in the High-Dose Versus Low-Dose Penicillamine in Systemic Sclerosis Trial

Philip J. Clements, Weng Kee Wong, Eric L. Hurwitz, Daniel E. Furst, Maureen Mayes, Barbara White, Fredrick Wigley, Michael Weisman, Walter Barr, Larry Moreland, Thomas A. Medsger, Jr., Virginia Steen, Richard W. Martin, David Collier, Arthur Weinstein, Edward Lally, John Varga, Steven R. Weiner, Brian Andrews, Micha Abeles, and James R. Seibold

662

Cytochrome P2 Polymorphisms and Susceptibility to Scleroderma Following Exposure to Organic Solvents

A. Povey, M. J. Guppy, M. Wood, C. Knight, C. M. Black, and A. J. Silman

666

Long-Term Followup of Polyarteritis Nodosa, Microscopic Polyangiitis, and Churg-Strauss Syndrome: Analysis of Four Prospective Trials Including 278 Patients  

Martine Gayraud, Loic Guillevin, Philippe le Toumelin, Pascal Cohen, Francois Lhote, Philippe Casassus, Bernard Jarrousse, and the French Vasculitis Study Group

676

Mechanisms of Disease: Models and Genetics Invasiveness of Synovial Fibroblasts Is Regulated by p53 in the SCID Mouse In Vivo Model of Cartilage Invasion

Thomas Pap, Karlfried R. Aupperle, Steffen Gay, Gary S. Firestein, and Renate E. Gay

682

Variations in Susceptibility to Proteoglycan-Induced Arthritis and Spondylitis Among C3H Substrains of Mice: Evidence of Genetically Acquired Resistance to Autoimmune Disease

Tibor T. Glant, Tamas Bardos, Csaba Vermes, Raman Chandrasekaran, Juan C. Valdez, Jeffrey M. Otto, David Gerard, Sonja Velins, Gyorgy Lovasz, Jian Zhang, Katalin Mikecz, and Alison Finnegan

693

Elevated Proapoptotic Bax and Caspase 3 Activation in the NOD.scid Model of Sjogren's Syndrome

Reiji Masago, Sonomi Aiba-Masago, Norman Talal, Fabio Jimenez Zuluaga, Ibtisam Al-Hashimi, Michael Moody, C. Allen Lau, Ammon B. Peck, Jason Brayer, Michael G. Humphreys-Beher, and Howard Dang

703

Cysteine Protease Activity Is Up-Regulated in Inflamed Ankle Joints of Rats With Adjuvant-Induced Arthritis and Decreases With In Vivo Administration of a Vinyl Sulfone Cysteine Protease Inhibitor

Sandra L. Biroc, Steffen Gay, Klaus Hummel, Catherine Magill, James T. Palmer, Donna R. Spencer, Susan Sa, Jeffrey L. Klaus, Beat A. Michel, David Rasnick, and Renate E. Gay

712

Activation of a Fibroblast-Specific Enhancer of the Pro[alpha]2(I) Collagen Gene in Tight-Skin Mice

Christopher P. Denton, Bing Zheng, Xu Shiwen, Zhaoping Zhang, George Bou-Gharios, Heidi Eberspaecher, Carol M. Black, and Benoit de Crombrugghe

723

Development of the Tight-Skin Phenotype in Immune-Deficient Mice

Tatjana D. Dodig, Kristine T. Mack, Deborah F. Cassarino, and Stephen H. Clark

728

Prolonged Remission Without Treatment After Autologous Stem Cell Transplantation for Refractory Childhood Systemic Lupus Erythematosus

N. M. Wulffraat, E. A. M. Sanders, S. S. M. Kamphuis, G. T. Rijkers, W. Kuis, M. Lilien, and I. C. M. Slaper-Cortenbach

731

Up-Regulated Expression of Transforming Growth Factor [beta] Receptors in Dermal Fibroblasts in Skin Sections From Patients With Localized Scleroderma

Masahide Kubo, Hironobu Ihn, Kenichi Yamane, and Kunihiko Tamaki

735

Updating the American College of Rheumatology Preliminary Classification Criteria for Systemic Sclerosis: Addition of Severe Nailfold Capillaroscopy Abnormalities Markedly Increases the Sensitivity for Limited Scleroderma

Lilian Scussel Lonzetti, France Joyal, Jean-Pierre Raynauld, Andre Roussin, Jean-Richard Goulet, Eric Rich, Denis Choquette, Yves Raymond, and Jean-Luc Senecal

737

Possible Role of Antiidiotypes in the Loss of Anti-Topoisomerase I Antibodies: Comment on the Article by Kuwana et al

Haraldine A. Stafford, Zi-Jian Pan, and Camille J. Anderson

737

Reply

Masataka Kuwana and Junichi Kaburaki

22A

ACR Announcements

Cover image: The figure on the cover (from Tetlow et al, page 588) depicts staining for matrix metalloproteinase 8 (MMP-8) in osteoarthritic cartilage. In this specimen, MMP-8 is localized to chondrocytes in the superficial zone near the articular surface. In concert with data on staining for other MMPs and interleukin-1 and tumor necrosis factor [alpha], these findings help elucidate the phenotype of chondrocytes in osteoarthritis and the process of cartilage destruction.