247

ACR Presidential Address: The Future Is Now

Joseph D. Croft, Jr.

259

Review: The Role of Osteoprotegerin and Receptor Activator of Nuclear Factor [Kappa]B Ligand in the Pathogenesis and Treatment of Rheumatoid Arthritis

Lorenz C. Hofbauer and Armin E. Heufelder

260

Involvement of ErbB-2 in Rheumatoid Synovial Cell Growth

Koichiro Satoh, Shinichi Kikuchi, Masayuki Sekimata, Yukihito Kabuyama, Miwako K. Homma, and Yoshimi Homma

266

Overexpression of Transcription Factor Ets-1 in Rheumatoid Arthritis Synovial Membrane: Regulation of Expression and Activation by Interleukin-1 and Tumor Necrosis Factor [alpha]

Kurt Redlich, Hans P. Kiener, George Schett, Makiyeh Tohidast-Akrad, Edgar Selzer, Irene Radda, Georg H. Stummvoll, Carl W. Steiner, Marion Groger, Peter Bitzan, Peter Zenz, Josef S. Smolen, and Gunter Steiner

275

Interferon-[gamma]-Inducing Activity of Interleukin-18 in the Joint With Rheumatoid Arthritis

Masahiro Yamamura, Masanori Kawashima, Madoka Taniai, Hiroshi Yamauchi, Tadao Tanimoto, Masashi Kurimoto, Yoshitaka Morita, Yasukazu Ohmoto, and Hirofumi Makino

286

Tumor Necrosis Factor Markers Show Sex-Influenced Association With Rheumatoid Arthritis

Joanne M. Meyer, Jinfeng Han, and George Moxley

296

Recognition of Cell Surface GD3 by Monoclonal Antibody Anti-6C2 in Rheumatoid Arthritis Synovial Fluid: Expression on Human T Cells With Transendothelial Migratory Activity

Toshio Homma, Osamu Hosono, Satoshi Iwata, Susumu Ando, Katsutoshi Sasaki, Tatsunari Nishi, Hiroshi Kawasaki, Hirotoshi Tanaka, and Chikao Morimoto

307

Rheumatoid Arthritis in Southern Spain: Toward Elucidation of a Unifying Role of the HLA Class II Region in Disease Predisposition

M. Pascual, A. Nieto, M. A. Lopez-Nevot, L. Ramal, L. Mataran, A. Caballero, A. Alonso, J. Martin, and E. Zanelli

315

HLA Haplotype Analysis in Finnish Patients With Rheumatoid Arthritis

Juha Tuokko, Sergei Nejentsev, Reijo Luukkainen, Auli Toivanen, and Jorma Ilonen

323

The Association of Cigarette Smoking With Disease Outcome in Patients With Early Inflammatory Polyarthritis

Beverley J. Harrison, Alan J. Silman, Nicola J. Wiles, David G. I. Scott, and Deborah P. M. Symmons

331

Correlation of Power Doppler Sonography With Vascularity of the Synovial Tissue of the Knee Joint in Patients With Osteoarthritis and Rheumatoid Arthritis

Markus Walther, Harry Harms, Veit Krenn, Stephan Radke, Trutz-Peter Faehndrich, and Frank Gohlke

339

Development of Fulminant Hepatitis B (Precore Variant Mutant Type) After the Discontinuation of Low-Dose Methotrexate Therapy in a Rheumatoid Arthritis Patient

Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa, Yusaku Mita, Kojiro Hata, Noriko Saito, Masatoshi Kikuchi, Kazukiyo Yoshida, Masaaki Nakano, and Fumitake Gejyo

343

Effects of Intraarticular Glucocorticoids on Macrophage Infiltration and Mediators of Joint Damage in Osteoarthritis Synovial Membranes: Findings in a Double-Blind, Placebo-Controlled Study

Laurel Young, Amel Katrib, Carolyn Cuello, Ute Vollmer-Conna, James V. Bertouch, Peter J. Roberts-Thomson, Michael J. Ahern, Malcolm D. Smith, and Peter P. Youssef

351

Interleukin-1[beta] Down-Regulates the Expression of Glucuronosyltransferase I, a Key Enzyme Priming Glycosaminoglycan Biosynthesis: Influence of Glucosamine on Interleukin-1[beta]-Mediated Effects in Rat Chondrocytes

Jean-Noel Gouze, Karim Bordji, Sandrine Gulberti, Bernard Terlain, Patrick Netter, Jacques Magdalou, Sylvie Fournel-Gigleux, and Mohamed Ouzzine

361

Low-Binding Alleles of Fc[gamma] Receptor Types IIA and IIIA Are Inherited Independently and Are Associated With Systemic Lupus Erythematosus in Hispanic Patients

Ricardo Zuniga, Sonia Ng, Margaret G. E. Peterson, John D. Reveille, Bruce A. Baethge, Graciela S. Alarcon, and Jane E. Salmon

368

The Appearance of U1 RNP Antibody Specificities in Sequential Autoimmune Human Antisera Follows a Characteristic Order That Implicates the U1-70 kd and B`/B Proteins as Predominant U1 RNP Immunogens

Eric L. Greidinger and Robert W. Hoffman

376

Anti-Topoisomerase I (Anti-Scl-70) Antibodies in Patients With Systemic Lupus Erythematosus

Helene A. Elicha Gussin, Georghe P. Ignat, John Varga, and Marius Teodorescu

384

Detection of Autoantibodies to Killer Immunoglobulin-Like Receptors Using Recombinant Fusion Proteins for Two Killer Immunoglobulin-Like Receptors in Patients With Systemic Autoimmune Diseases

Toshihiro Matsui, Masataka Otsuka, Katsumi Maenaka, Hiroshi Furukawa, Toshio Yabe, Kazuhiko Yamamoto, Kusuki Nishioka, and Tomohiro Kato

389

The DNA Mismatch Repair Enzyme PMS1 Is a Myositis-Specific Autoantigen

Livia A. Casciola-Rosen, Ann F. Pluta, Paul H. Plotz, Amy E. Cox, Steven Morris, Fredrick M. Wigley, Michelle Petri, Allan C. Gelber, and Antony Rosen

397

Decreased Ras-Mitogen-Activated Protein Kinase Signaling May Cause DNA Hypomethylation in T Lymphocytes From Lupus Patients

Chun Deng, Mariana J. Kaplan, Jun Yang, Donna Ray, Zhiyong Zhang, W. Joseph McCune, Samir M. Hanash, and Bruce C. Richardson

408

``Lymphoid'' Chemokine Messenger RNA Expression by Epithelial Cells in the Chronic Inflammatory Lesion of the Salivary Glands of Sjogren's Syndrome Patients: Possible Participation in Lymphoid Structure Formation

Georgina Xanthou, Mary Polihronis, Athanasios G. Tzioufas, Spyros Paikos, Paschalis Sideras, and Haralampos M. Moutsopoulos

419

Alteration of Peripheral Blood Dendritic Cells in Patients With Primary Sjogren's Syndrome

Yoshio Ozaki, Ryuichi Amakawa, Tomoki Ito, Hiroshi Iwai, Kenichirou Tajima, Kazutaka Uehira, Hideo Kagawa, Yoshiko Uemura, Toshio Yamashita, and Shirou Fukuhara

432

Treatment With a Consensus Peptide Based on Amino Acid Sequences in Autoantibodies Prevents T Cell Activation by Autoantigens and Delays Disease Onset in Murine Lupus

Bevra H. Hahn, Ram R. Singh, Weng Kee Wong, Betty P. Tsao, Ken Bulpitt, and Fanny M. Ebling

442

Molecular and Cellular Mediators of Interleukin-1-Dependent Acute Inflammatory Arthritis

Kate E. Lawlor, Ian K. Campbell, Kristy O'Donnell, Li Wu, and Ian P. Wicks

451

Increased Production of Intracellular Interleukin-1 Receptor Antagonist Type I in the Synovium of Mice With Collagen-Induced Arthritis: A Possible Role in the Resolution of Arthritis

Cem Gabay, Liliana Marinova-Mutafchieva, Richard O. Williams, Jason P. Gigley, Debra M. Butler, Marc Feldmann, and William P. Arend

463

Antineutrophil Cytoplasmic Antibodies Reacting With the Pro Form of Proteinase 3 and Disease Activity in Patients With Wegener's Granulomatosis and Microscopic Polyangiitis

Kimberly A. Russell, David N. Fass, and Ulrich Specks

469

Elevated Interleukin-4 and Interleukin-13 Production by T Cell Lines From Patients With Churg-Strauss Syndrome

M. Kiene, E. Csernok, A. Muller, C. Metzler, A. Trabandt, and W. L. Gross

474

Blockade of Endogenous Transforming Growth Factor [beta] Signaling Prevents Up-Regulated Collagen Synthesis in Scleroderma Fibroblasts: Association With Increased Expression of Transforming Growth Factor [beta] Receptors

Hironobu Ihn, Kenichi Yamane, Masahide Kubo, and Kunihiko Tamaki

481

Widespread Pain Among 11-Year-Old Finnish Twin Pairs

Marja Mikkelsson, Jaakko Kaprio, Jouko J. Salminen, Lea Pulkkinen, and Richard J. Rose

486

Synovial Stimulatory Protein Fragments Copurify With Woodchuck Hepatitis Virus: Implications for the Etiology of Arthritis in Chronic Hepatitis B Virus Infection

Anand Mehta, Xuanyong Lu, Timothy Block, Anthony Willis, Raymond Dwek, Bud Tennant, and Baruch Blumberg

487

The Rate of Recurrence of Isolated Congenital Heart Block: A Population-Based Study

Heiki Julkunen and Marianne Eronen

488

Lupus Band Test Yields Negative Results in Primary Antiphospholipid Syndrome

Jean-Charles Piette, Eduardo Marinho, Du Le Thi Huong, Zahir Amoura, and Camille Frances

490

Monoclonal Expansion of B Cells in Sjogren's Syndrome: Comment on the Article by Martin et al

M. Voulgarelis, A. G. Tzioufas, and H. M. Moutsopoulos

490

Reply

Thierry Martin and Jean-Louis Pasquali

491

Is the Anti-Topoisomerase I Autoantibody Response Associated With a Distinct Amino Acid Sequence in the HLA-DQ[beta]1 Domain?

Ayako Ueki, Yumika Isozaki, Akiko Tomokuni, Takemi Otsuki, Fuminori Hydoh, Haruko Sakaguchi, Shinichiro Tanaka, and Masayasu Kusaka

492

Arthritis Induced by South American Blastomycosis

Morton A. Scheinberg and Moises Cohen

19A

ACR Announcements

Cover image: The figure on the cover (from Walther et al, page 333) illustrates the appearance of a knee joint of a patient with rheumatoid arthritis as visualized by power Doppler sonography (PDS). Vascularity of the synovium can be assessed from the extent of red and yellow coloration. PDS is one of the powerful new technologies to assess synovitis by noninvasive means.