1

Editorial: The American College of Rheumatology Journals: New Directions for Y2K + 1

David S. Pisetsky

3

Review: Synergistic Activity of Interleukin-4 and Interleukin-10 in Suppression of Inflammation and Joint Destruction in Rheumatoid Arthritis

Joel A. G. van Roon, Floris P. J. G. Lafeber, and J. W. J. Bijlsma

13

CD4+,CD28- T Cells in Rheumatoid Arthritis Patients Combine Features of the Innate and Adaptive Immune Systems

Kenneth J. Warrington, Seisuke Takemura, J|f-rg J. Goronzy, and Cornelia M. Weyand

21

Rheumatoid Arthritis Synovial Macrophages Express the Fas-Associated Death Domain-Like Interleukin-1[beta]-Converting Enzyme-Inhibitory Protein and Are Refractory to Fas-Mediated Apoptosis

Harris Perlman, Lisa J. Pagliari, Hongtao Liu, Alisa E. Koch, G. Kenneth Haines, III, and Richard M. Pope

31

Regulation of Angiogenesis by the C-X-C Chemokines Interleukin-8 and Epithelial Neutrophil Activating Peptide 78 in the Rheumatoid Joint

Alisa E. Koch, Michael V. Volin, James M. Woods, Steven L. Kunkel, Matthew A. Connors, Lisa A. Harlow, Drew C. Woodruff, Marie D. Burdick, and Robert M. Strieter

41

Secretion of Anti-Citrulline-Containing Peptide Antibody by B Lymphocytes in Rheumatoid Arthritis

Carelle C. Reparon-Schuijt, Wim J. E. van Esch, Cees van Kooten, Gerard A. Schellekens, Ben A. W. de Jong, Walther J. van Venrooij, Ferdinand C. Breedveld, and Cornelis L. Verweij

48

The Influence of Synovial Fluid on Adenovirus-Mediated Gene Transfer to the Synovial Tissue

Paulien H. Goossens, Ronald Vogels, Elsbet Pieterman, Menzo J. E. Havenga, Abraham Bout, Ferdinand C. Breedveld, Dinko Valerio, and Tom W. J. Huizinga

53

Responsiveness of the Self-Assessed Rheumatoid Arthritis Disease Activity Index to a Flare of Disease Activity

Jaap Fransen, Hansjorg Hauselmann, Beat A. Michel, Miguel Caravatti, and Gerold Stucki

61

Association Between Rheumatoid Arthritis and Polymorphism of Tumor Necrosis Factor Receptor II, But Not Tumor Necrosis Factor Receptor I, in Caucasians

Anne Barton, Sally John, W. E. R. Ollier, Alan Silman, and Jane Worthington

66

The Clinical Significance of Amyloid Fat Deposits in Rheumatoid Arthritis: A Systematic Long-Term Followup Study using Abdominal Fat Aspiration

Emili Gmez-Casanovas, Raimon Sanmarti, Manel Sol, Juan D. Caete, and Jos Muoz-Gmez

73

Hepatocyte Growth Factor Induction of Collagenase 3 Production in Human Osteoarthritic Cartilage: Involvement of the Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase Pathway and a Sensitive p38 Mitogen-Activated Protein Kinase Inhibitor Cascade

Pascal Reboul, Jean-Pierre Pelletier, Ginette Tardif, Mohamed Benderdour, Pierre Ranger, Donald P. Bottaro, and Johanne Martel-Pelletier

85

Human Periosteum-Derived Cells Maintain Phenotypic Stability and Chondrogenic Potential throughout Expansion Regardless of Donor Age

Cosimo De Bari, Francesco Dell'Accio, and Frank P. Luyten

96

Nitric Oxide Regulates Mitochondrial Respiration and Functions of Articular Chondrocytes

Masuhiro Tomita, Eisuke F. Sato, Manabu Nishikawa, Yoshiki Yamano, and Masayasu Inoue

105

Comparison of Differentiated Dendritic Cell Infiltration of Autoimmune and Osteoarthritis Synovial Tissue

Allison R. Pettit, Michael J. Ahern, Simone Zehntner, Malcolm D. Smith, and Ranjeny Thomas

111

Dependence of Interleukin-1-Induced Arthritis on Granulocyte-Macrophage Colony-Stimulating Factor

Yuan H. Yang and John A. Hamilton

120

Early Degradation of Type IX and Type II Collagen with the Onset of Experimental Inflammatory Arthritis

Toshihisa Kojima, Fackson Mwale, Tadashi Yasuda, Christiane Girard, A. Robin Poole, and Sheila Laverty

128

Disease-Modifying Activity of SB 273005, an Orally Active, Nonpeptide [alpha]v[beta]3 (Vitronectin Receptor) Antagonist, in Rat Adjuvant-Induced Arthritis

Alison M. Badger, Simon Blake, Rasesh Kapadia, Susanta Sarkar, Joshua Levin, Barbara A. Swift, Sandy J. Hoffman, George B. Stroup, William H. Miller, Maxine Gowen, and Michael W. Lark

138

Induction of Endothelial Cell Decay-Accelerating Factor by Vascular Endothelial Growth Factor: A Mechanism for Cytoprotection Against Complement-Mediated Injury during Inflammatory Angiogenesis

Justin C. Mason, Elaine A. Lidington, Helen Yarwood, Douglas M. Lublin, and Dorian O. Haskard

151

Insights from a Novel Three-Dimensional In Vitro Model of Lyme Arthritis: Standardized Analysis of Cellular and Molecular Interactions Between Borrelia burgdorferi and Synovial Explants and Fibroblasts

Juliane K. Franz, Olaf Fritze, Michael Rittig, Gernot Key\Ser, Susanne Priem, Josef Zacher, Gerd-R. Burmester, and Andreas Krause

163

The MICA Region Determines the First Modifier Locus in Familial Mediterranean Fever

Isabelle Touitou, Marie-Christine Picot, Cecile Domingo, Cecile Notarnicola, Daniel Cattan, Jacques Demaille, and Isabelle Kone-Paut

170

Treatment of Lupus-Induced Thrombocytopenia with Recombinant Human Interleukin-11

Shamiram Feinglass and Atul Deodhar

176

Genetic Association Between Interleukin-10 Promoter Region Polymorphisms and Primary Sjogren's Syndrome

Janne Hulkkonen, Marja Pertovaara, Jaakko Antonen, Nina Lahdenpohja, Amos Pasternack, and Mikko Hurme

180

Efficacy of Celecoxib, a Cyclooxygenase 2-Specific Inhibitor, in the Treatment of Ankylosing Spondylitis: A Six-Week Controlled Study with Comparison Against Placebo and Against a Conventional Nonsteroidal Antiinflammatory Drug

Maxime Dougados, Jehan-Michel B|fehier, Ir|f4ne Jolchine, Andrei Calin, D|fesir|fee van der Heijde, Ignazio Olivieri, Henning Zeidler, and H|fel|f4ne Herman

186

Immunomodulatory Effects of Anti-Tumor Necrosis Factor [alpha] Therapy on Synovium in Spondylarthropathy: Histologic Findings in Eight Patients from an Open-Label Pilot Study

Dominique Baeten, Elli Kruithof, Filip Van den Bosch, Pieter Demetter, Nancy Van Damme, Claude Cuvelier, Martine De Vos, Herman Mielants, Eric M. Veys, and Filip De Keyser

196

A Functional Polymorphic Variant in the Interleukin-6 Gene Promoter Associated with Low Bone Resorption in Postmenopausal Women

S. L. Ferrari, P. Garnero, S. Emond, H. Montgomery, S. E. Humphries, and S. L. Greenspan

202

Two-Year Effects of Alendronate on Bone Mineral Density and Vertebral Fracture in Patients Receiving Glucocorticoids: A Randomized, Double-Blind, Placebo-Controlled Extension Trial

Jonathan D. Adachi, Kenneth G. Saag, Pierre D. Delmas, Uri A. Liberman, Ronald D. Emkey, Ego Seeman, Nancy E. Lane, Jean-Marc Kaufman, Patrice E. E. Poubelle, Federico Hawkins, Ricardo Correa-Rotter, Charles-Joel Menkes, Jose A. Rodriguez-Portales, Thomas J. Schnitzer, Joel A. Block, Jeffrey Wing, Harris H. McIlwain, Rene Westhovens, Jacques Brown, Jose A. Melo-Gomes, Barry L. Gruber, Melissa J. Yanover, Maria Odette R. Leite, Kerry G. Siminoski, Michael C. Nevitt, John T. Sharp, Marie-Pierre Malice, Thomas Dumortier, Michelle Czachur, Wendy Carofano, and Anastasia Daifotis

212

Arthritis Prevalence and Activity Limitations in Older Adults

Dorothy D. Dunlop, Larry M. Manheim, Jing Song, and Rowland W. Chang

222

Alpha Sleep Characteristics in Fibromyalgia

Suely Roizenblatt, Harvey Moldofsky, Ana Amelia Benedito-Silva, and Sergio Tufik

231

Efficacy and Safety of Desensitization to Allopurinol following Cutaneous Reactions

Adel G. Fam, Shelly M. Dunne, John Iazzetta, and Thomas W. Paton

239

Evidence for Linkage of the HLA-B Locus in Behcet's Disease, Obtained using the Transmission Disequilibrium Test

Ahmet Gul, Ali H. Hajeer, Jane Worthington, Jennifer H. Barrett, William E. R. Ollier, and Alan J. Silman

240

Beneficial Effect of Etanercept on Rheumatoid Lymphedema

Barbara E. Ostrov

242

Increase in the Heart Rate-Corrected QT Interval in Children of Anti-Ro-Positive Mothers, with a Further Increase in Those with Siblings with Congenital Heart Block: Comment on the Article by Cimaz et al

Patrick A. Gordon, Munther A. Khamashta, Graham R. V. Hughes, and Eric Rosenthal

243

Rolando Cimaz, Antonio Brucato, Marco Stramba-Badiale, Luca Catelli, and Pier Luigi Meroni

243

Shrinking Lung Syndrome in Patients without Systemic Lupus Erythematosus: Comment on the Concise Communication by Tavoni et al

Shahbaz Ahmed, Ariane Herrick, and B. Ronan O'Driscoll

245

A. Tavoni and S. Bombardieri

245

Similar Effects of Pulse Corticosteroid and Tumor Necrosis Factor [alpha] Blockade in Rheumatoid Arthritis: Comment on the Article by Taylor et al

Malcolm D. Smith, Michael J. Ahern, Peter J. Roberts-Thomson, and Peter P. Youssef

245

Peter C. Taylor, Ewa Paleolog, and Ravinder N. Maini

169

Lupus Erythematosus Cells in the Kidney and Synovial Fluid

B. M. Atiquzzaman, Daniel D. Ricciardi, Yusuf Yazici, and Allan Gibofsky

241

Cervical Spinal Cord Compression

Kari Laiho, Markku Kauppi, and Irma Soini

43A

 ACR Announcements

Cover image: The figure on the cover (from De Bari et al, page 92) shows immunofluorescence staining for type II collagen in transforming growth factor [beta]1-treated micromasses derived from human periosteum-derived cells (PDC). The demonstration of type II collagen in these micromasses is evidence that PDC have chondrogenic potential and can develop into cartilage. The chondrogenic potential of PDC may provide the basis for tissue engineering to regenerate or resurface cartilage.