2381

Tumor Necrosis Factor [alpha] Blockers and the Induction of Anti-DNA Autoantibodies

David S. Pisetsky

2383

Assessment of Antibodies to Double-Stranded DNA Induced in Rheumatoid Arthritis Patients Following Treatment with Infliximab, A Monoclonal Antibody to Tumor Necrosis Factor [alpha]: Findings in Open-Label and Randomized Placebo-Controlled Trials

P. J. Charles, R. J. T. Smeenk, J. De Jong, M. Feldmann, and R. N. Maini

2391

Systemic Anti-Tumor Necrosis Factor [alpha] Therapy in Rheumatoid Arthritis Down-Regulates Synovial Tumor Necrosis Factor [alpha] Synthesis

Ann-Kristin Ulfgren, Ulf Andersson, Marianne Engstrom, Lars Klareskog, Ravinder N. Maini, and Peter C. Taylor

2397

Combination Drug Therapy Retards the Development of Rheumatoid Atlantoaxial Subluxations

Marko H. Neva, Markku J. Kauppi, Hannu Kautiainen, Reijo Luukkainen, Pekka Hannonen, Marjatta Leirisalo-Repo, Martti Nissila, and Timo Mottonen, for the FIN-RACo Trial Group

2402

Early Predictors of Poor Functional Outcome in Systemic-Onset Juvenile Rheumatoid Arthritis: A Multicenter Cohort Study

Lynn R. Spiegel, Rayfel Schneider, Bianca A. Lang, Nina Birdi, Earl D. Silverman, Ronald M. Laxer, Derek Stephens, and Brian M. Feldman

2410

The Genetic Contribution to Radiographic Hip Osteoarthritis in Women: Results of a Classic Twin Study

Alexander J. MacGregor, Leto Antoniades, Matthew Matson, Toby Andrew, and Tim D. Spector

2417

Association of Genotypes Affecting the Expression of Interleukin-1[beta] or Interleukin-1 Receptor Antagonist with Osteoarthritis

Verena Moos, Martin Rudwaleit, Volker Herzog, Kai Hohlig, Joachim Sieper, and Brigitte Muller

2423

The Role of Subchondral Insufficiency Fracture in Rapid Destruction of the Hip Joint: A Preliminary Report

Takuaki Yamamoto and Peter G. Bullough

2428

Detection of Cerebral Involvement in Patients with Active Neuropsychiatric Systemic Lupus Erythematosus by the Use of Volumetric Magnetization Transfer Imaging

G. P. Th. Bosma, M. J. Rood, T. W. J. Huizinga, B. A. de Jong, E. L. E. M. Bollen, and M. A. van Buchem

2437

Severe Organ Involvement in Systemic Sclerosis with Diffuse Scleroderma

Virginia D. Steen and Thomas A. Medsger, Jr.

2445

Skin Thickness Score as a Predictor and Correlate of Outcome in Systemic Sclerosis: High-Dose Versus Low-Dose Penicillamine Trial

Philip J. Clements, Eric L. Hurwitz, Weng Kee Wong, James R. Seibold, Maureen Mayes, Barbara White, Fredrick Wigley, Michael Weisman, Walter Barr, Larry Moreland, Thomas A. Medsger, Jr., Virginia D. Steen, Richard W. Martin, David Collier, Arthur Weinstein, Edward Lally, John Varga, Steven R. Weiner, Brian Andrews, Micha Abeles, and Daniel E. Furst

2455

Increased Interleukin-17 Production in Patients with Systemic Sclerosis

Kazuhiro Kurasawa, Koichi Hirose, Hideki Sano, Hideharu Endo, Hiroshi Shinkai, Yasushi Nawata, Katsuhiko Takabayashi, and Itsuo Iwamoto

2464

Autoantibodies to Fibrillin 1 in Systemic Sclerosis: Ethnic Differences in Antigen Recognition and Lack of Correlation with Specific Clinical Features or HLA Alleles

Filemon K. Tan, Frank C. Arnett, John D. Reveille, Chul Ahn, Stephan Antohi, Takeshi Sasaki, Kioshi Nishioka, and Constantin A. Bona

2472

Vascular Endothelial Growth Factor Production in Polymyalgia Rheumatica

Riccardo Meliconi, Lia Pulsatelli, Paolo Dolzani, Luigi Boiardi, Pierluigi Macchioni, Carlo Salvarani, Tania Silvestri, Luigi Frizziero, and Andrea Facchini

2481

Epidemiology of Wegener's Granulomatosis in Northern Norway

Wenche Koldingsnes and Hans Nossent

2488

Evaluation of Antineutrophil Cytoplasmic Antibody Seroconversion Induced by Minocycline, Sulfasalazine, or Pencillamine

Hyon K. Choi, Marjan C. Slot, Guoli Pan, Charyl A. Weissbach, John L. Niles, and Peter A. Merkel

2493

The Role of Catastrophizing in the Pain and Depression of Women with Fibromyalgia Syndrome

Afton L. Hassett, John D. Cone, Sondra J. Patella, and Leonard H. Sigal

2501

Activation, Differential Localization, and Regulation of the Stress-Activated Protein Kinases, Extracellular Signal-Regulated Kinase, c-Jun N-Terminal Kinase, and p38 Mitogen-Activated Protein Kinase, in Synovial Tissue and Cells in Rheumatoid Arthritis

Georg Schett, Makiyeh Tohidast-Akrad, Josef S. Smolen, Beatrice Jahn Schmid, Carl-Walter Steiner, Peter Bitzan, Peter Zenz, Kurt Redlich, Qingbo Xu, and Gunter Steiner

2513

Intercellular Adhesion Molecule 1 Underlies the Functional Heterogeneity of Synovial Cells in Patients with Rheumatoid Arthritis: Involvement of Cell Cycle Machinery

Yoshiya Tanaka, Masashi Nomi, Koichi Fujii, Stefan Hubscher, Akihiko Maruo, Shigeru Matsumoto, Yuichiro Awazu, Kazuyoshi Saito, Sumiya Eto, and Yasuhiro Minami

2523

Expression of Osteoclast Differentiation Factor in Rheumatoid Arthritis

Yukio Shigeyama, Thomas Pap, Peter Kunzler, Beat R. Simmen, Renate E. Gay, and Steffen Gay

2531

Modulation of Fibroblast-Mediated Cartilage Degradation by Articular Chondrocytes in Rheumatoid Arthritis

Thomas Pap, Willemijn H. van der Laan, Karlfried R. Aupperle, Renate E. Gay, Jay H. Verheijen, Gary S. Firestein, Steffen Gay, and Michel Neidhart

2537

Annexin I Surface Binding Sites and Their Regulation on Human Fibroblast-Like Synoviocytes

Annaleise V. Sampey, Paul Hutchinson, and Eric F. Morand

2543

Sex and Site Differences in Cartilage Development: A Possible Explanation for Variations in Knee Osteoarthritis in Later Life

Graeme Jones, Michael Glisson, Kristen Hynes, and Flavia Cicuttini

2550

Endothelial Cell Apoptosis in Systemic Sclerosis is Induced by Antibody-Dependent Cell-Mediated Cytotoxicity Via CD95

Roswitha Sgonc, Matthias S. Gruschwitz, Guenther Boeck, Norbert Sepp, Johann Gruber, and Georg Wick

2563

Adenovirus Mediated Gene Transfer of Insulin-Like Growth Factor 1 Stimulates Proteoglycan Synthesis in Rabbit Joints

Zhibao Mi, Steven C. Ghivizzani, Eric R. Lechman, Daniel Jaffurs, Joseph C. Glorioso, Christopher H. Evans, and Paul D. Robbins

2571

The Role of CD40 Ligand and Tumor Necrosis Factor [alpha] Signaling in the Transgenic K/BxN Mouse Model of Rheumatoid Arthritis

Diego Kyburz, Dennis A. Carson, and Maripat Corr

2578

Unmethylated Oligo-DNA Containing CpG Motifs Aggravates Collagen-Induced Arthritis in Mice

Masayuki Miyata, Hiroko Kobayashi, Tomomi Sasajima, Yukio Sato, and Reiji Kasukawa

2583

Oral Antibiotics as a Novel Therapy for Arthritis: Evidence for a Beneficial Effect of Intestinal Escherichia coli

Edward E. S. Nieuwenhuis, Maarten R. Visser, Annemieke Kavelaars, Pieter M. Cobelens, Andre Fleer, Wil Harmsen, Jan Verhoef, Louis M. A. Akkermans, and Cobi J. Heijnen

2590

Therapeutic Efficacy of a Novel Membrane-Targeted Complement Regulator in Antigen-Induced Arthritis in the Rat

Stuart M. Linton, Anwen S. Williams, Ian Dodd, Richard Smith, Bryan D. Williams, and B. Paul Morgan

2598

Increased Numbers of Microchimeric Cells of Fetal Origin are Associated with Dermal Fibrosis in Mice Following Injection of Vinyl Chloride

Paul J. Christner, Carol M. Artlett, Raymond F. Conway, and Sergio A. Jimenez

2606

Development of Diabetes Mellitus During Etanercept Therapy in a Child with Systemic-Onset Juvenile Rheumatoid Arthritis

Bradley J. Bloom

2608

Multiple Myeloma Presenting as Shoulder Pain

George A. W. Bruyn and Philippe R. Tondu

2609

Serious Liver Disease in a Patient Receiving Methotrexate and Leflunomide

Michael E. Weinblatt, Jonathan A. Dixon, and Kenneth R. Falchuk

2611

Twins Concordant for Juvenile Rheumatoid Arthritis

Sampath Prahalad, Mary H. Ryan, Edith S. Shear, Susan D. Thompson, David N. Glass, and Edward H. Giannini

2612

Possible Association of ``Shrinking Lung'' and Anti-Ro/SSA Antibody

Masaru Ishii, Hiroshi Uda, Tamotsu Yamagami, and Yoshinori Katada

2614

Lack of Epstein-Barr Virus Infection of Synovial Membranes in Patients with Rheumatoid Arthritis: Comment on the Article by Niedobitek et al

Pierre Brousset

2614

Serum Matrix Metalloproteinase 3 as a Predictor of Joint Destruction in Rheumatoid Arthritis: Comment on the Article by Yamanaka et al

Derek L. Mattey, Peter T. Dawes, and Nap T. Cheung

2615

Reply

Hisashi Yamanaka and Naoyuki Kamatani

2615

Folic Acid Supplementation and Methotrexate Efficacy: Comment on the Articles by Schiff, Emery et al, and Others

Vibeke Strand, Sarah L. Morgan, Joseph E. Baggott, and Graciela S. Alarcon

2617

Antiperinuclear Factor and Antikeratin Antibody in the Diagnosis of Rheumatoid Arthritis: Comment on the Article by Kim and Weisman

M. Nergis Yanmaz Alnigenis and Peter Barland

2617

IgG Glycosylation Status as a Clinical Predictor of Rheumatoid Arthritis: Comment on the Article by Kim and Weisman

David A. Isenberg and Adam Young

2618

Systemic Sclerosis Sine Scleroderma: Comment on the Article by Poormoghim et al

Gleb Slobodin, Itzhak Rosner, Michael Rozenbaum, Jochanan E. Naschitz, Elimelech Zuckerman, Daniel Yeshurun, and Bruce Rappaport

2618

Error in statement on JIA gender ratio in article by Wise et al (Arthritis Rheum, September 2000)

29A

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