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Official Journal of the American College of Rheumatology
Special Articles
Review: Biologic Agents for Treating Rheumatoid Arthritis: Concepts and Progress
Larry W. Moreland, Louis W. Heck, Jr., and William J. Koopman 397
Editorial: Standards of Care: The Value and Importance of Standardization
Josef S. Smolen, Gunter Steiner, and Eng M. Tan 410
Clinical Science
Reference Sera for Antinuclear Antibodies. II. Further Definition of Antibody Specificities in International Antinuclear Antibody Reference Sera by Immunofluorescence and Western Blotting
Josef S. Smolen, Brian Butcher, Marvin J. Fritzler, Thomas Gordon, John Hardin, Joachim R. Kalden, Robert Lahita, Ravinder N. Maini, Westley Reeves, Morris Reichlin, Naomi Rothfield, Yoshinari Takasaki, Walther J. van Venrooij, and Eng M. Tan 413
Meaningful Improvement Criteria Sets in Rheumatoid Arthritis Clinical Trial
Stanely R. Pillemer, Sarah E. Fowler, Barbara C. Tilley, Graciela S. Alarcon, Stephen P. Heyse, David E. Trentham, Rosemarie Nauner, Daniel O. Clegg, James C. C. Leisen, Sheldon M. Cooper, Howard Duncan, Marilyn Tuttleman, for the MIRA Trial Group 419
Total Lymphoid Irradiation in Rheumatoid Arthritis: A Ten-Year Followup
Rene Westhovens, Jo Verwilghen, and Jan Dequeker 426
Juvenile Rheumatoid Arthritis-Like Polyarthritis in Chromosome 22q11.2 Deletion Syndrome (DiGeorge Anomalad/Velocardiofacial Syndrome/Conotruncal Anomaly Face Syndrome)
Kathleen E. Sullivan, Donna M. McDonald-McGinn, Deborah A. Driscoll, Chester M. Zmijewski, Abdou S. Ellabban, Lori Reed, Beverly S. Emanuel, Elaine H. Zackai, Balu H. Athreya, and Gregory Keenan 430
Breast Implants in Patients with Differentiated and Undifferentiated Connective Tissue Disease
H. James Williams, Michael H. Weisman, and Charles C. Berry 437
Incidence of Systemic Sclerosis in Allegheny County, Pennsylvania: A Twenty-Year Study of Hospital-Diagnosed Cases, 1963-1982
Virginia D. Steen, Chester V. Oddis, Claudia G. Conte, Janine Janoski, Gayle Ziegler Casterline, and Thomas A. Medsger, Jr. 441
Increased Rates of Fibromyalgia Following Cervical Spine Injury: A Controlled Study of 161 Cases of Traumatic Injury
Dan Buskila, Lily Neumann, Genady Vaisberg, Daphna Alkalay, and Frederick Wolfe 446
Perceived Physical and Emotional Trauma as Precipitating Events in Fibromyalgia: Associations with Health Care Seeking and Disability Status But Not Pain Severity
Leslie A. Aaron, Laurence A. Bradley, Graciela S. Alarcon, Mireya Triana-Alexander, Ronald W. Alexander, Michelle Y. Martin, and Kristin R. Alberts 453
Relationship Between Biochemical Markers of Bone Turnover and Bone Scintigraphic Indices in Assessment of Paget's Disease Activity
Luisa Alvarez, Pilar Peris, Francisca Pons, Nuria Guanabens, Ramon Herranz, Ana Monegal, Jose L. Bedini, Ramon Deulofeu, M. Jesus Martinez de Osaba, Jose Munoz-Gomez, and Antonio M. Ballesta 461
Basic Science
Human Synovial Mast Cells. II. Heterogeneity of the Pharmacologic Effects of Antiinflammatory and Immunosupressive Drugs
Amato de Paulis, anna Ciccarelli, Isabella Marino, Gennaro de Crescenzo, Domenico Marino, and Gianni Marone 469
Mast cell Responses in Rheumatoid Synovium: Association of the MCTC Subset with Matrix Turnover and Clinical Progression
Ian Gotis-Graham and H. Patrick McNeil 479
Rheumatoid Arthritis Synovial Fibroblast and U937 Macrophage/Monocyte Cell Line Interaction in Cartilage Degradation
Boyd B. Scott, Lisa M. Weisbrot, Janice D. Greenwood, Earl R. Bogoch, Christopher J. Paige, and Edward C. Keystone 490
Macrophage Cathespin L, A Factor in the Erosion of Subchondral Bone in Rheumatoid Arthritis
Yasuo Iwata, John S. Mort, Hiroomi Tateishi, and eunice R. Lee 499
Clonal Expansion of Mycobacterial Heat-Shock Protein-Reactive T Lymphocytes in the Synovial Fluid and Blood of Rheumatoid Arthritis Patients
Linda Celis, Caroline Vandevyver, Piet Geusens, Jan Dequeker, Jef Raus, and Jingwu Zhang 510
CR1, CD35 in Synovial Fluid from Patients with Inflammatory Joint Diseases
Salima Sadallah, Estelle Lach, Hans U. Lutz, Sibylle Schwarz, Pierre-Andre Guerne, and Jurg A. Schifferli 520
The Effects of Functional Supression of a Mambrane-Bound Complement Regulatory Protein, CD59, in the Synovial Tissue in Rats
Masashi Mizuno, Kazuhiro Nishikawa, Rhian M. Goodfellow, Sara J. Piddlesden, B. Paul Morgan, and Seiichi Matsuo 527
Adjuvant Arthritis as a Model of Inflammatory Cachexia
Ronenn Roubenoff, Lisa M. Freeman, Donald E. Smith, Leslie W. Abad, Charles A. Dinarello, and Joseph J. Kehayias 534
Up-Regulation of Class II Major Histocompatibility Complex and Intercellular Adhesion Molecule 1 Expression on Scleroderma Fibroblasts and Endothelial Cells by Interferon-γ and Tumor Necrosis Factor α in the Early Disease Stage
Matthias S. Gruschwitz and Gisela Vieth 540
Endothelial Cells as Target for Antiphospholipid Antibodies: Human Polyclonal and Monoclonal Anti-β2-Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2-Glycoprotein I and Induce Endothelial Activation
N. Del papa, Guidali, A. Sala, C. Buccellati, M. A. Khamashta, K. Ichikawa, t. Koike, G. Balestrieri, A. Tincani, G. R. V. Hughes, and P. L. Meroni 551
Supression of Cartilage Matrix Gene Expression in Upper Zone Chondrocytes of Osteoarthritic Cartilage
T. Aigner, S. I. Vornehm G. Zeiler, J. Dudhia, K. von der Mark, and M. T. Bayliss 562
Erratum 569
Case Reports
Surgical Management of Calcinosis Cutis Universalis in Systemic Lupus Erythematosua
Marleen A. M. Cousins, Daniel B. Jones, Michael P. Whyte, and William W. Monafo 570
Chronic Meningitis with Cranial Neuropathies in Wegener's Granulomatosis: Case Report and Review of the Literature
H. A. Jinnah, Anne Dixon, Daniel J. Brat, and David B. Hellmann 573
Tenosynovial Nodulosis in a Patient Infected with Human T Cell Lymphotropic Virus I
Tomoko Hasunuma, Tadanobu, Morimoto, Tran Thi Minh Hoa, Ulf Muller-Ladner, Hiroyuki Aono, Ryokei Ogawa, Steffen Gay, and Kusuki Nishioka 578
Radiologic Vignette
Hip Pain in an Adolescent
Bert L. Pear and Ray F. Kilcoyne 583
Concise Communications
Acute Intermittent Porphyria Presenting as Acute Muscle Pain, Fever, and Weakness
Phillip L. Cohen, Nortin M. Hadler, and Robert Starkenburg 586
Lambda Light Chain Deposition Disease Presenting as Sicca Syndrome
Mohamed A. Hamidou, Christelle Gires, Anne Moreau, Stephane Martin, Francoise Buzelin, and Jean-Yves Grolleau 587
Letters
Scurvy is not a Rare Cause of Pseudovasculitis: Comment on the Concise Communication by Mehta et al
Paul M. Wallach, Harold M. Adelman, Mitchel J. Seleznick, Keith S. Kanik, Carmen G. Espinoza, and Luis R. Espinoza 589
Reply
Alan J. Bridges 589
Role of Oncostatin M in the Regulation of Cartilage Macromolecule Metabolism: Comment on the Article by Nemoto et al
Graeme Carroll, Michael Bell, and Wang Hui 589
Reply
Osamu Nemoto
Serum Biologic Markers as Predictors of Disease Progression in Osteoarthritis of the Knee
Claire Georges, Helene Vigneron, Xavier Ayral, Veronique Listrat, Philippe Ravaud, Maxime Dougados, Mohammed Sharif, Paul Dieppe, and Tore Saxne 590
Reactive or Septic Arthritis? Comment on the Article by Li et al
Thierry Schaeverbeke, Cecile Bebear, Bernard Bannwarth, Christiane Bebear, and Joel Dehais 592
Reply
H. Ralph Schumacher and William V. Williams 593
Smoking and Rheumatoid Arthritis—Observations from a Multicase Family Study: Comment on the Article by Silman et al
J. E. McDonagh and D. J. Walker 594




