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Official Journal of the American College of Rheumatology
EDITORIALS
Need for Circumspection in Prescribing Tumor Necrosis Factor Inhibitors and Other Biologic Response
Eric L. Matteson 1
Alternative Medicine and The Arthritis Foundation
Donald M. Marcus 5
ORIGINAL ARTICLE
Ankylosing Spondylitis
Assessment of Fatigue in Patients With Ankylosing Spondylitis: A Psychometric Analysis
Astrid van Tubergen, Jolanda Coenen, Robert Landewe, Anneke Spoorenberg, Astrid Chorus, Annelies Boonen, Sjef van der Linden, and Desiree van der Heijde 8
Etanercept Therapy
Experience With Etanercept in an Academic Medical Center: Are Infection Rates Increased?
Kristine Phillips, M. Elaine Husni, Elizabeth W. Karlson, and Jonathan S. Coblyn 17
Fibromyalgia
The Effects of Progressive Strength Training and Aerobic Exercise on Muscle Strength
Daniel S. Rooks, Caroline B. Silverman, and Fred G. Kantrowitz 22
Giant-Cell Arteritis
A Strong Initial Systemic Inflammatory Response is Associated With Higher Corticosteroid Requirements and Longer Duration of Therapy in Patients With Giant-Cell Arteritis
Jose Hernandez-Rodriguez, Ana Garcia-Martinez, Jordi Casademont, Xavier Filella, Maria-Jose Esteban, Alfonso Lopez-Soto, Joaquim Fernandez-Sola, Alvaro Urbano-Marquez, Josep M. Grau, and Maria C. Cid 29
Nonsteroidal Antiinflammatory Drug Therapy
Role of Initial NSAID Choice and Patient Risk Factors in the Prevention of NSAID Gastropathy: A Decision Analysis
A. Mark Fendrick, Rajesh R. Bandekar, Michael E. Chernew, and James M. Scheiman 36
Osteoarthritis
Joint Protection and Home Hand Exercises Improve Hand Function in Patients With Hand Osteoarthritis: A Randomized Controlled Trial
Tanja Alexandra Stamm, Klaus Peter Machold, Josef Sebastian Smolen, Sabine Fischer, Kurt Redlich, Winfried Graninger, Wolfgang Ebner, and Ludwig Erlacher 44
Structural Effect of Avocado/Soybean Unsaponifiables on Joint Space Loss in Osteoarthritis of the Hip
Michel Lequesne, Emmanuel Maheu, Christian Cadet, and Renee-Liliane Dreiser 50
Rheumatoid Arthritis
Step-Down Approach Using Either Cyclosporin A or Methotrexate as Maintenance Therapy in Early Rheumatoid Arthritis
Antonio Marchesoni, Norma Battafarano, Marco Arreghini, Raffaele Pellerito, Maria Cagnoli, Porziana Prudente, Alfonso Cerase, Francesco Priolo, and Sergio Tosi 59
The Number of Deformed Joints as a Surrogate Measure of Damage in Rheumatoid Arthritis
Carlos H. Orces, Inmaculada del Rincon, Michael P. Abel, and Agustin Escalante 67
Systemic Sclerosis
Design and Quality Considerations for Randomized Controlled Trials in Systemic Sclerosis
Maria Kyriakidi and John P. A. Ioannidis 73
CONTRIBUTIONS FROM THE FIELD
The Effect of Graded Resistance Exercise on Fibromyalgia Symptoms and Muscle Bioenergetics: A Pilot Study
Stanley E. Geel and Robert A. Robergs 82
SPECIAL ARTICLES
Combination Cytokine Therapy: The Next Generation of Rheumatoid Arthritis Therapy?
Arthur Kavanaugh 87
American College of Rheumatology Basic Research Conference: Genetics and Genomics in Rheumatic Disease
John B. Harley, Jeffrey Trent, and Daniel L. Kastner, for the Conference Participants 93
REVIEW ARTICLE
Splinting the Juvenile Arthritic Wrist: A Clinical Observation
Paul J. M. Helders, Janjaap van der Net, and Marianne K. Nieuwenhuis 99
TRAINEE ROUNDS
Cryptococcal Arthritis, Tendinitis, Tenosynovitis, and Carpal Tunnel Syndrome: Report of a Case and Review of the Literature
Kimberly M. Bruno, Ladan Farhoomand, Bonita S. Libman, Charles N. Pappas, and Frank J. Landry 104
LETTERS
Are You Better? Comment on the Article by Beaton et al
Jeremy G. Jones 109
Vesalius, Also a Rheumatologist?
Thierry Appelboom and Joelle Margaux 109
ANNOUNCEMENTS 12A
Cover Illustration: Polyarteritis nodosa was the first noninfectious vasculitis to be described and studied in detail. Research on this group of vasculitides has been the cornerstone for understanding the pathophysiology of other forms of idiopathic vasculitis. Historically, most forms of vasculitis described subsequently have been characterized and classified on the basis of features either similar to or distinct from polyarteritis.
In 1852, Karl (later Freiherr von) Rokitansky, the great Viennese pathologist, described the first case of polyarteritis nodosa (1). He had noted aneurysmal lesions with nodes in numerous arteries observed at autopsy in a 23-year-old shoemaker's journeyman, Wenzel Plohner. The drawing of the mesentery shows multiple macroscopically apparent arterial nodules with aneurysms at the branching point of smaller arteries. Rokitansky did not microscopically examine the specimen, and did not recognize the inflammatory nature of the vascular lesion. He viewed the aneurysms as located eccentrically on the sides of the involved artery, connected to the lumen of the artery by a small opening, or ostium. In describing the aneurysms, he states "Larger or smaller, often barely perceptible, needle-point sized openings in the vessel lumen led into these, which had the appearance of a delicate vessel ostium" (2).
The classic description of polyarteritis nodosa by the internist Adolf Kussmaul, and pathologist Rudolf Maier in Freiburg, Germany, is based on their report of a 27-year-old journeyman tailor by the name of Carl Seufarth (3). At autopsy, nodules along medium-sized arteries were visible to the naked eye. The drawing of the patient's heart demonstrates numerous nodular thickenings of the coronary arteries. Histologic examination revealed "abundant nucleosis" with "alternating areas of constrictions and dilatations" (2).
1. Rokitansky K. eber einige der wichtigsten Erkrankungen der Arterien. Denkschriften der kaiserlichen Akademie der Wissenschaften (mathematisch-naturwissenschaftliche Classe). Vienne, kaiserlich-koniglich Hof-und Staatsdruckerei. 1852;4:1-72.
2. Matteson EL. A history of idiopathic vasculitis. Rochester (MN): Mayo Clinic Press; 1999.
3. Jussmaul A, Maier R, Ueber eine bisher nicht beschriebene eigenthumliche Arterienerkrankung (Periarteritis nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskellahmung einhergeht. Deutsche Arch Klin Med 1866;1:484-516.
(Submitted by Eric L. Matteson, MD, MPH, Mayo Clinic, Rochester, MN)
