When an older person complains of a new, persisting headache, especially if accompanied by flu-like symptoms or weight loss, it can be due to a condition called giant cell arteritis. This disease of blood vessels can occur together with polymyalgia
rheumatica.
Fast Facts
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Giant cell arteritis affects older adults, usually those over the
age of 60.
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If GCA impairs blood flow to the eye, loss of vision can occur.
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To prevent complications, GCA should be diagnosed and treated as
soon as possible.
What giant cell arteritis is
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| A biopsy shows diffuse inflammation of the temporal artery |
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Giant cell arteritis (GCA) is a type of vasculitis or arteritis, a group
of diseases whose typical feature is inflammation of blood vessels. In
the case of GCA, the vessels most commonly involved are the arteries of
the scalp and head, especially the arteries over the temples, which is
why another term for GCA is “temporal arteritis.”
GCA can overlap with another disease, polymyalgia
rheumatica (PMR). At some point, 5 to 15% of patients with PMR will be diagnosed with GCA. Looked at anotherway, about 50% of patients with GCA have symptoms of PMR. The symptoms of the two conditions can occur at the same time or separately.
The most common symptom of GCA is a new headache, usually in the area of the temples, although headache due to GCA can occur anywhere, including the front, top and back of the skull. Almost as common are more generalized symptoms, such as unusual fatigue, loss of appetite, weight loss, a flu-like feeling or fevers. Occasionally the only indication of GCA is a recurring, prolonged fever. Less common symptoms involve pain in the jaw when chewing or facial, tongue or throat pain.
If GCA spreads to the blood supply of the eye, vision can be affected. Visual symptoms include temporary blurring, double vision or actual blindness. Loss of vision in GCA can occur suddenly and usually cannot be reversed. What is important, however, is that this complication can be prevented with appropriate treatment. In fact, if vision is intact at the time treatment for GCA is started, the risk of visual loss is 1 in 100 or less. It is essential that patients who have PMR, either active or inactive, immediately report any symptoms of new headache, visual symptoms or jaw pain to their physicians.
What causes giant cell arteritis
Like PMR, the cause of GCA is unknown.
Who gets giant cell arteritis
GCA affects the same patients as PMR: only older adults, females more than
males, and whites more than nonwhites.
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| This picture shows the swelling and
thickening of the small artery under the skin referred to as
the
temporal artery. |
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How giant cell arteritis is diagnosed
Unfortunately, there is no blood test or noninvasive way to confirm the diagnosis of GCA. The erythrocyte sedimentation rate, or “sed rate,” a blood test that provides an indirect measure of inflammation, is usually significantly elevated in people with GCA. Because other diseases can cause high sedimentation rates, however, this finding cannot be relied on for proof of the diagnosis of GCA. Accordingly, it is common to recommend a biopsy of a small piece of the temporal artery, which is then examined under the microscope for evidence of inflammation. The temporal artery biopsy is an outpatient procedure, done under local anesthesia, and leaves only a small scar that generally cannot be seen at the hairline in front of the ear.
How giant cell arteritis is treated
The treatment for GCA should begin as soon as possible because of the risk of loss of vision. If the diagnosis is strongly suspected, treatment can be started before the diagnosis has been confirmed by temporal artery biopsy. Unlike the treatment for PMR, which requires only low dose corticosteroids, high doses of corticosteroids are usually given for the treatment of GCA, typically 40-60 mg of prednisone (Deltasone, Orasone, etc.) per day. Headaches and other symptoms subside quickly, and the sedimentation rate declines to a normal range. The high dose of corticosteroids is kept up usually for 1 month and then slowly decreased. The speed at which the dose is lowered may have to be adjusted if there are recurring symptoms of GCA or significant rises in the sedimentation rate but, in most cases, the prednisone dose can be reduced to about 5-10 mg per day over several months, and discontinued entirely after 1-2 years. Subsequent recurrences of GCA are rare.
Living with giant cell arteritis
As would be expected, with higher doses of corticosteroids side-effects are more common, and must be monitored attentively by the physician. Baseline bone density testing should be done because corticosteroid treatment can cause bone loss. To protect against osteoporosis, supplements of calcium and vitamin D are recommended, often along with prescription medications, such as one of the bisphosphonates: risedronate (Actonel), alendronate (Fosamax), or ibandronate (Boniva). Some of the side effects from high dose corticosteroids—for example, jitteriness, sleeplessness, and weight gain—can be unpleasant, but are reversible, and subside as the dose is reduced. Muscle weakness, cataracts and skin bruising also can occur with corticosteroid use.
Points to Remember
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Appropriate excercise is key to maintaining good
health. |
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GCA, a disease of blood vessels, often occurs together with polymyalgia
rheumatica.
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New headache is a common symptom of GCA.
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Permanent loss of vision is the most concerning complication of untreated GCA.
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High doses of corticosteroids
are used for the treatment of GCA.
The rheumatologist's role in the treatment
of giant cell artertitis
Giant cell arteritis can be difficult to diagnose and requires prompt treatment to preserve vision. Rheumatologists are specialists in musculoskeletal disorders and, therefore, are more likely to make a proper diagnosis. They also can advise patients about the best treatment options available.
To find a rheumatologist
For more information about rheumatologists, click
here.
For a listing of rheumatologists in your area, click
here.
For more information
The American College of Rheumatology has compiled this list to give you
a starting point for your own additional research. The ACR does not endorse
or maintain these Web sites, and is not responsible for any information
or claims provided on them. It is always best to talk with your rheumatologist
for more information and before making any decisions about your care.
National Institute of Arthritis and Musculoskeletal and Skin Disease
(http://www.niams.nih.gov/
National Library of Medicine
http://www.nih.nih.gov/medlineplus
Updated June 2006
Written by William Docken, MD, and reviewed by the American College of Rheumatology
Patient Education Task Force.
