1990 Criteria for the Classification of Wegener's Granulomatosis (now known as Granulomatosis with Polyangiitis)
1) Nasal or oral inflammation
Development of painful or painless oral ulcers or purulent or bloody nasal discharge
2) Abnormal chest radiograph
Chest radiograph showing the presence of nodules, fixed infiltrates, or cavities
3) Urinary sediment
Microhematuria (>5 red blood cells per high power field) or red cell casts in urine sediment
4) Granulomatous inflammation on biopsy
Histologic changes showing
granulomatous inflammation within the wall of an artery or in the perivascular
or extravascular area (artery or arteriole)
* For
purposes of classification, a patient shall be said to have Wegener's granulomatosis
if at least 2 of these 4 criteria are present. The presence of any 2 or more
criteria yields a sensitivity of 88.2% and a specificity of 92.0%
Leavitt RY, Fauci AS,
Bloch DA, Michel BA, Hunder GG, Arend WP, et al. The American College of Rheumatology
1990 criteria for the classification of Wegener's granulomatosis. Arthritis
Rheum 1990;33:1101---7.