Glossary

Looking for rheumatic disease types, treatments, and associated rheumatology definitions? From abatacept to WOMAC, learn about common terms related to arthritis and rheumatic and musculoskeletal diseases. Looking for information about MACRA? See MACRA terms and definitions.


F

Familial Mediterranean fever

Inheritable disease caused by a gene mutation. Causes inflammation of the joints, lungs, or abdomen, as well as recurring fevers. Other symptoms include chest pain, muscle aches, rashes, swollen scrotum in men, constipation, and diarrhea. Typically occurs in ethnic groups with ancestry in the Mediterranean Sea region, such as Arabs, Armenians, Italians, Sephardi Jews, and Turks. Usually is diagnosed in childhood. Colchicine may help control inflammation.

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Fatigue

State, followed by a period of mental or reduced bodily activity, characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness, sleepiness, or irritability; may also supervene when, from any cause, energy expenditure outstrips restorative processes and may be confined to a single organ.

Fc receptor

Present on a variety of cells for the Fc fragment of immunoglobulins; recognizes immunoglobulins of the IgG and IgE class.

Fibromyalgia (FM)

Syndrome of chronic pain of musculoskeletal origin but uncertain cause. Is accompanied by fatigue, sleep, memory, and mood issues.

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Fracture Risk Assessment Tool (FRAX)

Developed by World Health Organization to evaluate fracture risk of patients. Based on individual patient models that integrate the risks associated with clinical risk factors as well as bone mineral density at the femoral neck. The algorithms give the 10-year probability of fracture. The output is a 10-year probability of hip fracture and the 10-year probability of a major osteoporotic fracture (clinical spine, forearm, hip, or shoulder fracture).

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Fractures

A break, especially the breaking of a bone or cartilage.